A5071047632- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Gastric Cancer Management and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiac tumors and thrombi
- Lanthanide and Transition Metal Complexes
- Acute Ischemic Stroke Management
- Vascular Tumors and Angiosarcomas
- Ear Surgery and Otitis Media
- Child and Animal Learning Development
- Cancer-related gene regulation
- Natural Fiber Reinforced Composites
- Neuroscience and Music Perception
- Esophageal and GI Pathology
- RNA regulation and disease
- Diet and metabolism studies
- melanin and skin pigmentation
- Tribology and Wear Analysis
- EEG and Brain-Computer Interfaces
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
Xihua University
2025
Hubei University of Medicine
2018-2024
Huawei Technologies (China)
2024
Shanghai Institute of Materia Medica
2023-2024
Chinese Academy of Sciences
2023-2024
Air Force Medical University
2024
Anhui Medical University
2023
Wuhu Fourth People Hospital
2023
First Affiliated Hospital of Anhui Medical University
2023
South China Normal University
2021-2023
The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent fMRI resting-state datasets to regional cortical a newly generated RNA-seq dataset additional obtain robust reproducible correlations. We find significantly more genes correlated with fALFF than expected chance specific imaging signals...
Purpose Assessment of brain hemodynamics without exogenous contrast agents is increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide noncontrast and multiparametric estimation hemodynamic markers. Methods We devised arterial spin labeling (ASL) method based on the principle fingerprinting (MRF), referred as MRF‐ASL. By taking advantage rich information contained MRF sequence, up seven parameters be estimated concomitantly....
Disorders of brain metabolism are multiform in their mechanisms and manifestations, many which remain insufficiently understood thus similarly treated. Glucose transporter type I deficiency (G1D) is commonly associated with seizures electrographic spike-waves. The G1D syndrome has long been attributed to energy (ie, adenosine triphosphate synthetic) failure such as that consequent tricarboxylic acid (TCA) cycle intermediate depletion. Indeed, glucose other substrates generate TCAs via...
Purpose Many brain diseases are associated with an alteration in blood‐brain barrier (BBB) and its permeability. Current methods using contrast agent primarily sensitive to major leakage of BBB macromolecules, but may not detect subtle changes The present study aims develop a novel non‐contrast MRI technique for the assessment permeability water. Methods central principle is that by measuring arterially labeled blood spins drained into cerebral veins, water extraction fraction ( E )...
Abstract The introduction of poly‐ p ‐hydroxybenzoate (PHB) and fibrous wollastonite can effectively improve the comprehensive properties polytetrafluoroethylene (PTFE)‐based composites, but its are significantly influenced by hot‐pressing pressure during sintering. In this article, PTFE/fibrous wollastonite/PHB composites were prepared using different pressures, that is, 0, 20, 40, 60, 80 MPa. relationship between morphology, compressive strength, creep deformation tribological PTFE...
Cerebrovascular reactivity (CVR) mapping using CO2-inhalation can provide important insight into vascular health. At present, blood-oxygenation-level-dependent (BOLD) MRI acquisition is the most commonly used CVR method due to its high sensitivity, spatial resolution, and relatively straightforward processing. However, large variations in across subjects different sessions of same subject are often observed, which cloud ability this promising measure detecting diseases or monitoring...
Purpose Cerebral venous oxygenation (Y v ) is an important physiological parameter and has potential clinical application in many brain diseases. T 2 ‐relaxation‐under‐spin‐tagging (TRUST) a commonly used MRI method to measure Y . Harmonization of this technique across vendors for dissemination multicenter studies metabolism as disease biomarker. Methods TRUST pulse sequence components imaging parameters were carefully matched between two major vendors, Philips Siemens. Each subject ( N =...
Promoters are essential tools for basic and translational neuroscience research. An ideal promoter should possess the shortest possible DNA sequence with cell-type selectivity. However, whether ultra-compact promoters can offer neuron-specific expression is unclear. Here, we report development of an extremely short that enables selective gene in neurons, but not glial cells, brain. The originates from human CALM1 only 120 bp size. (pCALM1) embedded adeno-associated virus (AAV) genome...
