A5005184189- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Optical Imaging and Spectroscopy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Thermography and Photoacoustic Techniques
- Bladder and Urothelial Cancer Treatments
- Endometrial and Cervical Cancer Treatments
- Radiation Dose and Imaging
- Skin Protection and Aging
- Laser-induced spectroscopy and plasma
- Surgical Simulation and Training
- Tracheal and airway disorders
- Spectroscopy and Quantum Chemical Studies
- Soft Robotics and Applications
- Photochemistry and Electron Transfer Studies
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
Princess Margaret Cancer Centre
2015-2024
University of Toronto
2009-2024
University Health Network
2014-2024
Health Net
2020-2023
Toronto Public Health
2020
Sana Klinikum Offenbach
2017
Ontario Institute for Cancer Research
2005-2014
Cancer Institute (WIA)
2014
Toronto Metropolitan University
2008-2013
McGill University Health Centre
2008
We ascertained the feasibility and safety of image guided targeted photothermal focal therapy for localized prostate cancer.Twelve patients with biopsy proven low risk cancer underwent interstitial ablation cancer. The area interest was confirmed using magnetic resonance imaging. Three-dimensional ultrasound used to guide a laser fused interest. Target monitored thermal sensors real-time Definity contrast enhanced ultrasound. Followup performed combination imaging biopsy. Validated quality...
Tookad is a novel intravascular photosensitizer. When activated by 763 nm light, it destroys tumors damaging their blood supply. It then clears rapidly from the circulatory system. To our knowledge we report first application of vascular targeted photodynamic therapy in humans. We assessed safety, pharmacokinetics and preliminary treatment response as salvage procedure after external beam radiation therapy.Patients received escalating drug doses 0.1 to 2 mg/kg at fixed light dose 100 J/cm or...
To report on the efficacy of TOOKAD (WST 09; NegmaLerads, Magny-Les-Hameaux, France) vascular-targeted photodynamic therapy (VTP) as a method whole-prostate ablation in patients with recurrent localized prostate cancer after failure external beam radiotherapy (EBRT).Patients received fixed photosensitizer dose 2 mg/kg and patient-specific light doses determined by computer-aided treatment planning. Up to six cylindrical light-diffusing delivery fibres were placed transperineally under...
Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal. Photosynthetic organisms have evolved ingenious strategies to optimize light absorption nanoscale ordered dye aggregation. Here, we use this concept synthesize a stimuli-responsive nanoswitch with large absorbance and sensing capabilities. Ordered...
With the development of new photosensitizers that are activated by light at longer wavelengths, interstitial photodynamic therapy (PDT) is emerging as a feasible alternative for treatment larger volumes tissue. Described here application PDT planning software developed our group to ensure complete coverage larger, geometrically complex target such prostate. In phase II clinical trial TOOKAD vascular targeted (VTP) prostate cancer in patients who failed prior radiotherapy, was used generate...
To prospectively evaluate the magnetic resonance (MR) imaging appearance of prostate and periprostatic tissues after vascular targeted photodynamic therapy (VTP) with palladium-bacteriopheophorbide for locally recurrent carcinoma external beam radiation therapy.Informed consent was obtained from all patients, approval ethics review boards participating institutions. Nonenhanced T2-weighted dynamic gadolinium-enhanced T1-weighted MR examinations were performed at baseline 1 week, 4 weeks, 6...
Background: This Sawbones and cadaver study was performed to assess the accuracy reproducibility of pelvic bone cuts made with use a novel navigation system navigated osteotome oscillating saw. Methods: Using three-dimensional planning tool, we that were representative typical in tumor resections. The includes prototype mobile C-arm for intraoperative cone-beam computed tomography, real-time optical tracking (Polaris), visualization software. Three-dimensional virtual radiographs utilized...
Abstract Skin photosensitization is a common challenge following intravenous administration of many photodynamic therapy (PDT) drugs, typically lasting days, weeks, or months in laboratory animals and patients. Symptoms photosensitivity manifest as erythema edema on skin exposed to sunlight bright artificial lighting. Recent efforts using nanocarriers increase photosensitizer accumulation tumors have also been shown reduce photosensitivity. We previously developed phototheranostic PORPHYSOME...
Background: The ability of Helium–Neon (He–Ne) laser irradiation a photosensitizer to induce localized phototoxic effects that kill periodontal pathogens is well documented and termed photodynamic therapy (PDT). Objectives: We investigated the potential conventional light source (red‐filtered Xenon lamp) activate toluidine blue O (TBO) in vitro determined model parameters may be used future vivo trials. Materials methods: Porphyromonas gingivalis 381 was as primary test bacterium. Results:...
Abstract— This study compares the photosensitizer concentration measured noninvasively in vivo by diffuse reflectance spectroscopy with results of postmortem tissue solubilization and fluorometric assay. The spectrometer consists a fiber optic surface probe, charge‐coupled device (CCD) array detector. probe has eight detection fibers separated from light source distances ranging 0.85 to 10 mm. imaging disperses each detector onto two‐dimensional CCD array, while maintaining spatial...
This paper reports on the development of a new closed-bore magnetic resonance imaging (MRI) compatible robotic system for image-guided prostatic interventions: ablation, brachytherapy, and biopsy. The first stage addresses only laser-based ablation. robot actuators are ultrasonic motors. physical prototype was manufactured tested in MRI with an ablation tool. tests covered (MR) compatibility, tool visualization, control accuracy. Robot tip position error is less than 2 mm at points closer...
Introduction: We report a case study of the application contrastenhancedultrasonography (CEUS) for intraoperative monitoringof thermal ablation single focus prostate cancer.Methods: A patient presented with biopsy-proven, solitary-focus,low-risk cancer and was recruited into clinical trial ofinterstitial laser focal therapy. Multiparametric magneticresonance imaging (MRI) used to locate dominantfocus, photothermal performed at tumoursite under guidance transrectal ultrasonography....
Measurement of the concentration fluorescent compounds in turbid media is difficult because absorption and multiple scattering excitation emission light has a large effect on detected fluorescence. For surface measurements with optical fibers we demonstrate by experiments numerical simulation that this can be minimized measurement fluorescence at one source–detector distance, diffusely reflected second ratio these two signals as an indicator fluorophore concentration. properties typical soft...