A5082212717- COVID-19 Clinical Research Studies
- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Pancreatic function and diabetes
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- ATP Synthase and ATPases Research
- Obstructive Sleep Apnea Research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Kawasaki Disease and Coronary Complications
- Regulation of Appetite and Obesity
- Immune cells in cancer
- Sarcoidosis and Beryllium Toxicity Research
- Parkinson's Disease Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Healthcare professionals’ stress and burnout
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chinese PLA General Hospital
2011-2025
National Clinical Research
2020-2021
Chinese People's Liberation Army
2018-2020
Hainan Branch of People's Liberation Army General Hospital
2019
Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported patients infected with virus. In this study, we aimed to further investigate prevalence and outcomes COVID-19 symptoms.In descriptive, cross-sectional, multicenter enrolled confirmed who presented 3 hospitals from January 18, 2020, February 28, 2020. All were by real-time polymerase chain reaction analyzed for clinical characteristics, laboratory data,...
The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. risk factors for were attributed to advanced age and comorbidities but have not been accurately defined.
The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory syndrome 2 (SARS-CoV-2) erupted in Hubei Province of China December and has become a pandemic. Severe COVID-19 patients who suffer from distress (ARDS) multi-organ dysfunction have high mortality. Several studies shown that this is closely related to the cytokine release (CRS), often loosely referred as storm. IL-6 one key factors its level positively correlated with severity disease. molecular mechanisms for CRS...
Receptor‐interacting protein 3‐ (RIPK3‐) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In present study, we showed that RIPK3 expression was upregulated tissue MI mouse model by coronary artery ligation, as well cardiomyocytes following hypoxic injury vitro . The increase of found to be accompanied severe remodelling, dysfunction, and higher mortality. Elevated...
The presence of endotoxemia is strongly linked to the development endothelial dysfunction and disruption myocardial microvascular reactivity. These factors play a crucial role in progression endotoxemic cardiomyopathy. Sepsis-related multiorgan damage involves participation catalytic subunit DNA-dependent protein kinase (DNA-PKcs). However, whether DNA-PKcs contributes during remains unclear. Hence, we conducted experiments mice subjected lipopolysaccharide (LPS)-induced cardiomyopathy, as...
Idiopathic pulmonary fibrosis (IPF) is an irreversible interstitial lung disease with a poor prognosis. However, there are currently few drugs available for its treatment. Nintedanib clinically effective but associated gastrointestinal adverse effects and weight loss. Due to drug intolerance, the overall outcomes of nintedanib therapy substantially compromised in quite patients. In present study, we synthesized nintedanib-loaded biomimetic liposomes (Nin-lipo) improve antifibrotic efficacy...
The objective of the study was to systematically evaluate and perform a meta-analysis on adherence high-flow nasal cannula (HFNC) humidified oxygen therapy its influencing factors in elderly patients with stable chronic obstructive pulmonary disease (COPD). Relevant literature HFNC COPD retrieved from PubMed, EMbase, Web Science, Cochrane Library databases. Cross-sectional studies, case-control cohort studies were included. Screening quality assessment conducted using Endnote X9 software....
BackgroundSome cardiovascular risk factors have been confirmed to be positively correlated with arterial stiffness. However, it is unclear whether HDL-C, a well-established anti-risk factor, has an independent association The aim of this study was evaluate the relationship between HDL-C levels and stiffness possible role high-sensitivity C-reactive protein (hs-CRP) in potential correlation apparently healthy adults undergoing general health examination China. Materials MethodsThis...
Large tumor suppressor kinase 2 (Lats2) is a member of the Hippo pathway, critical regulator organ size. Since Lats2 activity may trigger mitochondrial dysfunction, key pathogenic factor in acute myocardial infarction (AMI), this study sought to investigate whether deletion confers cardioprotection AMI. AMI was induced cardiomyocyte-specific knockout (Lats2Cko) and control (Lats2flox) mice. Twenty-eight days after surgery, performance homeostasis were impaired Lats2floxmice. In contrast,...
Abstract Frontline healthcare nurses devoted themselves to deal with the outbreak of COVID-19, saving many lives. However, they are under incredible unknown psychological pressures a considerable risk infection. In this study, self-administered questionnaire was used survey 593 frontline in Wuhan City and non-Hubei provinces for responses from March 1 10, 2020. Compared outside Hubei Province, those working were more likely feel physically mentally exhausted. Their probable depression...
Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of on injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice. Edaravone was injected into mice 30 min before 4 h after GalN/LPS injection. The survival rate determined within first 24 h. Animals were killed 8 injection, biochemically histologically assessed. Hepatocyte apoptosis measured TUNEL staining; proinflammatory cytokines [tumor necrosis factor-α...
Receptor-interacting protein 3 (Ripk3) plays a crucial part in acute lung injury (ALI) by regulating inflammation-induced endothelial damage the tissue. The precise mechanisms through which Ripk3 contributes to ALI still remain uncertain. In current research, we employed Ripk3-deficient (Ripk3
B-cell receptor-associated protein 31 (BCAP31) has protective effects against alveolar epithelial type II cells (AECII) damage by inhibiting mitochondrial injury in acute lung (ALI) induced lipopolysaccharide (LPS), whereas the precise mechanism is still unclear. It known that PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy can remove damaged mitochondria selectively, which may be involved BCAP31 protection injury.
Hypersensitivity pneumonitis (HP) is a common type among all the interstitial lung diseases, and transbronchial cryobiopsy an alternative diagnostic technique for diseases. In this study, we describe clinical pathological features of fibrotic hypersensitivity diagnosed with (TBLC).A total 46 diffused parenchyma disease (DPLD) patients received TBLC were included in study. Medical records including medical history spirometry examinations, 6-min walk test (6MWT) results, high resolution...
Mitophagy, known as the main mechanism of mitochondrial quality control, determines pathophysiology septic cardiomyopathy, although precise regulatory mechanisms remain elusive. Data from present study suggested that receptor-interacting protein kinase 3 (RIPK3) expression could be enhanced in response to lipopolysaccharide (LPS) challenge. Upregulated RIPK3 was accompanied by severe cardiac injury and dysfunction. Further examination revealed elevated subsequently inhibited Yes-associated...