A5061819704- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Electrolyte and hormonal disorders
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Thermoregulation and physiological responses
- Receptor Mechanisms and Signaling
- RNA Interference and Gene Delivery
- Schizophrenia research and treatment
- Animal testing and alternatives
- Obesity, Physical Activity, Diet
- Animal Genetics and Reproduction
- Public Administration and Political Analysis
- DNA and Nucleic Acid Chemistry
- Genomics and Phylogenetic Studies
- Renal and related cancers
- Sodium Intake and Health
Johns Hopkins University
2023
Invitae (United States)
2023
University of Chicago
2017-2020
Previously published comparative functional genomic data sets from primates using frozen tissue samples, including many our own group, were often collected and analyzed nonoptimal study designs analysis approaches. In addition, when samples multiple tissues studied in a framework, individuals confounded. We designed multitissue of gene expression DNA methylation that minimizes confounding effects by balanced design with respect to species, tissues, individuals. also developed pipeline biases...
A growing body of evidence supports the notion that variation in gene regulation plays a crucial role both speciation and adaptation. However, comprehensive functional understanding mechanisms underlying regulatory evolution remains elusive. In primates, one missing pieces information towards better is comparative annotation interactions between distal elements promoters. Chromatin conformation capture technologies have enabled genome-wide quantifications such 3D interactions. relatively...
Comparative genomic studies in primates have the potential to reveal genetic and mechanistic basis for human specific traits. These may also help us better understand inter-species phenotypic differences that are clinically relevant. Unfortunately, obvious limitation on sample collection experimentation humans non-human apes severely restrict our ability perform dynamic comparative primates. Induced pluripotent stem cells (iPSCs), their corresponding differentiated cells, provide a suitable...
Inter-individual variation in gene expression has been shown to be heritable and is often associated with differences disease susceptibility between individuals. Many studies focused on mapping associations genetic regulatory variation, yet much less attention paid the evolutionary processes that shape observed regulation individuals humans or any other primate. To begin addressing this gap, we performed a comparative analysis of variability quantitative trait loci (eQTLs) chimpanzees, using...
There is substantial interest in the evolutionary forces that shaped regulatory framework early human development. Progress this area has been slow because it difficult to obtain relevant biological samples. Induced pluripotent stem cells (iPSCs) may provide ability establish vitro models of and non-human primate developmental stages.
To investigate the safety, pharmacokinetics (PK), binding activity and immunogenicity of CR002, a human monoclonal antibody (mAb) directed against platelet-derived growth factor-D (PDGF-D), administered as single intravenous (i.v.) infusion over range doses.40 healthy male subjects received increasing doses CR002 at 0.3, 1, 3, 10, 30 mg/kg or placebo.This was randomized, double-blind, placebo-controlled, dose-escalation Phase I study. The trial had duration 90 days, with dosing on Day 1...
Thirteen polydipsic and 40 nonpolydipsic chronic schizophrenic patients received the dexamethasone suppression test while stabilized on psychotropic medication regimens. Thirty-eight percent (N = 5) of those with polydipsia but only 5% 2) without were nonsuppressors cortisol (i.e., had an abnormal response). It is suggested that hippocampal dysfunction could cause both dysregulation in these patients.
Abstract A growing body of evidence supports the notion that variation in gene regulation plays a crucial role both speciation and adaptation. However, comprehensive functional understanding mechanisms underlying regulatory evolution remains elusive. In primates, one missing pieces information towards better is comparative annotation interactions between distal elements promoters. Chromatin conformation capture technologies have enabled genome-wide quantifications such 3D interactions....
Abstract There is substantial interest in the evolutionary forces that shaped regulatory framework established early human development. Progress this area has been slow because it difficult to obtain relevant biological samples. Inducible pluripotent stem cells (iPSCs) provide ability establish vitro models of and non-human primate developmental stages. Using matched iPSC panels from humans chimpanzees, we comparatively characterized gene changes through a four-day timecourse differentiation...
Abstract Previously published comparative functional genomic data sets from primates using frozen tissue samples, including many our own group, were collected and analyzed non-optimal study designs analysis approaches. In addition, when samples multiple tissues studied in a framework, individual confounded. We designed multi-tissue of gene expression DNA methylation that minimizes confounding effects by balanced design with respect to species, tissues, individuals. also developed pipeline...
Abstract Inter-individual variation in gene expression has been shown to be heritable and it is often associated with differences disease susceptibility between individuals. Many studies focused on mapping associations genetic regulatory variation, yet much less attention paid the evolutionary processes that shape observed regulation individuals humans or any other primate. To begin addressing this gap, we performed a comparative analysis of variability quantitative trait loci (eQTLs)...