A5021826825- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Extraction and Separation Processes
- Energy and Environment Impacts
- Building Energy and Comfort Optimization
- Energy, Environment, and Transportation Policies
- Periodontal Regeneration and Treatments
- Recycling and utilization of industrial and municipal waste in materials production
- IoT and Edge/Fog Computing
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Air Quality and Health Impacts
- Photopolymerization techniques and applications
- Sustainable Building Design and Assessment
- Disaster Management and Resilience
- Peroxisome Proliferator-Activated Receptors
- Climate Change, Adaptation, Migration
- Amyotrophic Lateral Sclerosis Research
- COVID-19 and Mental Health
- Urban Heat Island Mitigation
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Muscle Physiology and Disorders
University of Utah
2022-2024
University of Alabama
2024
Chongqing Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2024
Dalian Medical University
2024
Purdue University West Lafayette
2022
Kunming University of Science and Technology
2022
University of Pittsburgh
2019-2022
Central South University
2016-2019
Xiangya Hospital Central South University
2016-2019
MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer.A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found Gene Expression Omnibus (GEO) database and through systematic search PubMed Web Science. The pooled odds ratio (OR) hazard (HR) with 95% CI (Confidence interval) were used to judge value biomarkers.A total 28 studies included this meta-analysis,...
The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. aim of this study was to investigate the related gene biosignatures in OA, and analyze on underlying mechanisms OA.
Natural disasters (e.g., winter storms, heat waves, and hurricanes) threaten residents' energy services due to associated limited power supply or even outages. Maintaining the desired level of residential is critical. However, it still unclear about importance each service residents during how these differ from normal days. In this study, we developed distributed a large-scale survey Texas investigate perceived different end-uses disaster situations. The results illustrate that disasters,...
To investigate the safety, pharmacokinetics (PK), binding activity and immunogenicity of CR002, a human monoclonal antibody (mAb) directed against platelet-derived growth factor-D (PDGF-D), administered as single intravenous (i.v.) infusion over range doses.40 healthy male subjects received increasing doses CR002 at 0.3, 1, 3, 10, 30 mg/kg or placebo.This was randomized, double-blind, placebo-controlled, dose-escalation Phase I study. The trial had duration 90 days, with dosing on Day 1...
Abstract Mesenchymal stem cells (MSCs) represent a promising cell source to regenerate injured cartilage. In this study, MSCs are cultured under confluent conditions for 10 days optimize the deposition of extracellular matrix (mECM), which will serve as scaffold support MSC chondrogenesis. Subsequently, MSC‐impregnated mECM (MSC‐mECM) composite is briefly treated with trypsin, allowing adopt round morphology without being detached from their own mECM. The constructs then in chondrogenic...
Progranulin (PGRN) is a multifunctional growth factor involved in many physiological processes and disease states. The apparent protective role of PGRN the importance chondrocyte autophagic function progression osteoarthritis (OA) led us to investigate regulation autophagy. knockout chondrocytes exhibited deficient response with limited induction following rapamycin, serum starvation, IL-1β-induced PGRN-mediated anabolism suppression catabolism were largely abrogated presence BafA1 autophagy...
Abstract Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life patients due to its disabling pain-causing properties. ER stress has been reported be closely related progression OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which highly expressed in chondrocytes OA patients, promotes degradation refolding abnormal proteins during maintains stability environment...
Osteoarthritis (OA) is a degenerative bone disease associated with ageing, characterized by joint pain, stiffness, swelling and deformation. Currently, pharmaceutical options for the clinical treatment of OA are very limited. Circular RNAs(cirRNAs) have garnered significant attention in related drug development due to their unique RNA sequence characteristics.Therefore,exploring role cirRNAs occurrence paramount importance effective medications OA.
Abstract Duchenne muscular dystrophy (DMD) is a severe X-linked inherited disorder characterized by the loss of dystrophin. We have previously shown that monogene therapy using mini-dystrophin gene improves muscle function in DMD. However, chronic inflammation plays an important role progressive degeneration DMD as well. Vascular endothelial growth factor (VEGF) has been used to enhance vasculature, reduce local and improve function. Temporalis muscles are key skeletal for mastication their...
Residential buildings account for over 20% of total energy consumption in the US, with heating, ventilation, and air conditioning (HVAC) consuming most energy. However, there is little research that comprehensively explores how different influential factors affect space heating (SPH) cooling (SPC) separately. Therefore, based on RECS 2015, this study investigates influencing HVAC usage single-family detached houses, differentiating SPH SPC. Random forest regression multiple linear are...
Effective and biocompatible fixation of implants into cartilage defects has yet to be successfully achieved. [Poly-d,l-lactic acid/polyethyleneglycol/poly-d,l-lactic acid] (PDLLA-PEG) is a chondrosupportive scaffold that photocross-linked using the visible-light photoinitiator lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). Interestingly, LAP its monomer DLLA-EG are able infiltrate form hydrogels upon detection light. After infiltration implant host cartilage, an interconnected...
Long noncoding RNA(lnc RNA) play important roles in cancer progression. HOX transcript antisense RNA(HOTAIR) was observed upregulated a variety of tumors. Over-expression HOTAIR is poor prognostic factor. interacts with Polycomb Repressive complex 2(PRC2), resulting histone H3tri-methylated atlysine27(H3K27me3), which silences the expression some down-stream genes, such as WIF-1,PTEN and p21, then mediated Wnt, Akt p53 signaling pathways transduction. As result, properties tumor, including...
With the continuous advancement of urbanization, problem urban domestic wastewater has become increasingly serious. Furthermore, information and communication technologies (ICTs) have flourished, providing smart ideas for governance problems, including (SUDW), to improve efficiency deliver cities. The framework is vital planning development, but existing frameworks lack systematic characteristics. Therefore, this study aimed systematically analyze functions that SUDW can achieve from a...
United States (US) residential buildings demonstrate great decarbonization and energy-saving potential. However, research on the carbon footprint of at state level, especially consumption-based emissions, is limited. Therefore, this paper aims to quantify compare state-level emissions energy consumption in US. Specifically, emission factors electricity are estimated using area population-based interpolations eGRID regional factors. Total intensity (e.g., per household/ capita) each then...
Maintaining household energy services (e.g., cooking, space heating/cooling, water heating) within an acceptable and affordable level is critical for resilience in extreme weather events winter storms, heat waves) with power shortages or outages. However, the research on importance different levels of compromise diverse services, changes HVAC usage behaviors, willingness to pay (WTP) during disasters limited. This study investigates compromisable WTP, as three key dimensions resilience, both...
In article number 1900229, Rocky S. Tuan, Hang Lin, and co-workers demonstrate that the mesenchymal stem cell-impregnated extracellular matrix (MSC-mECM) may be an efficacious cell-based product for repair of hyaline cartilage injury without use exogenous scaffolds. Human MSCs are cultured under confluent conditions deposition mECM. Subsequently, MSC-impregnated mECM composite is briefly treated with trypsin, allowing to adopt a round morphology being detached from their own Interestingly,...