A5033598859- Indigenous Health, Education, and Rights
- Osteoarthritis Treatment and Mechanisms
- Health disparities and outcomes
- Adolescent and Pediatric Healthcare
- HER2/EGFR in Cancer Research
- Botulinum Toxin and Related Neurological Disorders
- Racial and Ethnic Identity Research
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Circadian rhythm and melatonin
- Geometric and Algebraic Topology
- Photosynthetic Processes and Mechanisms
- Pediatric Pain Management Techniques
- Cancer Research and Treatments
- Gut microbiota and health
- Musculoskeletal pain and rehabilitation
- COVID-19 and Mental Health
- Homotopy and Cohomology in Algebraic Topology
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
- demographic modeling and climate adaptation
- Qualitative Research Methods and Ethics
- Motor Control and Adaptation
- Periodontal Regeneration and Treatments
- Maternal and Perinatal Health Interventions
University of Pittsburgh
2022-2024
University of Auckland
2020-2023
Stanford University
2022-2023
Statistics New Zealand
2023
Boston Children's Hospital
2019-2021
University of Chicago
2019-2020
National Cancer Institute
2019
National University Hospital
2007
Abstract Cancer therapy faces numerous challenges that can limit the effectiveness of treatment. In order to address these key hurdles, such as immunosuppression, tumor heterogeneity, and likelihood resistance, offer longer-lasting control tumor, we’ve developed a novel dual drug ADC (BiADC), BR113, by conjugating an anti-hTrop2 antibody with linker Topoisomerase I inhibitor payload, another immunostimulator payload. The approach combining direct cytotoxic effects ADCs immune-enhancing...
Abstract Pain-related fear is typically associated with avoidance behavior and pain-related disability in youth chronic pain. Youth elevated have attenuated treatment responses; thus, targeted highly warranted. Evidence supporting graded vivo exposure (GET) for adults pain considerable, but just emerging youth. The current investigation represents the first sequential replicated randomized single-case experimental phase design multiple measures evaluating GET pain, entitled Living . A cohort...
As online content becomes ever more visual, the demand for searching by visual queries grows correspondingly stronger. Shop The Look is an shopping discovery service at Pinterest, leveraging search to enable users find and buy products within image. In this work, we provide a holistic view of how built Look, oriented system, along with lessons learned from addressing needs. We discuss topics including core technology across object detection embeddings, serving infrastructure realtime...
Some children with chronic pain struggle fear of pain, avoidance behaviors, and associated disability; however, movement adaptations in the context childhood is virtually unknown. Variability adaptive responses previously observed between individuals might be largely explained by presence problematic psychological drivers (eg, fear, avoidance). The goals this study were to quantify variability gait examine relationships among avoidance, function (perceived objective), variability.This used a...
Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance transforming growth factor-β (TGFβ)-induced hiMPC chondrogenesis. contrast, TGFβ alone is sufficient result in robust chondrogenesis of human primary mesenchymal stromal (hMSCs). Currently, the mechanism underlying this difference between hiMPCs and hMSCs has not been fully...
Article4 June 2020Open Access Source DataTransparent process Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock Lu Hong orcid.org/0000-0001-7812-0617 Graduate Program Biophysical Sciences, University of Chicago, IL, USA Search for more papers by this author Danylo O Lavrentovich orcid.org/0000-0002-8432-9596 Department Chemistry, Archana Chavan School Natural California, Merced, CA, Eugene Leypunskiy orcid.org/0000-0002-3335-1099 Eileen Li...
The COVID-19 pandemic resulted in the complete closure of many university campuses and a rapid shift to online delivery teaching. Understanding student experience learning under these conditions is important inform improvements adaptations continued services. aim this study was examine students’ learning, studying, assessment during investigate association between perceptions measures psychological health. A cohort 391 undergraduate students completed stress, anxiety wellbeing at beginning...
Abstract Transcription factors (TF) are proteins that bind DNA in a sequence-specific manner to regulate gene transcription. Despite their unique intrinsic sequence preferences, vivo genomic occupancy profiles of TFs differ across cellular contexts. Hence, deciphering the determinants TF binding, both and context-specific, is essential understand regulation impact regulatory, non-coding genetic variation. Biophysical models trained on vitro binding assays can estimate affinity landscapes...
The high prevalence of debilitating joint diseases like osteoarthritis (OA) poses a socioeconomic burden. Currently, the available drugs that target disorders are mostly palliative. unmet need for effective disease-modifying OA (DMOADs) has been primarily caused by absence appropriate models studying disease mechanisms and testing potential DMOADs. Herein, we describe establishment miniature synovial joint-mimicking microphysiological system (miniJoint) comprising adipose, fibrous,...
The high prevalence of debilitating joint diseases like osteoarthritis (OA) poses a socioeconomic burden. Currently, the available drugs that target disorders are mostly palliative. unmet need for effective disease-modifying OA (DMOADs) has been primarily caused by absence appropriate models studying disease mechanisms and testing potential DMOADs. Herein, we describe establishment miniature synovial joint-mimicking microphysiological system (miniJoint) comprising adipose, fibrous,...
Abstract The second lumbrical interossei latency difference test (2‐LINT) is a frequently used for diagnosing carpal tunnel syndrome (CTS). Recently, the premotor potential (2‐LUMP) observed with 2‐LINT was identified as median sensory potential. recording therefore not only compares conduction across equidistant and ulnar motor segments, but also registers conduction. In 52 CTS 50 control hands, we tested whether data obtained help to reduce number of tests necessary diagnose CTS. combined...
