A5102929805- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Autoimmune Neurological Disorders and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Green IT and Sustainability
- Vascular Tumors and Angiosarcomas
- Breast Lesions and Carcinomas
- Oral and gingival health research
National Institutes of Health
2020-2024
National Cancer Institute
2020-2024
Icahn School of Medicine at Mount Sinai
2015-2024
Dartmouth College
2022-2024
Center for Cancer Research
2020-2023
Cornell University
2023
Stony Brook Medicine
2019
University Health Network
2015-2018
Princess Margaret Cancer Centre
2017
Southeast University
2017
The echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene represents a molecular target in small subset of non-small cell lung cancers (NSCLCs). This leads to constitutive ALK activation with potent transforming activity. In pivotal phase 1 clinical trial, the tyrosine inhibitor (TKI) crizotinib (PF-02341066) demonstrated impressive antitumor activity majority patients NSCLC harboring fusions. However, despite these remarkable initial...
In cancer patients, circulating tumour-derived DNA (ctDNA) levels imperfectly reflect disease burden apparent on medical imaging. Further evaluation of ctDNA over time is needed to better understand the correlation with tumour growth and therapeutic response. We describe kinetics within an orthotopic, immunocompetent preclinical rabbit model local-regionally advanced head neck squamous cell carcinoma (HNSCC). Monitoring primary metastatic lymph node volume by computed tomography (CT), we...
Abstract Purpose: Gastrointestinal stromal tumors (GIST) commonly arise in different regions of the stomach and are driven by various mutations (most often KIT, PDGFRA, SDHx). We hypothesized that anatomic location gastric GIST is associated with unique genomic profiles distinct driver mutations. Experimental Design: compared KIT versus non-KIT status tumor within National Cancer Database (NCDB) for 2,418 patients primary GIST. Additionally, we compiled an international cohort (TransAtlantic...
Sustainability has long been a topic of substantial interest to the design and human-centered computing communities. With industries increasingly prioritizing climate targets, there is growing demand for sustainable product design. This article addresses this need through EcoSketch, digital tool designed democratize environmental impact assessments designers. Shifting typically retrospective evaluations early stages development, EcoSketch enables proactive consideration adoption...
Serum pancreastatin is a sensitive and specific diagnostic biomarker in neuroendocrine tumors (NETs). Elevated levels are associated with worse progression-free survival overall small bowel pancreatic NETs. In this study, we investigated the clinical significance of elevated serum identifying metastatic disease to liver.Retrospective chart review patients NET managed at single institution was performed. The site primary tumor, laboratory data, presence were reviewed. sensitivity,...
Targeting CA 19-9 with a humanized monoclonal antibody at the time of surgery may decrease recurrence rates for patients undergoing resections pancreatic cancer, cholangiocarcinoma and metastatic colorectal cancer
Abstract Wild-type KIT and PDGFRA gastrointestinal stromal tumors (GIST) are rare with limited treatment options. We sought to determine the clinicopathologic features of wild-type GIST identify factors that influence overall survival (OS) using a large national database. Retrospective evaluation patients in National Cancer Database (NCDB) was performed. Demographic, clinicopathologic, data were analyzed. Features associated OS investigated Kaplan–Meier analysis Cox proportional hazards...
Guidelines for Stage II colon cancer recommend adjuvant chemotherapy (AC) only tumors with high-risk features, but long-term outcomes data are mixed. We aimed to determine if AC was associated a survival benefit in this population.
Objectives/Hypothesis The endoscopic endonasal approach (EEA) for nasopharyngectomy is an alternative to the maxillary swing (MSA) selected recurrent nasopharyngeal carcinomas (NPC). We compare access between these approaches. Methods Three cadaver specimens were used volumes of EEA and MSA. Exposure calculated using image guidance registration cone beam computed tomography tracking accessible tissue with volumetric quantification. area exposure carotid artery was measured. Results MSA...
Abstract Background and Objectives In 2003, the Society of Surgical Oncology (SSO) initiated a breast surgical oncology fellowship, which has now grown to 60 SSO accredited programs as 2021. Limited knowledge exists on traits successful applicants factors influencing rank list. Methods A web‐based, anonymous survey was sent all Breast Fellowship program directors. The consisted 26 questions. Descriptive statistics were used analyze responses evaluate impact applicant interview Results...
Abstract Cholangiocarcinoma (CCA) is a deadly malignancy with an evolving therapeutic landscape. Although nucleic acid-based evaluations have unveiled some druggable targets, limited options are available for the majority of patients this disease. We therefore evaluated biliary exosomes by mass spectrometry from 16 CCA, which revealed 17-fold enhancement nuclear export protein XPO7 in CCA-derived exosomes. IHC analysis expression CCA tumors 170 unexpectedly demonstrated intense cytoplasmic...
Abstract Spondylarthritis (SpA) is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and spine, peripheral arthritis, enthesitis, dactylitis. SpA can manifest mainly as axial (axSpA) or SpA. AxSpA divided into radiographic spondylarthritis (r-axSpA) non-radiographic (nr-axSpA). The main symptom spondylarthritis, low back pain, often occurs before development sacroiliitis seen on radiographs, this delay persist for many years. People with ankylosing...