A5057836069- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Head and Neck Surgical Oncology
- Surgical Simulation and Training
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Augmented Reality Applications
- Reconstructive Surgery and Microvascular Techniques
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- Anatomy and Medical Technology
- Head and Neck Cancer Studies
- Reconstructive Facial Surgery Techniques
- Tracheal and airway disorders
- Medical Imaging Techniques and Applications
- Facial Trauma and Fracture Management
- Photoacoustic and Ultrasonic Imaging
- Dental Radiography and Imaging
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Sinusitis and nasal conditions
- Medical Imaging and Analysis
- Optical Imaging and Spectroscopy Techniques
- Ear Surgery and Otitis Media
- Spinal Fractures and Fixation Techniques
Princess Margaret Cancer Centre
2013-2024
University Health Network
2015-2024
University of Toronto
2012-2023
Health Net
2011-2020
Toronto Public Health
2020
Ontario Institute for Cancer Research
2009-2016
Cancer Institute (WIA)
2011-2013
Vancouver General Hospital
2013
University of British Columbia
2013
Abstract Indocyanine green (ICG) is the only near‐infrared (NIR) dye approved for clinical use. Despite its versatility in photonic applications and potential photothermal therapy, photobleaching hinders application. Here we discovered a nanostructure of dimeric ICG (Nano‐dICG) generated by using to stabilize nanoemulsions, after which enabled complete dimerization on nanoemulsion shell, followed J‐aggregation ICG‐dimer, resulting narrow, red‐shifted (780 nm→894 nm) intense (≈2‐fold)...
The aim of this study was to demonstrate the role advanced fabrication technology across a broad spectrum head and neck surgical procedures, including applications in endoscopic sinus surgery, skull base maxillofacial reconstruction. initial case studies demonstrated three rapid prototyping are surgery: i) mono-material paranasal phantom for endoscopy training ii) multi-material simulator iii) 3D patient-specific mandible templates. Digital processing these phantoms is based on real patient...
Purpose: The accuracy and convergence behavior of a variant the Demons deformable registration algorithm were investigated for use in cone‐beam CT (CBCT)‐guided procedures head neck. Online guidance therapeutic such as image‐guided surgery or radiation therapy places trade‐offs on computational expense. This work describes criterion developed to balance these demands; multiscale implementation using this is quantified CBCT images Methods: Using an open‐source “symmetric” algorithm, based...
Head and neck cancer is the fifth most common type of worldwide remains challenging for effective treatment due to proximity critical anatomical structures in head region, which increases probability toxicity from surgery radiotherapy, therefore emphasizes importance maximizing targeted ablation.We have assessed effectiveness porphysome nanoparticles enhance fluorescence photoacoustic imaging tumors rabbit hamster models.In addition, we evaluated this agent localized photothermal ablative...
Purpose: A method of intensity‐based deformable registration CT and cone‐beam (CBCT) images is described, in which intensity correction occurs simultaneously within the iterative process. The preserves speed simplicity popular Demons algorithm while providing robustness accuracy presence large mismatch between CBCT voxel values (“intensity”). Methods: variant was developed an estimate relationship for specific materials image computed at each iteration based on set currently overlapping...
J-aggregates display nanoscale optical properties which enable their use in fluorescence and photoacoustic imaging applications.
Objectives/Hypothesis Image‐guided surgery (IGS) systems are frequently utilized during cranial base to aid in orientation and facilitate targeted surgery. We wished assess the performance of our recently developed localized intraoperative virtual endoscopy (LIVE)‐IGS prototype a preclinical setting prior deployment operating room. This system combines real‐time ablative instrument tracking, critical structure proximity alerts, three‐dimensional endoscopic views, cone‐beam computed...
Abstract Purpose: The low survival rate of head and neck cancer (HNC) patients is attributable to late disease diagnosis high recurrence rate. Current HNC staging has inadequate accuracy sensitivity for effective treatment management. multimodal porphyrin lipoprotein-mimicking nanoparticle (PLP), intrinsically capable positron emission tomography (PET), fluorescence imaging, photodynamic therapy (PDT), shows great potential enhance the potentially Experimental Design: Using a clinically...
Augmented reality (AR) surgical navigation systems, designed to increase accuracy and efficiency, have been shown negatively impact on attention. We wished assess the effect "head-up" AR displays attention, accuracy, while performing a task, compared with same information being presented submonitor (SM).Fifty experienced otolaryngology surgeons (n = 42) senior trainees 8) performed an endoscopic exercise predissected cadaveric model. Computed tomography-generated anatomic contours were fused...
