A5028867517- Gut microbiota and health
- Chemotherapy-induced cardiotoxicity and mitigation
- Inflammatory Bowel Disease
- Cardiac Fibrosis and Remodeling
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Electromagnetic Fields and Biological Effects
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Vehicle Dynamics and Control Systems
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Advancements in Battery Materials
- Selenium in Biological Systems
- Clostridium difficile and Clostridium perfringens research
- Phytochemistry and biological activity of medicinal plants
- Barrier Structure and Function Studies
- Frailty in Older Adults
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- Cancer Treatment and Pharmacology
- Ginger and Zingiberaceae research
- Biomarkers in Disease Mechanisms
- Advanced Measurement and Metrology Techniques
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Guangzhou University of Chinese Medicine
2020-2025
Guangzhou Medical University
2024-2025
Beijing Radiation Center
2024-2025
Guangzhou Chest Hospital
2025
State Key Laboratory of Respiratory Disease
2025
Tianjin University of Traditional Chinese Medicine
2024
Kunming Medical University
2024
Zhujiang Hospital
2022-2023
Southern Medical University
2022-2023
Abstract Ulcerative colitis (UC) pathogenesis is largely associated with intestinal epithelial barrier dysfunction. A therapeutic approach to UC involves the repair of damaged barrier. Our study aimed investigate whether aryl hydrocarbon receptor (AhR) mediated effects quercetin ameliorate UC. 3% dextran sulfate sodium was used induce colitic mice, and (25, 50, 100 mg/kg) administered orally for 10 days assess effects. In vitro, Caco‐2 cells were explore effect on tight junction protein...
As one of the ligands aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its mechanism remains obscure. Authentically, can be alleviated by regulating differentiation naïve CD4+ T cells via AhR activation. So, our study planned prove hypothesis that baicalein protected mice against UC balance Th17/Treg Immunofluorescence and western blot results showed could promote...
Shenmai Injection (SMI) has been widely used in the treatment of cardiovascular diseases and can reduce side effects when combined with chemotherapy drugs. However, potential protective mechanism SMI on cardiotoxicity caused by anthracyclines not clear. We network pharmacology methods to collect compound components myocardial injury targets, constructed a 'drug-disease' target interaction relationship diagram, screened core targets predict treating anthracyclines. In addition, rat model...
The treatment of combination drugs in complex diseases has been spotlighted. Ulcerative colitis (UC) is a chronic inflammatory disease that made progress therapy. Baicalin, flavone from Scutellaria baicalensis Georgi. (Lamiaceae), and emodin, an anthraquinone derivative Rhei Radix et Rhizoma. (Polygonaceae), both have reported to possess antiinflammatory activities. Our study investigated whether combined with baicalin emodin had synergistic effect inhibiting inflammation. results showed at...
Abstract Background Non-small cell cancer (NSCLC) patients with concomitant epidermal growth factor receptor (EGFR) and TP53 mutations have a poor prognosis the treatment of tyrosine kinase inhibitors (TKIs), may benefit from combination regimen preferentially. The present study aims to compare benefits EGFR-TKIs its antiangiogenic drugs or chemotherapy in NSCLC harboring EGFR co-mutation real-life setting. Methods This retrospective analysis included 124 advanced having mutations, who...
The reproductive system has been increasingly implicated as a sensitive target of microwave radiation. Oxidative stress plays critical role in radiation -induced damage, though precise mechanisms are obscure. Metformin, widely used antidiabetic drug, emerged an efficient antioxidant against variety oxidative injuries. In the present study, we hypothesized that metformin can function and protect from To test this hypothesis, rats were exposed to 2.856 GHz for 6 weeks simulate real-life...