A5003032418- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Ear and Head Tumors
- Tracheal and airway disorders
- Meningioma and schwannoma management
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Reconstructive Facial Surgery Techniques
- Voice and Speech Disorders
- Cleft Lip and Palate Research
- Trauma Management and Diagnosis
- Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Facial Nerve Paralysis Treatment and Research
- Craniofacial Disorders and Treatments
- Facial Trauma and Fracture Management
- Airway Management and Intubation Techniques
- Surgical Simulation and Training
- Nonmelanoma Skin Cancer Studies
- Bone fractures and treatments
- COVID-19 and healthcare impacts
- Otolaryngology and Infectious Diseases
Fondazione IRCCS Istituto Nazionale dei Tumori
2023-2025
University of Milan
2023-2024
Cancer Institute (WIA)
2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2020-2023
University of Brescia
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
GTx (United States)
2021
Brescia University
2020
State of Illinois
2020
University of Florence
2009-2018
Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. However, their prevalence in different patient populations still needs clarified.A cross-sectional study was performed from March 27 April 1, 2020, Northern Italy. Physicians administered survey-based questionnaire SARS-CoV-2-positive patients with the aim assessing symptoms, focusing on OD GD. Two groups were studied: group A,...
Objective To prospectively assess the rate and timing of recovery olfactory (OD) gustatory (GD) dysfunction in patients affected by COVID‐19. Study Design Cohort study. Setting Population‐based evaluation a COVID‐19 high‐prevalence region. Subjects Methods We analyzed clinical course OD GD cohort home‐quarantined SARS‐CoV‐2–positive from Northern Italy. Physicians administered survey‐based questionnaire at recruitment (T0). During follow‐up, responded to online dedicated surveys modulated...
Survival rates of oral squamous cell carcinoma (OSCC) remained substantially unchanged over the last decades; thus, additional prognostic tools are strongly needed.Salivary miRNAs have emerged as excellent non-invasive cancer biomarker candidates, but their association with OSCC prognosis has not been investigated yet.In this study, we analyzed global salivary miRNA expression in patients and healthy controls, aim to define its diagnostic potential.Methods: Saliva was collected from newly...
Fully convoluted neural networks (FCNN) applied to video-analysis are of particular interest in the field head and neck oncology, given that endoscopic examination is a crucial step diagnosis, staging, follow-up patients affected by upper aero-digestive tract cancers. The aim this study was test FCNN-based methods for semantic segmentation squamous cell carcinoma (SCC) oral cavity (OC) oropharynx (OP).Two datasets were retrieved from institutional registry tertiary academic hospital...
The restart of routine in‐ and outpatient activity in the COVID‐19 postepidemic peak needs to be carefully planned light specific patterns viral diffusion. We evaluated SARS‐CoV‐2 serology entire personnel a COVID‐19‐free otolaryngology department highly affected area. aim was determine prevalence positivity among staff clarify impact different risk factors for infection. unit tested serology. Symptomatic members were with nasal/pharyngeal swabs. All answered survey focused on number...
La trasposizione di lembi liberi microvascolari rappresenta oggi la procedura maggiormente diffusa nelle ricostruzioni del distretto testacollo. Tuttavia, non tutti i pazienti sono candidati ideali per microvascolari, né difetti richiedono necessariamente ottenere buoni risultati funzionali. Lo scopo questo studio è quello valutare se ricostruzione testa-collo mediante peduncolati sia inferiore alle in termini complicanze, outcome funzionale e prognosi. In una coorte consecutivi che stati...
Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate⁻advanced laryngeal cancers (LC). T⁻N categories well-known prognosticators: herein we tested if "anterior" vs. "posterior" tumor location (as defined in respect to the paraglottic space divided according a plane passing through arytenoid vocal process, perpendicular ipsilateral thyroid lamina) may represent an additional prognostic factor. We analyzed retrospective cohort of...
Abstract Purpose To investigate the potential reconstruction of complex maxillofacial defects using computer-aided design 3D-printed polymeric scaffolds by defining production process, simulating surgical procedure, and explore feasibility reproducibility whole algorithm. Methods This a preclinical study to feasibility, efficacy algorithm proposed. It encompassed 3 phases: (1) scaffold (CAD 3D-printing in polylactic acid); (2) simulation on cadaver heads (navigation-guided osteotomies...
The main concern in the treatment of laryngeal carcinomas is tumor control with preservation functions. We believe that salvage supracricoid partial laryngectomy (SPL) should be carefully considered selected cases radiotherapy failure, because it can offer possibility achieving adequate functions.A series 31 patients who underwent an SPL as procedure after failure was reviewed.Locoregional rate 75%, 60% 5-year overall survival; no were lost to follow-up, and a death-from-disease 19.35%...
Abstract Background In current practice, surgeons frequently deal with elderly patients who have severe medical comorbidities. Methods We present our series of 18 consecutive general comorbidities that received infrahyoid flap reconstruction. The results were compared those 16 in good state receiving free radial forearm reconstruction during the same study period. also describe an original method for tongue base using flap. Results No total necrosis was experienced; successful separation...
Olfactory neuroblastoma (ONB) is a rare sinonasal neoplasm with peculiar behavior, for which limited prognostic factors are available. Herein, we investigate the transcriptional pathways altered in ONB and correlate them pathological features clinical outcomes. We analyze 32 patients treated curative intent at two independent institutions from 2001 to 2019 whom there available pathologic data. perform gene expression profiling on primary samples carry out functional enrichment analysis key...
The COVID-19 pandemic was an extraordinary challenge for the global healthcare system not only number of patients affected by pulmonary disease, but also incidence long-term sequalae. In this regard, laryngo-tracheal stenosis (LTS) represents one most common complications invasive ventilation.A case series who underwent tracheal resection and anastomosis (TRA) post-COVID-19 LTS collected from June 2020 to September 2021.Among 14 included, 50% had diabetes 64.3% were obese. During intensive...
Abstract Introduction In the management of sinonasal malignancies treatment‐induced morbidity and mortality is gaining relevance both for surgical approaches (endoscopic open resection) non‐surgical therapies. The aim this multicenter study to assess complications associated with endoscopic surgery treatments (neoadjuvant and/or adjuvant) malignant tumors. Methods All patients nasoethmoidal treated curative intent or endoscopic‐assisted at three referral centers uniform policies were...