Background: This Sawbones and cadaver study was performed to assess the accuracy reproducibility of pelvic bone cuts made with use a novel navigation system navigated osteotome oscillating saw. Methods: Using three-dimensional planning tool, we that were representative typical in tumor resections. The includes prototype mobile C-arm for intraoperative cone-beam computed tomography, real-time optical tracking (Polaris), visualization software. Three-dimensional virtual radiographs utilized...
Video-assisted thoracoscopic surgery (VATS) has become a standard approach for the treatment of lung cancer. However, its minimally invasive nature limits field view and reduces tactile feedback. These limitations make it vital that surgeons thoroughly familiarize themselves with patient's anatomy preoperatively. We have developed virtual reality (VR) surgical navigation system using head-mounted displays (HMD). The aim this study was to investigate potential utility VR simulation in both...
Intraoperative 3-dimensional (3D) imaging in head and neck surgery was developed using a prototype mobile C-arm for cone-beam CT (CBCT). This article summarizes its implementation prospective pilot feasibility study.The CBCT used 12 surgical oncology cases. Human-factors engineering methods expert feedback from surgeons, nurses, anesthetists were to evaluate the impact of intraoperative on environment clinical workflow. Image quality perceived utility evaluated.The successfully incorporated...
Intraoperative imaging technologies including computed tomography and fluorescence optical are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents can increase sensitivity visualization power of existing intraoperative techniques will further enhance their clinical benefit. We report here development, detection a dual-modality...
In cancer patients, circulating tumour-derived DNA (ctDNA) levels imperfectly reflect disease burden apparent on medical imaging. Further evaluation of ctDNA over time is needed to better understand the correlation with tumour growth and therapeutic response. We describe kinetics within an orthotopic, immunocompetent preclinical rabbit model local-regionally advanced head neck squamous cell carcinoma (HNSCC). Monitoring primary metastatic lymph node volume by computed tomography (CT), we...
Conclusions: Flat-panel cone-beam computed tomography (CBCT) is able to assess the trajectory of implanted cochlear implant (CI) array. This essential determine specific effects electrode design and surgical innovations on outcomes in implantation. CBCT a non-invasive approach yielding similar data histopathological analyses, with encouraging potential for use surgical, clinical research settings. Objectives: To examine fidelity imaging custom 3D visualization characterizing CI insertion...
The purpose of this study was to evaluate the efficacy preoperative versus intraoperative mandibular contouring using rapid prototyping technology.Ten patients requiring reconstruction had a plate contoured fabricated 3D model based on imaging. A traditional also contoured. Two surgeons blinded compared plates with respect conformance, surface-area contact, and best overall match. cost-benefit analysis then performed.The average time contour 867 ± 243 seconds 833 289 for plates, respectively...
Abstract Objectives/Hypothesis: Our group has developed an augmented image guidance system that incorporates intraoperative cone‐beam computed tomography (CBCT), virtual or displays, and registration. We assessed the potential benefits of endoscopy derived from this for use during skull base navigation. Specifically, we wished to evaluate target localization accuracy effect on task workload confidence. Study Design: Prospective, sequential, paired preclinical trial. Methods: A single cadaver...
Abstract Background Scapular tip osteomyogenous free flaps have been described for complex palate reconstruction. Minimal osteotomies are needed because of the similar shapes scapula and palate. We compared bony morphology scapular to determine suitability Methods analyzed facial chest CT images 10 patients, comparing 3 simulated resection specimens (total palate, subtotal hemipalate) with corresponding bone from same patient. Results Conformance distances between palates were small,...
Background We set out to determine the accuracy of 3D-navigated mandibular and maxillary osteotomies with ultimate aim integrate virtual cutting guides 3D-navigation into ablative reconstructive head neck surgery. Methods Four surgeons (two attending, two clinical fellows) completed 224 unnavigated on anatomical models according preoperative 3D plans. The osteotomized bones were scanned analyzed. Results Median distance from plan was 2.1 mm (IQR 2.6 mm, ≥3 in 33%) 1.2 1.1 6%) (P<0.0001);...
An integrated augmented reality (AR) surgical navigation system that potentially improves intra-operative visualization of concealed anatomical structures. Integration real-time tracking technology with a laser pico-projector allows the surface to be by projecting virtual images lesions and critical structures created multimodality imaging. We aim quantitatively qualitatively evaluate performance prototype interactive AR through series pre-clinical studies. Four animal studies using...
A great promise for tissue engineering is represented by scaffolds that host stem cells during proliferation and differentiation simultaneously replace damaged while maintaining the main vital functions. In this paper, a novel process was adopted to develop composite with core-shell structure bone regeneration, in which core has function of temporary mechanical support, shell enhances biocompatibility provides bioactive properties. An interconnected porous safely obtained, avoiding solvents...