A5035890476- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Tissue Engineering and Regenerative Medicine
- Microbial Community Ecology and Physiology
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Immune cells in cancer
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- IL-33, ST2, and ILC Pathways
- Bone Tissue Engineering Materials
- Protist diversity and phylogeny
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Genetic and Kidney Cyst Diseases
- Ubiquitin and proteasome pathways
- Bone and Dental Protein Studies
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Wnt/β-catenin signaling in development and cancer
- Electrospun Nanofibers in Biomedical Applications
- Autophagy in Disease and Therapy
- Salivary Gland Disorders and Functions
- Herbal Medicine Research Studies
- Caveolin-1 and cellular processes
Bryan College
2021-2025
Guangzhou University of Chinese Medicine
2022-2024
Texas A&M Health Science Center
2018-2023
Texas A&M University
2021-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Mitchell Institute
2021
Abstract Ulcerative colitis (UC) pathogenesis is largely associated with intestinal epithelial barrier dysfunction. A therapeutic approach to UC involves the repair of damaged barrier. Our study aimed investigate whether aryl hydrocarbon receptor (AhR) mediated effects quercetin ameliorate UC. 3% dextran sulfate sodium was used induce colitic mice, and (25, 50, 100 mg/kg) administered orally for 10 days assess effects. In vitro, Caco‐2 cells were explore effect on tight junction protein...
Abstract Approximately 10% of fractures will not heal without intervention. Current treatments can be marginally effective, costly, and some have adverse effects. A safe manufacturable mimic anabolic bone is the primary goal engineering, but achieving this challenging. Mesenchymal stem cells (MSCs), are excellent candidates for engineering bone, lack reproducibility due to donor source culture methodology. The need a bioactive attachment substrate also hinders progress. Herein, we describe...
Abstract Human mesenchymal stem cells (hMSCs) are effective in treating disorders resulting from an inflammatory or heightened immune response. The hMSCs derived induced pluripotent (ihMSCs) share the characteristics of tissue but lack challenges associated with limited sources and donor variation. To meet expected future demand for ihMSCs, there is a need to develop scalable methods their production at clinical yields while retaining immunomodulatory efficacy. Herein, we describe platform...
Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in destruction, tumor survival and metastases during OS. We examined role of Dkk-1 OS disease progression explored strategies for targeting its activity. enhances by amplifying a non-canonical pathway that upregulates aldehyde dehydrogenase 1A1. Targeting transcription with vivo morpholino (DkkMo) reduced enhanced osteogenic activity vitro. DkkMo as single agent...
Tetrahymena thermophila harbors two functionally and physically distinct nuclei within a shared cytoplasm. During vegetative growth, the "cell cycles" of diploid micronucleus polyploid macronucleus are offset. Micronuclear S phase initiates just before cytokinesis is completed in daughter cells onset macronuclear DNA replication. Mitotic micronuclear division occurs mid-cell cycle, while amitosis coupled to cell division. Here we report first RNA-seq cycle analysis binucleated ciliated...
Radiotherapy of head and neck cancers frequently leads to irreversible hypofunction salivary glands, which severely compromises the quality life is extremely difficult treat. We found recently that gland resident macrophages are sensitive radiation interact with epithelial progenitors endothelial cells through homeostatic paracrine factors. Heterogeneous subpopulations present in other organs distinct functions, whereas functions or transcriptional profiles have not been reported yet. Using...
Abstract Malignant bone disease (MBD) occurs when tumors establish in bone, causing catastrophic tissue damage as a result of accelerated destruction and inhibition repair. The resultant so-called osteolytic lesions (OL) take the form tumor-filled cavities that cause pain, fractures, associated morbidity. Furthermore, OL microenvironment can support survival tumor cells resistance to chemotherapy. Therefore, deeper understanding formation MBD progression is imperative for development future...
Abstract Background Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially doubling 5-year event-free survival if tumour necrosis can be stimulated. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) enhances part through upregulation of aldehyde-dehydrogenase-1A1 which neutralises reactive oxygen species originating from nutritional stress and chemotherapeutic challenge. Methods A vivo morpholino (DkkMo) was employed to...
Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality life and is difficult to treat. Here, we studied effects mechanisms Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid, in preventing irreversible dry mouth caused by radiotherapy. Mouse submandibular (SMGs) were irradiated with or without intra-SMG S1P pretreatment. The saliva flow rate was measured following pilocarpine stimulation. expression...
Background: Psoriasis is a widespread chronic, immune-mediated skin disease with frequent recurrences, and extremely harmful to the physical mental health of patients, causing enormous suffering exerting considerable economic burdens on care system as whole. In more than decade clinical use, optimized formula Yinxieling (PSORI-CM01) has consistently demonstrated its effectiveness for treating psoriasis. However, underlying mechanism remains largely unexplored. Methods: The network...
Inhibiting the death receptor 3 (DR3) signaling pathway in group innate lymphoid cells (ILC3s) presents a promising approach for promoting mucosal repair individuals with ulcerative colitis (UC). Paeoniflorin, prominent component of Paeonia lactiflora Pall., has demonstrated ability to restore barrier function UC mice, but precise mechanism remains unclear. In this study, we aimed delve into whether paeoniflorin may promote intestinal chronic by inhibiting DR3 ILC3s. C57BL/6 mice were...
ABSTRACT As a prototypic ciliated protozoan, Tetrahymena thermophila harbors two functionally and physically distinct nuclei within shared cytoplasm. During vegetative growth, the ‘cell cycles’ of diploid germline micronucleus polyploid somatic macronucleus are offset. Micronuclear S phase initiates just before cell division is completed in daughter cells prior to onset macronuclear phase. Whereas mitotic micronuclear occurs mid-cell cycle, amitotic immediately precedes cytokinesis. Here we...
Abstract Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially doubling 5-year event-free survival if tumor necrosis can be stimulated, but long-term treatment results detriment to health and quality of life. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) enhances part through upregulation aldehyde-dehydrogenase-1A1 (ALDH1A1) which neutralizes reactive oxygen species from nutritional stress chemotherapeutic challenge....
Abstract Osteo-enhanced human mesenchymal stem cells (OEhMSCs) secrete an osteogenic cell matrix (OCM) that mimics the composition of anabolic bone tissue and strongly enhances OEhMSC retention subsequent repair in vivo . Here we demonstrate a system for rapid production gelatin methacrylate microcarriers coated with decellularized OCM (OCM-GelMA) to serve as injectable graft material high potential comparable clinically utilized gold standard, morphogenic protein 2 (BMP-2). OEhMSCs seeded...