Abstract Considering the nascent stage of marine conservation communication, little is understood about how best to communicate complex issues, such as ocean acidification (OA), that are remote and invisible. Despite accumulating evidence OA’s adverse effects on ecosystems biota subsequent consequences for human societies, it remains obscure a majority public. This study compared two language styles (narrative expository) determine which was more effective communicating OA diverse audiences....
Abstract Animal studies demonstrate how the gut microbiota influence psychological health and immunity to viral infections through their actions along multiple dynamic pathways in body. Considerable interest exists probiotics reduce stress illness symptoms beneficial effects gut, but translating pre-clinical evidence from animal models into humans remains challenging. We conducted a large trial nurses working during 2020 COVID19 pandemic year establish whether daily ingestion of probiotic...
Background Birth by caesarean section has been shown to alter the composition of early infant gut microbiota and postulated influence cognitive outcomes via gut‐brain axis. Aims To determine whether birth is associated with secondary school educational achievement. Methods Whole‐population administrative data were used from anonymised individual level linkage records health information New Zealand Integrated Data Infrastructure (IDI). Participants 111 843 children born between 1 January 1996...
Background Nurses are a critical component of any healthcare system. The novel coronavirus pandemic has resulted in an increased workload for nurses and heightened stress. Aims To assess the psychological health over time working during COVID-19 to examine factors associated with stress, anxiety, wellbeing. Methods enrolled study between 2 July 26 August 2020 andcompleted questionnaires about wellbeing at baseline second point T2 12 weeks later. A paired sample t-test was used whether...
Supposing that a hyperbolic knot in S 3 admits finite surgery, Boyer and Zhang proved the surgery slope must be either integral or half-integral, they conjectured latter case does not happen. Using correction terms Heegaard Floer homology, we prove if half-integral then have same homology as one of eight non-hyperbolic knots which are known to admit such surgeries, resulting manifold ten spherical space forms. As carries lot information about knot, this gives strong evidence Boyer–Zhang's conjecture.
Studies suggest that bioactive compounds such as probiotics may positively influence psychological health. This study aimed to determine whether supplementation with the probiotic Lacticaseibacillus rhamnosus HN001 reduced stress and improve wellbeing in university students sitting examinations.In this randomized, double-blind, placebo-controlled study, 483 undergraduate received either L. HN001, or placebo, daily during a semester. Students completed measures of stress, anxiety, at baseline...
Suppose that a hyperbolic knot in $S^3$ admits finite surgery, Boyer and Zhang proved the surgery slope must be either integral or half-integral, they conjectured latter case does not happen. Using correction terms Heegaard Floer homology, we prove if half-integral then have same homology as one of eight non-hyperbolic knots which are known to admit such surgeries, resulting manifold ten spherical space forms. As carries lot information about knot, this gives strong evidence Boyer--Zhang's...
Policies increasingly reinforce the self-determination of Indigenous peoples, but issues remain around group definitions. Colonization has led to (de)identification with Māori (New Zealand's peoples) identity markers. We explore differences between on combinations descent, ethnicity and Iwi (extended kinship group) knowledge in 2013 Census, self-reported discrimination. There were six groups within descent population: two did not know their – some identified solely as (2.8 per cent) or plus...
Understanding content at scale is a difficult but important problem for many platforms. Many previous studies focus on understanding to optimize engagement with existing users. However, little work how leverage better attract new In this work, we build framework generating natural language annotations and show they can be used search engine optimization. The proposed relies an XGBoost model that labels "pins" high probability phrases, logistic regression layer learns rank aggregated groups...
Background Very little high quality evidence exists on the causal relationship between income poverty and childhood health. We provide a comprehensive overview of association household hospitalisations for children. Methods used New Zealand’s Integrated Data Infrastructure (IDI) to link data from Survey Family, Income Employment (SoFIE; n = 21,759 households) 2013 Zealand Census (n 523,302 publicly funded hospital records children aged 0–17 (SoFIE: 39,459; Census, 986,901). Poverty was...
Abstract Introduction: Metastatic outgrowth and colonization requires that disseminated tumor cells simultaneously compensate for alterations in nutrient availability, counteract oxidative stress, evade host innate adaptive immune surveillance. The mechanistic underpinnings of how these vital processes are coordinated is not understood. Experimental procedures: Using intrasplenic injection (liver metastases) tail vein (lung metastases), we employed a gain-of-function cDNA screen mice to...
Abstract Antibody-drug conjugates (ADCs) are emerging therapeutic agents for targeted cancer treatment with remarkable clinical success. However, tumor heterogeneity and microenvironment complexity still the major factors contributing to drug resistance, recurrence, metastasis, which cannot be resolved a mono therapy strategy. We’ve developed novel dual ADC (BiADC), BR113, by conjugating an anti-hTrop2 antibody linker of Topoisomerase I inhibitor payload, another immune stimulator. Our...
How can we lower barriers to reuse of linked administrative data and improve quality at the same time? Linked resources are expensive complex, but accompanying readily-accessible metadata supports control. However, systems that unsystematic or non-automated lead inconsistencies, making use difficult even for experienced analysts. Our national statistics office (NSO) maintains a research database (RD) datasets linkable individual level. With NSO’s agreement, extracted schema information (e.g....