A5046912865- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Osteoarthritis Treatment and Mechanisms
- Neonatal and fetal brain pathology
- Mesenchymal stem cell research
- Lanthanide and Transition Metal Complexes
- Optical Imaging and Spectroscopy Techniques
- Neurological Disease Mechanisms and Treatments
- Bone Tissue Engineering Materials
- Fetal and Pediatric Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Printing in Biomedical Research
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Graphene and Nanomaterials Applications
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Infectious Encephalopathies and Encephalitis
Zhejiang University
2023-2025
Johns Hopkins Medicine
2018-2024
Johns Hopkins University
2018-2024
Fujian University of Technology
2024
Shanghai Jiao Tong University
2017-2024
Shandong Sport University
2024
Shanghai Sixth People's Hospital
2023-2024
East China University of Science and Technology
2024
First Affiliated Hospital of Henan University
2024
Guangdong University of Technology
2023
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early biomarker in human cognitive impairment. However, the relationship between BBB and brain pathology, most commonly Alzheimer disease (AD) vascular disease, is still poorly understood. The present study measured function mild impairment (MCI) patients on 2 molecular scales, specifically BBB's permeability water albumin molecules. Methods Fifty‐five elderly participants were enrolled, including 33 MCI 22 controls....
Osteoarthritis (OA) is a chronic disease mainly characterized by degenerative changes in cartilage, but other joint elements such as bone are also affected. To date, there no disease-modifying OA drugs (DMOADs), owing part to deficiency of current models simulating pathologies and etiologies humans. In this study, we aimed develop microphysiological osteochondral (OC) tissue chips derived from human induced pluripotent stem cells (iPSCs) model the OA. We first iPSCs into mesenchymal...
Abstract A GGGGCC hexanucleotide repeat expansion in intron 1 of chromosome 9 open reading frame 72 ( C9ORF72 ) gene is the most common genetic cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Repeat-associated non-ATG translation dipeptide proteins (DPRs) contributes to neuropathological features c9FTD/ALS. Among five DPRs, arginine-rich poly-PR are reported be toxic. Here, we generate a transgenic mouse line that expresses (GFP-PR 28 specifically neurons. GFP-PR...
Abstract Diseases of the knee joint such as osteoarthritis (OA) affect all elements. An in vitro human cell‐derived microphysiological system capable simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis diseases and testing potential therapeutics. Herein, a mesenchymal stem miniature (miniJoint) generated, which engineered osteochondral complex, synovial‐like fibrous tissue, adipose are integrated into microfluidics‐enabled bioreactor. This novel...
An ideal implant needs to have the ability coordinate foreign body response and tissue regeneration. Here, Hydrogenated-silicon nanosheets (H-Si NSs) with favorable biodegradability are integrated functionalized into a β-tricalcium phosphate scaffold TCP) for bone defect healing. H-Si TCP can greatly improve regeneration through osteoimmunomodulation-guided biodegradation in vivo. The spatiotemporal regulation of degradation products replenishes sufficient nutrients step by entire process...
Purpose Many brain diseases are associated with an alteration in blood‐brain barrier (BBB) and its permeability. Current methods using contrast agent primarily sensitive to major leakage of BBB macromolecules, but may not detect subtle changes The present study aims develop a novel non‐contrast MRI technique for the assessment permeability water. Methods central principle is that by measuring arterially labeled blood spins drained into cerebral veins, water extraction fraction ( E )...
<h3>Objective</h3> To determine whether MRI-based cerebrovascular reactivity (CVR) can predict cognitive performance independently of Alzheimer pathologic markers, we studied the relationship between cognition, CVR, and CSF-derived β-amyloid<sub>42</sub> (Aβ<sub>42</sub>) tau in a group elderly individuals with mixed vascular impairment dementia. <h3>Methods</h3> This was cross-sectional study 72 participants 69 ± 8 years age consisting normal cognition (n = 28) 44) (including 36 mild [MCI]...
Background Cerebrovascular reserve, the potential capacity of brain tissue to receive more blood flow when needed, is a desirable marker in evaluating ischemic risk. However, current measurement methods require acetazolamide injection or hypercapnia challenge, prompting clinical need for resting-state (RS) oxygen level–dependent (BOLD) functional MRI data measure cerebrovascular reactivity (CVR). Purpose To optimize and evaluate an RS CVR technique demonstrate its relationship neurosurgical...
Blood-brain barrier (BBB) plays a critical role in protecting the brain from toxins and pathogens. However, vivo tools to assess BBB permeability are scarce often require use of exogenous contrast agents. In this study, we aimed develop non-contrast arterial-spin-labeling (ASL) based MRI technique estimate water mice. By determining relative fraction labeled spins that were exchanged into tissue as opposed those remained cerebral veins, estimated indices global including extraction (E)...
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well their concurrence, represent the most common types of dysfunction. Treatment strategies for these two conditions are quite different; however, there exists a considerable overlap in clinical manifestations, biomarkers reveal similar abnormalities between conditions. Purpose To evaluate potential cerebral oxygen extraction fraction (OEF) biomarker differential diagnosis VCI. We hypothesized that OEF will be...
Growing evidence suggests that Alzheimer's disease (AD) has been linked with the dysfunction of glymphatic system. Previous studies were primarily cross-sectional and focused on only one specific component, hindering understanding overall function in AD. We evaluated longitudinal changes multiple components system (blood-brain barrier (BBB) transcytolemmal water exchange (TWE) permeability) AD mice. Five female wild-type four 3 × Tg-AD mice from 5 to 13 months age scanned monthly using two...
Abstract Introduction Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery and consumption. We longitudinally measured OEF in older adults to examine relationship with markers of Alzheimer's disease (AD) vascular pathology. Methods One hundred thirty‐seven participants were studied at two time‐points an interval 2.16 years. was using T 2 ‐relaxation‐under‐spin‐tagging (TRUST) magnetic resonance imaging (MRI). The association risks, white matter hyperintensities...
Cerebrovascular reactivity (CVR) mapping using CO2-inhalation can provide important insight into vascular health. At present, blood-oxygenation-level-dependent (BOLD) MRI acquisition is the most commonly used CVR method due to its high sensitivity, spatial resolution, and relatively straightforward processing. However, large variations in across subjects different sessions of same subject are often observed, which cloud ability this promising measure detecting diseases or monitoring...
Cerebrovascular reactivity (CVR), an index of brain vessel's dilatory capacity, is typically measured using hypercapnic gas inhalation or breath-holding as a vasoactive challenge. However, these methods require considerable subject cooperation and could be challenging in clinical studies. More recently, there have been attempts to use resting-state BOLD data map CVR by utilizing spontaneous changes breathing pattern. subjects who small fluctuations their pattern, the results noisy...
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). DJ-1 acts essential roles neuronal protection and anti-neuroinflammatory response, its loss function tightly associated with a familial recessive form PD. However, molecular mechanism involved neuroinflammation largely unclear. Here, we found that wild-type DJ-1, rather than pathogenic L166P mutant...
Abstract Purpose To create an inventory of image processing pipelines arterial spin labeling (ASL) and list their main features, to evaluate the capability, flexibility, ease use publicly available guide novice ASL users in selecting optimal pipeline. Methods Developers self‐assessed using a questionnaire developed by Task Force 1.1 ISMRM Open Science Initiative for Perfusion Imaging. Additionally, each pipeline was evaluated two independent testers with basic experience scoring system...