A5100434915- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- interferon and immune responses
- Cancer-related gene regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Pharmaceutical and Antibiotic Environmental Impacts
- Pelvic and Acetabular Injuries
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Recycling and Waste Management Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Photocatalysis Techniques
- Signaling Pathways in Disease
- Corneal surgery and disorders
- Immune cells in cancer
Northeastern University
2016-2025
Sun Yat-sen University
2016-2025
Anhui Agricultural University
2021-2025
Soochow University
2008-2025
Nanjing Medical University
2016-2025
Ministry of Agriculture and Rural Affairs
2019-2025
Xuzhou Medical College
2011-2025
Xuzhou Central Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Capital Medical University
2014-2025
The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. is disrupted by (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias myelodysplasias in humans. Mice lacking CBF alpha 2 protein capable binding DNA die between embryonic days 11.5 12.5 due to hemorrhaging central nervous system (CNS), at nerve/CNS interfaces cranial spinal nerves, somitic/intersomitic regions along presumptive cord. Hemorrhaging preceded symmetric,...
ABSTRACT Cbfa2 (AML1) encodes the DNA-binding subunit of a transcription factor in small family core-binding factors (CBFs). is required for differentiation all definitive hematopoietic cells, but not primitive erythropoiesis. Here we show that expressed progenitor and endothelial cells sites from which these are thought to emerge. Endothelial expressing yolk sac, vitelline umbilical arteries, ventral aspect dorsal aorta aorta/genital ridge/mesonephros (AGM) region. lining aorta, elsewhere...
The CBFβ subunit is the non-DNA-binding of heterodimeric core-binding factor (CBF). associates with DNA-binding CBFα subunits and increases their affinity for DNA. Genes encoding (CBFB) one (CBFA2, otherwise known as AML1) are most frequent targets chromosomal translocations in acute leukemias humans. We others previously demonstrated that homozygous disruption mouse Cbfa2 (AML1) gene results embryonic lethality at midgestation due to hemorrhaging central nervous system blocks fetal liver...
<h3>Importance</h3> The presence of microvascular invasion (MVI) decreases surgical outcomes hepatocellular carcinoma (HCC). An accurate preoperative prediction MVI can help surgeons to better choose procedures, but accuracy is still difficult achieve. <h3>Objective</h3> To develop a nomogram predict before liver resection for hepatitis B virus (HBV)–related HCC within the Milan criteria (solitary nodule ≤5 cm; ≤3 nodules, none >3 and no macrovascular invasion). <h3>Design, Setting,...
The propagation of antibiotic resistance genes (ARGs) represents a global threat to both human health and food security. Assessment ARG reservoirs persistence is therefore critical for devising evaluating strategies mitigate propagation. This study developed novel, internal standard method extract extracellular DNA (eDNA) intracellular (iDNA) from water sediments, applied it determine the partitioning ARGs in Haihe River basin China, which drains an area intensive use. concentration eDNA was...
The early genetic pathway(s) triggering the pathogenesis of coronary artery disease (CAD) and myocardial infarction (MI) remain largely unknown. Here, we describe an autosomal dominant form CAD/MI (adCAD1) that is caused by deletion seven amino acids in transcription factor MEF2A. disrupts nuclear localization MEF2A, reduces MEF2A-mediated activation, abolishes synergistic activation MEF2A GATA-1 through a dominant-negative mechanism. protein demonstrates strong expression endothelium...
We report the whole-genome sequence of common marmoset (Callithrix jacchus). The 2.26-Gb genome a female was assembled using Sanger read data (6×) and shotgun strategy. A first analysis has permitted comparison with genomes apes Old World monkeys identification specific features that might contribute to unique biology this diminutive primate, including genetic changes may influence body size, frequent twinning chimerism. observed positive selection in growth hormone/insulin-like factor genes...
A versatile targeted etching strategy is developed for the large‐scale synthesis of urchin‐like mesoporous TiO 2 hollow spheres (UMTHS) with tunable particle size. Its key feature use a low‐temperature hydrothermal reaction surface‐fluorinated, amorphous, hydrous solid (AHTSS) under protection polyvinylpyrrolidone (PVP) coating. With confinement PVP and water penetration, highly porous AHTSS are selectively etched hollowed by fluoride without destroying their spherical morphology. Meanwhile...
Abstract Coronavirus disease 2019 (COVID-19) was detected in China during the 2019–2020 seasonal influenza epidemic. Non-pharmaceutical interventions (NPIs) and behavioral changes to mitigate COVID-19 could have affected transmission dynamics of other respiratory diseases. By comparing activity through March 29, 2020 with 2011–2019 seasons, we found that outbreaks related NPIs may reduced Southern Northern United States by 79.2% (lower upper bounds: 48.8%–87.2%), 79.4% (44.9%–87.4%) 67.2%...
Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway has been suggested to contribute the pathogenesis cardiovascular diseases. However, whether cGAS-STING involved in development DCM not established. Our study aimed determine role initiation nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3)...