A5058840558- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Reconstructive Facial Surgery Techniques
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Surgical Simulation and Training
- Bone Tissue Engineering Materials
- Meningioma and schwannoma management
- Periodontal Regeneration and Treatments
- Facial Trauma and Fracture Management
- Sarcoma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Advanced Radiotherapy Techniques
- Bone fractures and treatments
- Tumors and Oncological Cases
- Cancer-related gene regulation
- Cleft Lip and Palate Research
University Health Network
2019-2025
Princess Margaret Cancer Centre
2019-2025
University of Toronto
2019-2025
University College London Hospitals NHS Foundation Trust
2023-2025
University College London
2021-2024
Royal London Hospital
2021-2024
Toronto General Hospital
2021-2024
University College Hospital
2021-2024
Western University
2017-2023
London Health Sciences Centre
2017-2023
Abstract Background Tobacco use is a major risk factor for developing head and neck squamous cell carcinoma (HNSCC). However, the prognostic associations with smoking cessation are limited. The authors assessed whether increased duration of abstinence were associated improved overall (OS) HNSCC‐specific survival. Methods Clinicodemographic data from patients HNSCC at Princess Margaret Cancer Center (2006–2019) prospectively collected. Multivariable Cox Fine Gray competing‐risk models used to...
Abstract Photodynamic therapy (PDT) is a tissue ablation technique able to selectively target tumor cells by activating the cytotoxicity of photosensitizer dyes with light. PDT nonsurgical and sparing, two advantages for treatments in anatomically complex disease sites such as oral cavity. We have previously developed PORPHYSOME (PS) nanoparticles assembled from chlorin photosensitizer–containing building blocks (∼94,000 photosensitizers per particle) capable potent PDT. In this study, we...
Abstract Skin photosensitization is a common challenge following intravenous administration of many photodynamic therapy (PDT) drugs, typically lasting days, weeks, or months in laboratory animals and patients. Symptoms photosensitivity manifest as erythema edema on skin exposed to sunlight bright artificial lighting. Recent efforts using nanocarriers increase photosensitizer accumulation tumors have also been shown reduce photosensitivity. We previously developed phototheranostic PORPHYSOME...
Abstract Background: Photodynamic therapy (PDT) is a non-surgical treatment using light to activate the cytotoxicity of photosensitizing drug in cancer cells. PORPHYSOMES (PS) are lipid-porphyrin nanoparticles with high tumor uptake and PDT efficacy as well low skin sensitivity. We have shown that activating PS ‘sub-therapeutic’ dose mouse models head neck (H&N) stimulates immunogenic cell death generates robust transferable anti-tumor immunity. Here, we demonstrate first evidence this...
Smoking has historically been recognized as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences between heavy smokers (>20 pack years) never among HNSCC patients within The Cancer Genome Atlas (TCGA). Single nucleotide variation copy number aberration were compared human papillomavirus-positive (HPV-positive) (n = 67) HPV-negative 431) TCGA cohorts with HNSCC, impact of these mutations on survival assessed. No...
Head-and-neck cancers (hncs) often present at an advanced stage, leading to poor outcomes. Late presentation might be attributable patient delays (reluctance seek treatment, for instance) or provider (misdiagnosis, prolonged wait time consultation, example). The objective of the study was examine length and cause such in a Canadian universal health care setting.Patients presenting first hnc multidisciplinary team (mdt) with biopsy-proven were recruited this study. Patients completed survey...
The scapular tip free flap (STFF) is becoming more popular for oromandibular reconstruction. This article reviewed the early and late outcomes in a larger series over 9 years.We conducted retrospective review of all consecutive patients who underwent reconstruction using STFF at London Health Sciences Centre. Demographic information, surgical data, complications were collected analyzed.From April 2008 to March 2017, 81 STFFs performed 80 patients. average bony measured 5.4 cm. Bone-only...
To report the first use of a novel projected augmented reality (AR) system in open sinonasal tumor resections preclinical models and to compare AR approach with an advanced intraoperative navigation (IN) system.Four were created. Five head neck surgeons participated study performing virtual osteotomies. Unguided, AR, IN, + IN simulations performed. Statistical comparisons between approaches obtained. Intratumoral cut rate was main outcome. The groups also compared terms percentage...
Plate extrusions after free tissue transfer for mandibular reconstruction can be problematic and generally require revision surgery. Our objective was to assess the predictors of plate extrusion compare outcomes between fibular flaps (FFF), lateral border scapular (LBSF), tip (STFF).Retrospective review consecutive patients who underwent osseous mandible (2008-2014) at Victoria Hospital, London, Ontario. Patient demographics treatment-related information were collected.We identified 134...
The genomic landscape of head and neck cancer has been reported through Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated genes are correlated with survival in an oral cohort.Patient demographic data along from final pathology was collected. Tumor DNA analyzed using a custom Illumina targeted sequencing panel. Five HPV types were tested by qPCR. Statistical analyses used identify associations between patient outcome mutational...
Objectives/Hypothesis The ideal strategy in the treatment of mucosal melanoma head and neck (MMHN) remains unclear. Our objective was to evaluate importance surgical margins, radiotherapy, systemic therapy MMHN. Study Design Retrospective Single Institutional Review. Methods review patients with MMHN treated at a tertiary care oncology center between 1999 2016. Results Seventy‐six were included, 60 whom curative intent. Negative or close margins compared positive associated higher 3‐year...
Adequate surgical margins are essential in oral cancer treatment, this is, however, difficult to appreciate during training. With advances training aids, we propose a silicone-based simulator improve proficiency for the ablation of cavity cancers. A tongue model constructed via 3D mold was compared porcine used as model. Participants varying experience were then asked resect tumors with clear margins, and thereafter fill out questionnaire evaluate face content validity models tool. Eleven...
Reconstruction of mandibular bone defects is a surgical challenge, and microvascular reconstruction the current gold standard. The field tissue bioengineering has been providing an increasing number alternative strategies for reconstruction.
Neck carcinoma of unknown primary (CUP) is a frequent scenario. Transoral robotic mucosectomies (TORM) pharynx have increased rate identification, but come with cost treatment delay.We reviewed patients who underwent CUP protocol from 2014 to 2020. Patients cervical nodes and failure localize source were classified as CUP. We determined identification postoperative complications.We included 65 TORM. Surgical approach consisted lingual and/or palatine tonsillectomies. The detection was 49.2%....
Although most thyroid nodules are benign, the potential for malignant neoplasms is associated with unnecessary workup in form of imaging, fine-needle aspiration, and diagnostic surgery. The American College Radiology Thyroid Imaging Reporting Data System (ACR TI-RADS) commonly used to assess neoplasm risk imaged by ultrasonography. However, standardized reporting ACR TI-RADS descriptors inconsistent.To increase documentation rate nodule characteristics 80% 18 months.This prospective...