A5089692791- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Effects of Radiation Exposure
- Advanced MRI Techniques and Applications
- Radiation Effects in Electronics
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Nuclear Physics and Applications
- Cancer, Hypoxia, and Metabolism
- Boron Compounds in Chemistry
- Management of metastatic bone disease
- Brain Metastases and Treatment
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Bone Tumor Diagnosis and Treatments
- Mathematical Biology Tumor Growth
- Lanthanide and Transition Metal Complexes
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Quantum Chromodynamics and Particle Interactions
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Particle physics theoretical and experimental studies
German Cancer Research Center
2015-2024
Heidelberg University
2015-2024
DKFZ-ZMBH Alliance
2000-2024
University Hospital Heidelberg
2020-2023
Heidelberger Institut für Radioonkologie
2020-2022
National Center for Tumor Diseases
2020-2021
In-Q-Tel
2020
University of Regensburg
2014-2016
Abstract Accurate Magnetic Resonance Imaging (MRI) simulation is fundamental for high-precision stereotactic radiosurgery and fractionated radiotherapy, collectively referred to as radiotherapy (SRT), deliver doses of high biological effectiveness well-defined cranial targets. Multiple MRI hardware related factors well scanner configuration sequence protocol parameters can affect the imaging accuracy need be optimized special purpose treatment planning. SRT possible different organizational...
Abstract Modern radiotherapy delivers highly conformal dose distributions to irregularly shaped target volumes while sparing the surrounding normal tissue. Due complex planning and delivery techniques, verification validation of whole treatment workflow by end-to-end tests became much more important polymer gel dosimeters are one few possibilities capture delivered distribution in 3D. The basic principles formulations dosimetry its evaluation methods described available studies validating...
Abstract BACKGROUND The authors evaluated whether modern photon techniques, such as stereotactic fractionated radiation therapy (FSRT) or intensity‐modulated RT, outweighed the biologic advantages of high‐linear‐energy transfer RT in treatment patients with locally advanced adenoid cystic carcinomas (ACC) that infiltrated skull base orbit. METHODS Between June 1995 and December 2003, 63 ACC were treated techniques at University Heidelberg. results achieved alone compared combined a carbon...
The clinical implementation and application of a novel treatment planning system (TPS) for scanned ion beams is described, which in use carbon treatments at the German heavy facility (GSI). All plans are evaluated on basis biologically effective dose distributions. For therapy control, in-beam positron emission tomography (PET) an online monitoring beam intensity position used. absence gantry restricts to horizontal beams. Most consist two nearly opposing lateral fields or sometimes...
Accurate and reproducible patient setup is a prerequisite to fractionated radiotherapy. To evaluate the applicability technical performance of commercial 3D surface imaging system for repositioning breast cancer patients, measurements were performed in rigid anthropomorphic phantom as well healthy volunteers. The camera records respiration-gated model imaged object, which may be registered previously recorded reference model. A transformation provided, applied treatment couch correct...
Biological optimization for treatment planning in carbon ion therapy is currently based on the first version of local effect model (LEM I). Further developments implemented latest IV) allowed to predict more accurately Relative Effectiveness (RBE) in-vitro. The main goal this study compare LEM IV against I under treatment-like conditions idealized target geometries. Therefore, physical dose distributions resulting from biological with were used recalculate RBE-weighted distribution IV. Input...
The aim of this work was to determine magnetic field correction factors that are needed for dosimetry in hybrid devices MR-guided radiotherapy Farmer-type ionization chambers different strengths and orientations. response six custom-built irradiated at a 6 MV linac measured water tank positioned magnet with between 0.0 T 1.1 T. Chamber axis, beam were perpendicular each other both directions investigated. EGSnrc Monte Carlo simulations compared the measurements orientations performed. For...
With the rapid increase in clinical treatments with MRI-linacs, a consistent, harmonized and sustainable ground for reference dosimetry MRI-linacs is needed. Specific presence of strong magnetic field. Therefore, existing Code Practices (CoPs) are inadequate. In recent years, vast amount papers have been published relation to this topic. The purpose review paper twofold: give an overview evaluate literature discuss whether datasets adequate complete serve as basis development new or extend...
The introduction of dynamic intensity modulation into radiotherapy using conventional photon beams or scanning particle requires additional and efficient methods dose verification. Dose measurements in dynamically generated distributions with a single ionization chamber require complete application the treatment field for each measurement. Therefore are performed by simultaneous use multiple chambers. measurement is computer controlled system comprised following steps: (a) automated...
Measurements of carbon ion ranges in various phantom materials and real bones are presented. Together with measured Hounsfield values, an empirical relation between units is derived, which important prerequisite for treatment planning therapy.
Abstract BACKGROUND: The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas chondrosarcomas. METHODS: Between 1997 2007, 394 patients were treated RT at Gesellschaft für Schwerionenforschung Darmstadt, Germany. Of these patients, 17 aged ≤21 years. Seventeen for chordoma or low‐grade chondrosarcoma analyzed this study. Irradiation performed after primary diagnosis 14 (82%) recurrent tumors 3 (18%)....