A5052116223- Cancer Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Dysphagia Assessment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Surgical site infection prevention
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Hospital Admissions and Outcomes
- Liver physiology and pathology
- Metastasis and carcinoma case studies
- Full-Duplex Wireless Communications
- Adrenal and Paraganglionic Tumors
- Renal cell carcinoma treatment
Moffitt Cancer Center
2023-2024
University of South Florida
2017-2023
National Institutes of Health
2019-2022
Center for Cancer Research
2020-2022
National Cancer Institute
2019-2022
Southern Illinois University School of Medicine
1999
Non‐islet cell tumor hypoglycemia (NICTH) is a rare clinical entity associated with large mesenchymal tumors. Its pathogenesis most commonly mediated by overproduction of “big” insulin‐like growth factor‐2. Here, we present 54‐year‐old male who presented noninsulin‐mediated and 20 cm intra‐abdominal leiomyoma. His hypoglycemic episodes resolved after the resection his tumor. To our knowledge, this only documented case in English literature NICTH leiomyoma patient. due to benign should be...
Targeting CA 19-9 with a humanized monoclonal antibody at the time of surgery may decrease recurrence rates for patients undergoing resections pancreatic cancer, cholangiocarcinoma and metastatic colorectal cancer
Postoperative hypotension frequently occurs after resection of pheochromocytoma and/or paraganglioma (PPGLs). Epidural anesthesia (EA) is often used for pain control in open these tumors; one its side effects hypotension. Our aim to determine if EA associated with an increased risk postoperative PPGLs. We conducted a retrospective review patients who underwent PPGLs at the National Institutes Health from 2004 2019. Clinical and perioperative parameters were analyzed by use EA. The primary...
This study evaluates our complications arising directly or indirectly from placement management of percutaneous endoscopic gastrostomy (PEG) tubes and provides recommendations for avoidance complications. Seventy-one patients received PEG tube by otolaryngologists between January 1991 May 1997. Records were reviewed diagnoses, combined procedures, Addressing potential causes prompted modification technique management. Twenty-three dysphagia/aspiration unrelated to neoplasia, 11 with staging...
<b><i>Purpose:</i></b> The purpose of this study was to compare demographics, symptoms, prior interventions, operation, and outcomes patients who underwent Heller myotomy for esophageal motility disorders epiphrenic diverticulectomy with myotomy. <b><i>Methods:</i></b> We identified all without over an 80-month period. Primary data points included patient presenting intervention, high-resolution manometry, surgery performed rate laparoscopic,...
Abstract Introduction: Metastatic outgrowth and colonization requires that disseminated tumor cells simultaneously compensate for alterations in nutrient availability, counteract oxidative stress, evade host innate adaptive immune surveillance. The mechanistic underpinnings of how these vital processes are coordinated is not understood. Experimental procedures: Using intrasplenic injection (liver metastases) tail vein (lung metastases), we employed a gain-of-function cDNA screen mice to...
Abstract The monocarboxylic acid transporter 4 (Mct-4), a downstream biomarker of hypoxia inducing factor (HIF)-1α, is involved in the cellular response to hypoxia, as indicated by hypoxic element its promoter region. Using tumorsphere assay an vitro 3-dimensional (3D) model generated using 384-well ultra-low attachment (ULA) plates for cell proliferation analysis plate-based image cytometer, we identify that distinct from cells grown under 2-dimensional (2D) normoxic conditions and...
Abstract Introduction: Although liver metastasis is the major cause of pancreatic cancer mortality, mechanisms by which KRAS-driven tumor cells initiate metastatic outgrowth in are unknown. High-throughput next-generation sequencing studies have revealed that driver mutations and copy number alterations highly concordant between matched primary tumors metastases cancer. This suggests leading to colonization involve cooperation many other cellular factors addition mutations. We hypothesize...
Background: Gastric mixed adenoneuroendocrine carcinoma (gMANEC) is a histopathologic diagnosis with at least 30% each of exocrine and endocrine components. Although prognosis thought to be driven by the relative or dominance, gMANEC has been clinically treated as gastric adenocarcinoma (gAC). The overall survival compared neuroendocrine (gNEC) gAC remains undefined. Methods: Using National Cancer Database, patients tumors were queried from 2004 2016 for gMANEC, gNEC, histologies....
Abstract Introduction: Pancreatic cancer remains a challenging disease, with an overall cumulative 5-year survival rate less than 5%. Metastases are responsible for over 90% of cancer-related deaths. Despite significant progress made in drug development, our understanding the mechanisms driving metastatic outgrowth limited. Systematic dissection molecular underlying progression is necessary development new therapeutic strategies. Method: To identify important genes outgrowth, we performed...
TPS4655 Background: Operable hepatopancreatobiliary (HPB) cancers continue to pose significant challenges. Radical resections are rarely curative, and chemotherapy is able reduce tumor recurrence for only a fraction of patients. Despite the obvious advantages extirpation identifiable tumor(s), inflammatory milieu that accompanies surgery obligate time off cytotoxic agents allows activation remote quiescent disseminated cells, leading metastatic recurrence. We conducting study determine...