A5100388495- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Bone health and treatments
- Lipid metabolism and disorders
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Diabetes Management and Education
- Nutrition and Health in Aging
- Traditional Chinese Medicine Studies
- Migraine and Headache Studies
- Bone Metabolism and Diseases
- Cancer, Lipids, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
Chinese PLA General Hospital
2015-2025
Tianjin University of Traditional Chinese Medicine
2025
Inner Mongolia Medical University
2020-2025
Beijing Normal University - Hong Kong Baptist University United International College
2025
Center for Life Sciences
2024
Tsinghua University
2024
Chinese People's Liberation Army
2009-2023
First Affiliated Hospital of Wannan Medical College
2023
Institute of Endocrinology
2023
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2017-2023
Because islet transplantation has become a promising treatment option for patients with type 1 diabetes, noninvasive imaging method is greatly needed to monitor these islets over time. Here, we developed an <sup>18</sup>F-labeled exendin-4 in high specific activity by targeting the glucagonlike peptide-1 receptor (GLP-1R). <b>Methods:</b> Tetrazine ligation was used radiolabel <sup>18</sup>F. The binding of <sup>19/18</sup>F-tetrazine <i>trans</i>-cyclooctene...
Despite treatment with agents that enhance β-cell function and insulin action, reduction in mass is relentless patients resistance type 2 diabetes mellitus. Insulin characterized by impaired signaling through the insulin/insulin receptor/insulin receptor substrate/PI-3K/Akt pathway, leading to elevation of negatively regulated substrates such as glycogen synthase kinase-3β (Gsk-3β). When elevated, this enzyme has antiproliferative proapoptotic properties. In these studies, we designed...
Opioid use has been reported to be associated with increased fracture risks. In a nested case-control study using the United Kingdom-based General Practice Research Database, we tested hypotheses that risk was 1) an elevated of falls caused by acute central nervous system effects opioids including sedation and dizziness, 2) osteoporosis chronic opioid-induced hypogonadism. Among cohort adults aged 18-80 years without cancer who received ≥1 opioid prescription during 1990-2008, selected cases...
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for vivo islet imaging. Because native GLP-1 degraded rapidly by dipeptidyl peptidase-IV (DPP-IV), more stable agonist of such as Exendin-4 preferred imaging agent. In this study, DO3A-VS-Cys(40)-Exendin-4 was prepared through the conjugation DO3A-VS with Cys(40)-Exendin-4. The vitro binding affinity evaluated INS-1...
To explore the values of neutrophil to lymphocyte ratio (NLR), platelet (PLR), albumin (NAR), prognostic nutritional index (PNI), systemic immune inflammatory (SII) and red cell distribution width (RA) for evaluating risk 30-day mortality ischemic stroke or hemorrhagic patients.In this cohort study, data 1,601 patients diagnosed with were extracted from Medical Information Mart Intensive Care III (MIMIC-III) database. Among them, 908 693 patients. Demographic clinical variables collected....
Abstract Background Astragalus polysaccharides (APS) have been verified to antioxidative and antiaging activities in the mouse liver brain. However, effect of APS on aortic endothelial senescence old rats its underlying mechanism are currently unclear. Here, we aimed elucidate effects rat oxidative stress vitro vivo investigate potential molecular targets. Methods Twenty-month-old natural aging male were treated with (200 mg/kg, 400 800 mg/kg daily) for 3 months. Serum parameters tested...
Background The triglyceride glucose index (TyG index) has been regarded as a reliable surrogate marker of insulin resistance and an independent predictor diabetes. However, few studies have reported the association between TyG diabetes in elderly population. Accordingly, this study aimed to investigate progression Chinese. Methods Baseline medical history, fasting plasma (FPG), levels during oral tolerance test (OGTT) after 1-hour (1h-PG) 2-hour (2h-PG), (TG) were obtained from cohort 862...
Berberine is a natural plant alkaloid isolated from diverse range of genera, it obtains anti-inflammatory, anti-obesity, and hepatoprotective properties, promising agent for non-alcoholic steatohepatitis (NASH). Farnesoid X receptor (FXR) bile acid drug target NASH, however, the underlying mechanisms berberine on regulating FXR are still unknown. In present study, we feed mice with 12-week high-fat diet interval dextran sulfate sodium (0.5% in drinking water) to induce treat (100 mg/kg per...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver-related morbidity and mortality. Though high fructose intake acknowledged as a metabolic hazard, its role in etiology MASLD requires further clarification. Here, we demonstrated that dietary drives development promotes progression mice, identified
Recent evidence suggests that experimental induction of hepatocytes into pancreatic cells provides new cell transplantation therapy prospects for type 1 diabetes mellitus. Stepwise differentiation from rat liver epithelial stem-like WB-F344 (WB cells) functional insulin-secreting will identify key steps in β-cell development and may yet prove useful diabetic patients. An essential step this protocol was the generation precursor express Pdx1 based on by a combination 5-aza-2′-deoxycytidine,...
To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia NGT (HINS), impaired (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM).5 NGT, 25 HINS, IGT, T2DM participated this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed all of them to IR levels. relative factors influencing were evaluated. simple sensitivity indices calculated, correlation between each index M value analyzed.The values...
Oxidized low-density lipoprotein (ox-LDL) uptake by monocytes/macrophages plays a pivotal role in atherogenesis. This study was designed to examine the effect of glucagon-like peptide-1 (GLP-1) agonists on ox-LDL macrophages. Human primary were incubated with native GLP-1 (nGLP-1) or agonist liraglutide evaluate their and expression scavenger receptors (SRs), such as SR-A, CD36, lectin-like SR-1, this process. Our showed decrease CD36 macrophages treated nGLP-1 liraglutide. However, did not...
Type 2 diabetes [T2D] and thyroid dysfunction [TD] often co-occur, have overlapping pathologies, their risk increases with age. Since 1995, universal salt iodization has been implemented in China to prevent disorders caused by iodine deficiency. However, after two decades of implementation iodization, the prevalence TD elderly Chinese patients T2D is not well described may underestimated. We conducted a questionnaire-based survey across 24 endocrinology centers between December 2015 July...
Berberine compounds (BC), consisting of berberine (BBR), oryzanol and vitamin B6, have been used to treat diabetes hyperlipidemia in recent years, but the potential mechanisms under effects not well determined. In this study, we evaluated effect BC db/db mice, found that treatment reversed increased levels fasting glucose hemoglobin A1c which was superior BBR treatment. Fecal 16S rRNA gene sequencing indicated relative abundance microbiomes Bacteroidaceae Clostridiaceae, may promote...
Salvia-Nelumbinis naturalis (SNN) formula is a traditional Chinese medicine prescription, and has been confirmed to be effective in treating non-alcoholic steatohepatitis (NASH), but the underlying mechanisms are still unknown. Here we showed that 4-week SNN administration alleviated methionine-choline-deficiency (MCD) diet-induced hepatic steatosis inflammation as well serum levels of alanine transaminase (ALT) increase C57BL/6 mice. Fecal 16S rDNA sequencing indicated altered structure gut...