A5100337669- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- CRISPR and Genetic Engineering
- Immune cells in cancer
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- BRCA gene mutations in cancer
- demographic modeling and climate adaptation
- Cancer, Lipids, and Metabolism
- Biomedical Text Mining and Ontologies
- Genomics and Rare Diseases
WinnMed
2013-2025
Amgen (United States)
2025
Sun Yat-sen University
2018-2025
Shanghai Jiao Tong University
2022-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2017-2025
Changzhi Medical College
2025
Mayo Clinic in Florida
2015-2024
Mayo Clinic
2013-2024
Aneuploidy, whole chromosome or arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression proliferation genes. Aneuploidy anti-correlated immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples. Chromosome arm-level alterations show cancer-specific patterns, including loss 3p squamous We applied genome...
<h2>Summary</h2> DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 types. Mutations with accompanying loss heterozygosity were observed in over 1/3 genes, including <i>TP53</i> <i>BRCA1/2</i>. Other prevalent included epigenetic silencing the direct genes <i>EXO5</i>, <i>MGMT</i>, <i>ALKBH3</i> ∼20% samples. Homologous recombination (HRD) was...
Highlights•871 predisposition variants/CNVs discovered in 8% of 10,389 cases 33 cancers•Pan-cancer approach identified shared variants and genes across cancers•33 affecting activating domains oncogenes showed high expression•47 VUSs prioritized using cancer enrichment, LOH, expression other evidenceSummaryWe conducted the largest investigation to date, discovering 853 pathogenic or likely from types. Twenty-one single cross-cancer associations, including novel associations SDHA melanoma...
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique features, clinically significant subtypes, potential therapeutic targets. found 61 somatic copy-number alterations (SCNAs) 46 significantly mutated genes (SMGs). Eleven SCNAs 11 SMGs had not been identified in previous TCGA studies the individual tumor types. functionally estrogen receptor-regulated long non-coding RNAs (lncRNAs)...
Abstract Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human are enriched polymorphisms affect gene expression, some known to associate with expression changes in the brain. Postulating many confer via transcriptional regulatory mechanisms, we analyzed levels brain tissue of subjects AD related diseases. Herein, describe collective datasets...
Molecular classification of high-grade serous ovarian cancer (HGSOC) using transcriptional profiling has proven to be complex and difficult validate across studies. We determined gene expression profiles 174 well-annotated HGSOCs demonstrate prognostic significance the prespecified TCGA Network signatures. Furthermore, we confirm presence four HGSOC subtypes a de novo classification. Survival differed statistically significantly between (log rank, P = .006) was best for immunoreactive-like...
Summary Downregulation of the transcription factor AtMYB103 using transgenic technology results in early tapetal degeneration and pollen aberration during anther development Arabidopsis thaliana . This paper describes functional analysis gene three knock‐out mutants. Two male sterile mutants, ms188‐1 ms188‐2 , were generated by ethyl‐methane sulfonate (EMS) mutagenesis. A map‐based cloning approach was used, ms188 mapped to a 95.8‐kb region on chromosome 5 containing an factor. Sequence...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Highlights•SCCs show chromosome or methylation alterations affecting multiple related genes•These regulate squamous stemness, differentiation, growth, survival, and inflammation•Copy-quiet SCCs have hypermethylated (FANCF, TET1) mutated (CASP8, MAPK-RAS) genes•Potential targets include ΔNp63, WEE1, IAPs, PI3K-mTOR/MAPK, immune responsesSummaryThis integrated, multiplatform PanCancer Atlas study co-mapped identified distinguishing molecular features of cell carcinomas (SCCs) from five sites...
Immune checkpoint blockade (ICB) has revolutionized cancer therapeutics. Desmoplastic malignancies, such as cholangiocarcinoma (CCA), have an abundant tumor immune microenvironment (TIME). However, to date, ICB monotherapy in malignancies been ineffective. Herein, we identify tumor-associated macrophages (TAMs) the primary source of programmed death–ligand 1 (PD-L1) human and murine CCA. In a model CCA, recruited PD-L1+ TAMs facilitated CCA progression. TAM failed decrease progression due...
Abstract DNA polymorphism is the basis to develop molecular markers that are widely used in genetic mapping today. A genome-wide rice (Oryza sativa) database has been constructed this work using genomes of Nipponbare, a cultivar japonica, and 93-11, indica. This contains 1,703,176 single nucleotide polymorphisms (SNPs) 479,406 Insertion/Deletions (InDels), approximately one SNP every 268 bp InDel 953 genome. Both SNPs InDels were experimentally validated. Of 109 randomly selected SNPs, 107...
During mitosis, chromosomes are highly condensed and transcription is silenced globally. One explanation for transcriptional repression the reduced accessibility of factors. To directly test this hypothesis to investigate dynamics mitotic chromatin, we evaluate exchange kinetics several RNA polymerase I factors nucleosome components on chromatin in living cells. We demonstrate that these rapidly off ribosomal DNA clusters varies at different phases mitosis. In addition, component H1c-GFP...
miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), target gene miR-182, plays an important role metastasis cancers. However, it remains unclear what does function and mechanism MTSS1play HCC. expression was tested 86 cases paired HCC normal tissues by real-time PCR relationships between clinicopathological parameters were analyzed. The MTSS1 evaluated immunohistochemistry western blot above its correlation with...
We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1, BRCA2 and RAD51C a large well-annotated patient set. EOC patients for germline deleterious mutations (n = 899), somatic 279) epigenetic alterations 482) these genes using NGS genome-wide methylation arrays. Deleterious were identified 32 (3.6%) 28 (3.1%) 26 (2.9%) RAD51C. Ten somatically sequenced had alterations, six (2.1%) BRCA1 four (1.4%) BRCA2. Fifty two (10.8%)...
Ulcerative colitis (UC) is a major form of chronic inflammation that can frequently progress to colon cancer. Several studies have demonstrated massive infiltration neutrophils and macrophages into the lamina propria submucosa in progression UC-associated carcinogenesis. Macrophages contribute development colitis-associated cancer (CAC). However, role not well understood. To better understand involvement tumor-associated (TANs) regulation CAC, we used mouse CAC model produced by...
Purpose: Recent progress in understanding the molecular biology of epithelial ovarian cancer has not yet translated into individualized treatment for these women or improvements their disease outcome. Gene expression been utilized to identify distinct subtypes, but there have no reports investigating whether subtyping is predictive response bevacizumab cancer.Experimental Design: DASL gene arrays were performed on FFPE tissue from patients enrolled ICON7 trial. Patients stratified four TCGA...