Jurandyr Moreira de Andrade
A5090278499- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Women's cancer prevention and management
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Cervical Cancer and HPV Research
- Gestational Trophoblastic Disease Studies
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Uterine Myomas and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Infrared Thermography in Medicine
Universidade Brasil
1997-2024
Universidade de Ribeirão Preto
2007-2024
Universidade de São Paulo
2015-2024
Universidade Católica de Brasília
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008-2023
Hospital Universitário da Universidade de São Paulo
2021
IQVIA (France)
2021
Clinics Hospital of Ribeirão Preto
2007-2020
Keck Hospital of USC
2017
Centro Paulista de Investigação Clinica
2012
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The aggressiveness of invasive ductal carcinoma (IDC) the breast is associated with increased IL17 levels. Studying role in tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocytes produced elevated levels IL17, whereas neutralization inhibited growth and prevented migration neutrophils cells to secondary disease sites. Tumorigenic promote progression, producing CXCL1, MMP9, VEGF, TNFα, their depletion suppressed growth. IL17A also induced IL6 CCL20 production...
Breast cancer is a leading cause of neoplasia‐associated death in women worldwide. Regulatory T (Treg) and Th17 cells are enriched within some tumors, but the role these play invasive ductal carcinoma (IDC) breast unknown. We show that CD25 + CD4 from PBMCs tumor express high levels Foxp3, GITR, CTLA‐4, CD103, indicating tumor‐infiltrating Treg functional possibly recruited by CCL22. Additionally, we observed upregulation Th17‐related molecules (IL‐17A, RORC, CCR6) IL‐17A produced CD8...
Abstract We aimed to validate the prognostic association of p16 expression in ovarian high‐grade serous carcinomas (HGSC) and explore it other carcinoma histotypes. protein was assessed by clinical‐grade immunohistochemistry 6525 including 4334 HGSC using tissue microarrays from 24 studies participating Ovarian Tumor Tissue Analysis consortium. patterns were interpreted as abnormal (either overexpression referred block or absence) normal (heterogeneous). CDKN2A (which encodes p16) mRNA also...
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of patients do not benefit from this clinical treatment and, predictive factors response were defined yet. This study was designed to evaluate importance biological markers predict and prognosis stage II III cancer treated with taxane anthracycline combination as neoadjuvant setting. Sixty received preoperative docetaxel (75 mg/m2) epirubicin (50 i.v. infusion D1 every 3 weeks...
Invasive lobular carcinoma (ILC) and neoplasia (LN) are two distinct conditions that still pose challenges regarding to their classification, diagnosis management. Although they share similar cellular characteristics, such as discohesive neoplastic cells absence of e-cadherin staining, represent completely different conditions. LN encompasses atypical hyperplasia (ALH) in situ (LCIS), which currently considered risk factors non-obligatory precursors breast neoplasia. These lesions diagnosed...
The diagnosis and treatment of breast cancer may negatively affect the quality life (QOL) women.The aim this study is to assess QOL in women with who were treated or without chemotherapy identify factors associated improved worsening these women.This cross-sectional enrolled 112 (CTX group, 85 [75.9%] women) (non-CTX 27 [24.1%] for cancer. Short-Form Health Survey (SF-36) assessed Hospital Anxiety Depression scale anxiety depression.The overall mean SF-36 score was below 50 all domains....
Breast cancer is the most common in women worldwide and metastatic dissemination principal factor related to death by this disease. stem cells (bCSC) are thought be responsible for metastasis chemoresistance. In study, based on whole transcriptome analysis from putative bCSC reverse engineering of transcription control networks, we identified two networks associated with phenotype. One controlled SNAI2, TWIST1, BNC2, PRRX1 TBX5 drives a mesenchymal or CSC-like The second network SCML4,...
O uso de plantas medicinais é uma prática ancestral que vem ganhando espaço na saúde pública brasileira nos últimos anos, especialmente com a implementação da Política Nacional Práticas Integrativas e Complementares (PNPIC) no Sistema Único Saúde (SUS). Esta revisão narrativa tem como objetivo analisar literatura recente sobre o atenção básica, destacando seus benefícios, desafios perspectivas. Foram consultadas bases SciELO, BVS PubMed, priorizando estudos publicados entre 2015 2024. Os...
The role of immune system in the pathogenesis and progression breast cancer is a subject controversy, this stimulated us to investigate association immunophenotype tumor-infiltrating lymphocytes early with spread tumor cells axillary lymph nodes.Tumor samples from 23 patients Department Gynecology Obstetrics Ribeirão Preto Medical School (USP) were obtained at time biopsy submitted an enzyme-digestion procedure for extraction lymphocytes. extracted analyzed by dual-color flow cytometry...
Axillary masses are uncommon alterations when detected as an isolated finding. We evaluated 31 patients with axillary masses. Patients of the breasts or upper limbs Ipsilateral chest lesions were excluded from study. Nine had occult breast cancer, 5 them in contralateral breast. Seven metastatic lymph nodes non-ductal origin, and 1 carcinoma apocrine cells metastasis to axilla. Four benign lymphadenopathy which disappeared spontaneously, 4 others ruptured infundibular follicular cyst,...
Oral health can affect a patient's general and quality of life. Given the increase in breast cancer survival rates, investigations factors influencing life survivors have gained importance. Therefore, objective our study was to characterize oral postmenopausal survivors.We conducted matched case-control study. Forty-eight women who survived (age 62.1±9.1 years) 48 healthy controls 61.8±8.6 were included. For each case control, complete evaluation chart completed.The prevalence chronic...
Recently it has been demonstrated that constitutively activated signal transducer and activator of transcription 1 (STAT1) gene expression may act as a biomarker ovarian cancer chemotherapy response. In this study, our objective was to validate the use STAT1 immunohistochemistry prognostic for disease outcome using cohort derived from Latin America.We evaluated Brazilian high-grade serous cancer, comprising 65 patients with data covering more than 5 years determine predictive value levels....
Breast cancer incidence has been substantially increasing in developing countries the last decades.[1] In Brazil, total number of new diagnosed cases reaches 60,000 a year, resulting an rate 60/100,000 women per year.[2] Despite high incidence, breast is described as relatively good prognosis cancer. The worldwide incidence/mortality 3.3.[3] However, this ratio varies within different populations with evident decrease when comparing to developed ones. impact scenario may be attributed late...
Breast cancer screening is not recommended for young women (< 40 years old); therefore, those diagnosed are more likely to have advanced and metastatic disease, reducing treatment outcomes. This study aimed investigate breast epidemiology among in Brazil.Data from three publicly available databases a cohort university hospital Brazil were analyzed retrospective study. Descriptive statistics was performed on disease prevalence stage distribution across age groups. Incidence estimated using...
Aims and background There is an enhanced immune response in patients with breast cancer after the use of chemotherapy. The objective this study was therefore to investigate alterations number peripheral lymphocytes neoadjuvant chemotherapy (NC) relationship prognosis. Methods Thirty women were analyzed. Their UICC staging IIb (only T3N0 included) III (N3 not included). Sample analysis performed using flow cytometry before first cycle 18 21 days last NC. lymphocyte subsets studied were: T...
ObjectiveTo evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, overall survival.Patients MethodsWe conducted centralized immunohistochemical staining, semi-quantitative scoring, survival analysis 5263 patients participating the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, December 31, 2014, including 2865...