A5063881405- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- RNA Interference and Gene Delivery
- Digital Imaging for Blood Diseases
- Single-cell and spatial transcriptomics
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Cell Image Analysis Techniques
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic and rare skin diseases.
- Renal cell carcinoma treatment
- Lymphadenopathy Diagnosis and Analysis
- Diphtheria, Corynebacterium, and Tetanus
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Diagnosis and Treatment
Yuxian People's Hospital
2025
Brown University
2022-2024
Providence College
2024
John Brown University
2023
Columbia University Irving Medical Center
2022
Longgang Central Hospital
2018
Roswell Park Comprehensive Cancer Center
2018
Tufts Medical Center
2015-2016
Tufts University
2015-2016
The University of Texas MD Anderson Cancer Center
2012-2015
Abstract Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little currently known about the mutations that drive aggressive cSCC. Experimental Design: Whole-exome sequencing was performed on 39 cases of cSCC to identify driver genes novel therapeutic targets. Significantly, mutated were identified with MutSig or complementary methods developed specifically candidate tumor suppressors based upon their inactivating mutation bias....
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation copy number, RNA, protein expression), we classified 894 renal cell carcinomas (RCCs) various histologic types into nine major genomic subtypes. Site origin within nephron was one determinant in classification, reflecting differences among clear cell, chromophobe, papillary RCC. Widespread changes associated with TFE3 gene fusion or chromatin modifier genes were present a specific...
Highlights•SCCs show chromosome or methylation alterations affecting multiple related genes•These regulate squamous stemness, differentiation, growth, survival, and inflammation•Copy-quiet SCCs have hypermethylated (FANCF, TET1) mutated (CASP8, MAPK-RAS) genes•Potential targets include ΔNp63, WEE1, IAPs, PI3K-mTOR/MAPK, immune responsesSummaryThis integrated, multiplatform PanCancer Atlas study co-mapped identified distinguishing molecular features of cell carcinomas (SCCs) from five sites...
Epidemiologic studies have identified an increasing incidence of squamous cell carcinoma the oral tongue (SCCOT) in younger patients.
Abstract A duplicated gall bladder is a rare congenital biliary anomaly, with an incidence rate estimated between 1 in 4000–1 5000. It may present no apparent symptoms or can manifest as colic related to pancreatitis. The Harlaftis classification system widely used for categorising bladders: type I the split primordial gallbladder, which includes septated, V-shaped and Y-shaped varieties; II accessory type, encompassing H-shaped tubular trabecular types III triplicated type. Prophylactic...
Context.—Myeloid sarcoma of the head and neck region can pose diagnostic challenges because low frequency myeloid potential for tumors almost any lineage to occur in neck. Objective.—To study clinicopathologic immunohistochemical characteristics review differential diagnosis. Design.—We searched cases involving a 24-year period at our institution. The medical records pathology slides were reviewed. Additional stains performed. Results.—We identified 17 patients, age 85 years. Most involved...
The survival advantage of women over men with cutaneous melanoma and the reports accelerated progression during pregnancy have led to studies effect hormones hormone receptors on development melanoma. However, results are inconclusive. We therefore evaluated expression estrogen receptor α, β, androgen in melanomas stage- age-matched pregnant women, nonpregnant by immunohistochemical analysis formalin-fixed, paraffin-embedded archival tissues. In addition, we also assessed mitotic rate using...
Abstract Background Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between other progenitors, as well the assessment of their functions, has long been central focus cell research. In recent years, deep learning emerged powerful tool for image analysis classification/prediction. Methods this study, we explored feasibility employing techniques to differentiate murine HSCs MPPs based solely on...
Abstract Background Adenoid cystic carcinoma (ACC) cells with a high level of ALDH1, known cancer stem cell (CSC) marker, had higher tumorigenic, invasive, and metastatic abilities. We examined the immunohistochemical expression ALDH1 in ACC its correlation survival. Methods Archival paraffin blocks were analyzed. A tissue microarray was constructed analyzed using anti‐ALDH1 monoclonal antibody. Correlations between clinical histological parameters assessed by chi‐square tests. Survival...
Abstract A microRNA (miRNA) nanomedicine PEG-PEI/miR-221/222 was synthesized based on PEGylated polyethylenimine PEG-PEI and used to transfect prostate cancer cells (PC-3) in vitro . Gel retardation assay confirmed the formation of nanomedicine, which zeta potential particle size were determined by dynamic light scattering. Its cytotoxicity analyzed CCK-8 assay-while its transfection efficiency flow cytometry. Cell uptake intracellular distribution nanoparticles evaluated using laser...
Abstract Previous reports have alluded to variability in the aggregation response of normal human platelets neuropeptide arginine vasopressin (AVP). Since it has not been well documented, current studies were undertaken characterize this response. AVP (1‐100 nM) produced a concentration‐dependent Although 100 nM did correlate with age or sex, there was bimodal distribution based on presence absence second wave aggregation. In kinetic studies, apparent km 18.3 ± 5.4 nM. There significant...
Purpose: Chemical Exchange Saturation Transfer (CEST) imaging is an MRI technique enables the detection and of metabolically active compounds in vivo. It has been used to differentiate tumor types metabolic characteristics. Unlike PET/CT,CEST does not use isotopes so it can be on patient repeatedly. This study report preliminary results CEST Head Neck cancer (HNC) patients. Methods: A sequence post‐processing software was developed a 3T clinical scanner. Ten patients with Human papilloma...
A 17-year-old girl presented to her dermatologist's office with a “mole” in genital area. Physical examination showed 0.8 × 0.6-cm tan, slighted elevated lesion on right mons pubis. shave biopsy was performed. Light microscopy revealed nests of melanocytes at the dermoepidermal junction that manifested multinucleated giant cells pale cytoplasms and pigment granules various sizes (Figures 1 2). The melanocyte nuclei were similar size those adjacent keratinocytes had discrete nucleoli. There...
Luman/CREB3 is a transcription factor that member of the cAMP-response-element-binding protein family basic region-leucine zipper factors. This interacts with host cell 1, which also associates herpes simplex virus VP16 to induce virus. Currently, physiological function in reproductive processes remains unclear. In this study, quantitative real-time PCR and immunofluorescence assays were used investigate expression localization Luman mouse oocytes as well early embryonic development. was...
Epithelioid angiosarcoma is a rare vascular neoplasm with an aggressive clinical course and poor prognosis. The cytological diagnosis of epithelioid challenging. Herein, we describe the features in pleural fluid as initial presentation 52-year-old patient 3 years after mastectomy radiation therapy for invasive lobular carcinoma breast. We characteristics body specimens differential diagnosis.