A5042893112- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Reconstructive Surgery and Microvascular Techniques
- Cerebral Venous Sinus Thrombosis
- Liver Disease Diagnosis and Treatment
- Ear and Head Tumors
- Tracheal and airway disorders
- Liver physiology and pathology
- Meningioma and schwannoma management
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Otolaryngology and Infectious Diseases
- Cancer Research and Treatments
- Facial Nerve Paralysis Treatment and Research
- Glaucoma and retinal disorders
- Voice and Speech Disorders
- Streptococcal Infections and Treatments
- Periodontal Regeneration and Treatments
Tel Aviv Sourasky Medical Center
2019-2025
Tel Aviv University
2019-2025
University Health Network
2015-2024
University of Toronto
2015-2024
Princess Margaret Cancer Centre
2015-2023
Committee on Publication Ethics
2023
Textron Systems (United Kingdom)
2022-2023
National Medical Research Center of Dentistry and Maxillofacial Surgery
2023
Barro Colorado Island
2021
Toronto General Hospital
2020
ABSTRACT Objective To determine whether the subperiosteal abscess (SPA) volume in acute coalescent mastoiditis (ACM) as measured imaging studies, should influence decision‐making process between performing mastoidectomy versus needle aspiration or incision and drainage (I&D) initial treatment of SPA. Setting Single tertiary referral center. Patients Methods The records all pediatric patients admitted with ACM 1/2012 12/2023 were retrospectively reviewed. Baseline volumes on dedicated...
PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles' vascular circulation by mitigating reticuloendothelial system uptake. However, there remain many concerns in regards its immunogenicity, targeting efficiency, etc., which inspires pursuit of alternate, non-PEGylated systems. We introduced here a PEG-free, porphyrin-based ultrasmall nanostructure mimicking nature lipoproteins, termed PLP, that integrates multiple imaging and therapeutic functionalities, including...
Increased CD8-T lymphocytes and reduced natural killer (NK) cells contribute to hepatic fibrosis. We have characterized pathways regulating the interactions of human stellate (HSCs) with specific lymphocyte subsets in vivo vitro. Fluorescence-activated cell sorting (FACS) was used characterize peripheral blood (PBLs) intrahepatic (IHLs) obtained from healthy controls patients either hepatitis B virus (HBV) or C (HCV) advanced Liver sections were analyzed by immunohistochemistry confocal...
Head and neck cancer is the fifth most common type of worldwide remains challenging for effective treatment due to proximity critical anatomical structures in head region, which increases probability toxicity from surgery radiotherapy, therefore emphasizes importance maximizing targeted ablation.We have assessed effectiveness porphysome nanoparticles enhance fluorescence photoacoustic imaging tumors rabbit hamster models.In addition, we evaluated this agent localized photothermal ablative...
J-aggregates display nanoscale optical properties which enable their use in fluorescence and photoacoustic imaging applications.
Abstract Purpose: The low survival rate of head and neck cancer (HNC) patients is attributable to late disease diagnosis high recurrence rate. Current HNC staging has inadequate accuracy sensitivity for effective treatment management. multimodal porphyrin lipoprotein-mimicking nanoparticle (PLP), intrinsically capable positron emission tomography (PET), fluorescence imaging, photodynamic therapy (PDT), shows great potential enhance the potentially Experimental Design: Using a clinically...
Abstract The discovery and synthesis of novel multifunctional organic building blocks for nanoparticles is challenging. Texaphyrin macrocycles are capable chelators. However, they remain elusive as because the difficulty associated with texaphyrin constructs self‐assembly. A manganese (Mn)‐texaphyrin‐phospholipid block described, along its one‐pot self‐assembly into a Mn‐nanotexaphyrin. This nanoparticle possesses strong resilience to dissociation, structural stability, in vivo bio‐safety,...