Abstract This case report describes a 35‐year‐old female patient who presented with palpitations and shortness of breath. Imaging findings suggested cardiac tumor, histopathology confirmed primary angiosarcoma. tumor is highly aggressive, usually occurs in the right atrium, lacks specificity clinical presentation, prone to early metastasis, has poor prognosis. Echocardiography method choice for detection important assessing size, location, mode attachment whether function impaired.
A better understanding of the effect oxygen on brain electrophysiological activity may provide a more mechanistic insight into clinical studies that use treatment in pathological conditions, as well to calibrate functional magnetic resonance imaging (fMRI) signals. This study applied electroencephalography (EEG) healthy subjects and investigated how high concentration inhaled air (i.e., normobaric hyperoxia) alters under resting-state task-evoked conditions. Study 1 its impact resting EEG...
Purpose Cerebral venous blood oxygenation (Y v ) is an important biomarker in brain physiology and function. The present study proposes a procedure to provide quantitative map of the brain's intravascular Y . Theory Methods method based on pulse sequence, T 2 ‐Relaxation‐Under‐Phase‐Contrast (TRU‐PC) MRI, with postprocessing approaches correct eddy‐current effects. A complete scan protocol consists four TRU‐PC scans sensitized large small vessels anterior–posterior foot–head flow‐encoding...
Abstract The anterior cingulate cortex (ACC) serves as a core region in social networks, and impairments this area have been identified autism spectrum disorders. Our prior research demonstrated that deficits pyramidal neurons ACC adversely impacted mouse interaction. preservation of functional output the by relies on dynamic regulation different types interneurons. However, precise regulatory roles distinct interneurons within shaping interaction hitherto remained largely enigmatic. In...
Purpose Arterial‐spin‐labeling (ASL) magnetic resonance imaging (MRI) is intrinsically a low signal‐to‐noise ratio (SNR) technique. This study aims to enhance its sensitivity by quantifying physiological noise attributed cardiac pulsation and devising an improved sequence, cardiac‐triggered ASL, minimize this noise. Methods A total of 16 healthy subjects were studied on 3 Tesla MRI system. The influence pseudo‐continuous ASL (pCASL) signal was first investigated performing regular pCASL...
Purpose Cerebral venous oxygenation (Y v ) is an important biomarker for brain diseases. This study aims to develop ‐based MR oximetry that can measure cerebral Y in 3D. Methods technique separates blood signal from tissue by velocity‐encoding phase contrast and measures the of pure multi‐gradient‐echo acquisition. The was converted using ‐versus‐oxygenation (Y) calibration curve, which obtained vitro bovine experiments. Reproducibility, sensitivity, validity, resolution dependence were...
Subjective tinnitus, or ringing sensation in the ear, is a common disorder with no accepted objective diagnostic markers.The purpose of this study was to identify possible markers tinnitus by combining audiological and imaging-based techniques.Case-control studies.Twenty adults drawn from our audiology clinic served as participants. The group consisted ten participants chronic bilateral constant control history tinnitus. Each participant closely matched on basis age, gender, hearing...
Background: Tinnitus, or ringing in the ears, is an extremely common ear disorder. However, it a phenomenon that very poorly understood and has limited treatment options. Purpose: The goals of this case study were to identify if antioxidant acetyl-L-carnitine (ALCAR) provides relief from tinnitus, subjective satisfaction after carnitine accompanied by changes audiological imaging measures. Research Design: Case Study. Patient Case: A 41-yr-old female with history hearing loss tinnitus was...
Abstract Malignant melanoma (MM) is notorious for its high metastatic potential, with cardiac metastasis being particularly severe as it involves structures and can lead to significant functional issues. While there no standardized treatment approach, early detection intervention improve prognosis.
To investigate the effects of two kinds surgical resection schemes, a conventional open scheme and thoracolaparoscopic esophagectomy scheme, on operation-related clinical indexes, inflammatory cytokines complications in elderly patients with esophageal cancer.A total 100 cancer seen Department Cardiothoracic Vascular Surgery, Renmin Hospital, Hubei University Medicine, from June 2014 to 2016 were enrolled randomly divided into groups, including control group (50 patients) an observation...
SUMMARY The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations by comparing fractional Amplitude of Low Frequency Fluctuations (fALFF) from two independent fMRI resting state datasets to regional cortical a newly generated RNA-seq dataset additional obtain robust reproducible correlations. We find significantly more genes correlated with fALFF than expected chance, specific imaging...