A5008286355- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Diversity and Career in Medicine
- Intracranial Aneurysms: Treatment and Complications
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Surgical Simulation and Training
- Cardiovascular Health and Disease Prevention
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Viral-associated cancers and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Nanoparticle-Based Drug Delivery
- Adrenal and Paraganglionic Tumors
- Acute Ischemic Stroke Management
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Research Studies
- Innovations in Medical Education
- Advances in Oncology and Radiotherapy
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Amino Acid Enzymes and Metabolism
- Hospital Admissions and Outcomes
University of Pittsburgh Medical Center
2023-2024
University at Buffalo, State University of New York
2012-2022
Roswell Park Comprehensive Cancer Center
2016-2021
New York University
2021
National Institutes of Health
2018-2020
National Cancer Institute
2018-2020
Center for Cancer Research
2018-2020
Moffitt Cancer Center
2020
Kaleida Health
2013-2016
Limited data exist regarding the use of antiplatelet response assays during neuroendovascular intervention. We report outcomes after carotid artery stenting (CAS) based on aspirin and P2Y12 assays.We retrospectively identified patients who had at time stenting. Aspirin (325 mg) clopidogrel (75 were started 7-10 days pre-intervention. If not possible, (650 (600 loading doses given Assays checked postoperative day 0/1. Outcomes included neurological ischemic sequela 30 days, 1 2 years, as well...
Objective Several studies have reported increased perioperative risk after carotid artery stenting (CAS) for patients ≥80 years of age; however, most not considered unfavorable anatomic features noted more frequently in this population as a confounding variable. The purpose study was to show correlation between poor aortic arch anatomy and ischemic complications CAS. Methods Our prospectively maintained database queried all CAS procedures performed on symptomatic 2009 2011. Retrospective...
BACKGROUND: Demographics and vascular anatomy may play an important role in predicting periprocedural complications symptomatic patients undergoing carotid artery stenting (CAS). OBJECTIVE: To predict factors associated with increased risk of CAS to devise a scoring system that predicts such this patient population. METHODS: A retrospective study was conducted included who underwent for stenosis during 3-year period. anatomic characteristics were subsequently correlated 30-day outcome...
Neuroendocrine tumors (NETs) metastatic to the liver are treated with transarterial radioembolization (TARE) using yttrium-90 (Y-90) microspheres or chemoembolization (TACE). However criteria for patient selection not well defined. We sought determine if Ki67 score could help select patients one therapy over other in management of hepatic neuroendocrine metastases.Single institution analysis Y-90 TACE between 2001 and 2014. Pathologists blinded clinical information performed staining. Data...
Abstract Background/Objectives Gallbladder squamous cell carcinoma (SCC) is an uncommon malignancy whose rarity has made it particularly challenging to study. We utilized a national database shed light on the clinicopathologic characteristics, management patterns, and survival associated with these tumors. Methods Patients gallbladder SCC were identified in National Cancer Database. Clinicopathologic treatment characteristics recorded compared adenocarcinoma for context. Univariate...
Objective Early intervention is desirable in patients presenting with stroke or transient ischemic attack (TIA) referable to carotid artery stenosis because of the high incidence recurrent events within 48 h post-ictus. However, optimal timing performing angioplasty and stenting (CAS) these remains unclear amid concerns for an elevated risk perioperative complications. The primary outcome this study was combined major complications (stroke, myocardial infarction (MI), death) based on CAS...
RATIONALE Bilins are metabolic products of hosts and bacteria on porphyrins, markers health state human waste contamination. Although bilin tandem mass spectrometry reports exist, their fragmentation behavior as a function structure has not been compared, nor examined collision energy. METHODS The bilins generated by positive ion mode electrospray ionization is collision‐induced dissociation (CID). CID quadrupole trap Fourier transform cyclotron resonance (FT‐ICR) spectrometer energy...
Abstract Background Minimally invasive techniques for pancreaticoduodenectomy (PD) are increasing in practice, however, data remains limited regarding perioperative outcomes. Our study sought to compare patients undergoing open (OPD) with those laparoscopic (LPD) or robot‐assisted (RPD). Methods Patients who underwent PD during 2016–2018 were identified from the New York State Planning and Research Cooperative System database. Results Of 1954 identified, 1708 (87.4%) OPD, 165 (8.4%) LPD, 81...
BackgroundAdrenocortical carcinoma (ACC) is an aggressive malignancy that frequently metastasizes to the liver. Given limitations of systemic therapy in this setting, we sought determine characteristics associated with a two-fold increase survival resection/ablation compared reported chemotherapy alone (∼12 months).MethodsPatients who underwent at our institutions for ACC liver metastases were identified. Those survived 12–24 months after metastasectomy excluded, as aim was characterize...
BACKGROUND: Technological advances have resulted in diminishing perioperative complications reported during carotid artery stenting (CAS) trials. Because trial experience lags behind technological advances, an understanding of the incidence after CAS remains flux. OBJECTIVE: In this single-arm, observational study, a contemporary at high-volume academic training center for neuroendovascular surgeons was reviewed to assess morbidity. METHODS: A prospectively maintained database all procedures...
Heat shock proteins (hsp) are intracellular chaperones that possess extracellular immunostimulatory properties when complexed with antigens. A recombinant Hsp110-gp100 chaperone complex vaccine showed an antitumor response and prolonged survival in murine melanoma. phase Ib dose-escalation study of a human advanced-stage melanoma patients was performed to evaluate toxicity, potential clinical response. Patients pretreated, unresectable stage IIIB/C/IV received the protocol; three...
Carotid angioplasty and stenting (CAS) is considered desirable treatment for patients at high risk carotid endarterectomy. Despite a growing elderly population, scant data exist on CAS in nonagenarians. Nonagenarians represent population open endovascular interventions due to unique anatomic physiologic characteristics presenting significant challenges anesthesiologists surgeons. Studies have quantified that symptomatic asymptomatic should survive 2 5 years, respectively, gain benefit from...