Abstract Photodynamic therapy (PDT) is a tissue ablation technique able to selectively target tumor cells by activating the cytotoxicity of photosensitizer dyes with light. PDT nonsurgical and sparing, two advantages for treatments in anatomically complex disease sites such as oral cavity. We have previously developed PORPHYSOME (PS) nanoparticles assembled from chlorin photosensitizer–containing building blocks (∼94,000 photosensitizers per particle) capable potent PDT. In this study, we...
Objectives To study the need for defining unilateral idiopathic sudden sensorineural hearing loss (ISSNHL) as an otologic emergency and establish evidence-based cutoff treatment initiation optimal outcome. Methods A systematic literature search of “MEDLINE” via “PubMed,” “Embase,” “Web Science” original case series comparing outcome steroidal ISSNHL a function delays patient presentation, diagnosis, initiation. Total delay was defined days from onset to first dose divided into up 3 days, 7...
Abstract Background The free fibula flap is commonly referred to as a “workhorse” for head and neck reconstruction. During our 21-year experience with this flap, we have performed several changes in preoperative planning, operative technique, postoperative follow-up. Patients Methods A retrospective cohort study designed analyze the of patients who underwent transfer Demographics, medical background, data, outcome were collected. follow-up assessed their impact on discussed. Results 1998...
64 Cu-porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head neck cancer orthotopic rabbit model using positron emission tomography imaging. Additionally, the exhibit selective fluorescence activation in tumor which permits intraoperative real-time visualization disease tissues to precisely define surgical margins prevents collateral damage during surgeries.
While CD8 subsets activate hepatic fibrosis, natural killer (NK) cells exhibit antifibrotic activity. Glatiramer acetate (GA) is an immune modulator for multiple sclerosis. We assessed the potential impact of GA on mouse fibrogenesis. Hepatic fibrosis was induced in C57BL/6 mice by intraperitoneal administration carbon tetrachloride (CCl(4)) 6 wk. During last 2 wk, animals were also treated with either (200 mu/day ip) or medium and compared naive fibrotic (8 animals/group). markedly...
Tissue-type plasminogen activators (tPA) and urokinase-type (uPA) are involved in liver repair. We examined the potential immunomodulatory actions of uPA, tPA uPA-receptor (uPAR) carbon-tetrachloride-induced hepatic fibrosis wild-type (WT), tPA-/-, uPA-/- uPAR-/- mice. Carbon-tetrachloride treatment increased four groups but significantly less three knock-out models. Serum cytokines intrahepatic T cells elevated following process WT animals not groups. In culture, uPA lymphocyte...
Advanced cutaneous squamous cell carcinoma of the head and neck (CSCCHN) is associated with poor outcome despite multimodality therapy. Comprehensive risk stratification may pinpoint most suitable adjuvant treatment. This study aimed to evaluate outcomes surgically treated locoregional CSCCHN identify prognostic indicators treatment outcomes.We retrospectively analyzed disease variables, pathologic characteristics, management in association all consecutive advanced patients who underwent...
The incidence of differentiated thyroid cancer has increased significantly during the last several decades. Surgical resection is primary treatment for and highly effective, resulting in 5-year survival rates greater than 98%. However, surgical can result short- long-term treatment-related morbidities. Additionally, as this malignancy often affects women less 40 years age, there interest more conservative approaches and, an unmet need therapeutic options that minimize risk surgery-related...
Abstract Background The image‐guided operating room (OR) is an emerging standard for dealing with complex cases in many surgical disciplines including neurosurgery, thoracic surgery, maxillofacial trauma, and orthopedic surgery. Its use head neck oncological surgery not well established. primary aim of this study was to assess the image quality cone‐beam CT (CBCT) under real clinical conditions. secondary effect on performance decision making. Methods Intraoperative 3D imaging performed...
Objective: The Harmonic Scalpel (HS) has been recently widely used to perform a variety of surgical procedures. We reviewed our experience with the use HS in superficial parotidectomy determine safety and efficacy this procedure, regard operative time, postoperative facial nerve function, drainage output. Study Design: Nonrandomized retrospective review. Materials Methods: medical records all patients who underwent for benign pathology at Shaare Zedek Medical Center from January 2006 July...