A5005468871- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Virus-based gene therapy research
- interferon and immune responses
- Cannabis and Cannabinoid Research
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Uterine Myomas and Treatments
- Urinary and Genital Oncology Studies
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Viral gastroenteritis research and epidemiology
- IL-33, ST2, and ILC Pathways
- Religion, Spirituality, and Psychology
- Eosinophilic Esophagitis
Queen's University
2015-2024
McGill University
2024
Siemens (Canada)
2023
Kingston Health Sciences Centre
2018-2022
Kingston General Hospital
2012-2022
Queens University
2022
The King's University
2019-2020
Cancer Genetics (United States)
2019
American Society for Reproductive Medicine
2015
American Society for Reproductive Immunology
2015
The epithelial to mesenchymal transition (EMT) is a molecular process through which an cell undergoes transdifferentiation into phenotype. role of EMT in embryogenesis well-characterized and increasing evidence suggests that elements the may be important other processes, including metastasis drug resistance various different cancers.Agilent 4 × 44 K whole human genome arrays selected reaction monitoring mass spectrometry were used investigate mRNA protein expression A2780 cisplatin sensitive...
The ability of tumor cells to avoid immune destruction (immune escape) as well their acquired resistance anti-cancer drugs constitute important barriers the successful management cancer. Interaction between Programmed Death Ligand 1 (PD-L1) on surface with Death-1 (PD-1) receptor cytotoxic T lymphocytes leads inactivation these effectors and, consequently, escape. Here we show that PD-1/PD-L1 axis also cell conventional chemotherapeutic agents. Using a panel PD-L1-expressing human and mouse...
An important aspect of malignant progression is the acquired ability tumor cells to avoid recognition and destruction by immune system (immune escape). Clinical cancer also associated with development hypoxia, which mechanistically linked acquisition phenotypes in cells. Despite well-established role hypoxia cell invasion metastasis, resistance therapy, relatively few studies have examined contribution escape. Accumulating evidence reveals that can impair anticancer immunity altering...
Abstract Exosomes and microvesicles are extracellular vesicles released from cells can contain lipids, miRNAs proteins that affect at distant sites. Recently, containing miRNA have been implicated in uterine microenvironment of pigs, a species with unique epitheliochorial (non-invasive) placentation. Here we report novel role conceptus-derived exosomes/microvesicles (hereafter referred to as vesicles; EVs) embryo-endometrial cross-talk. We also demonstrate the stimulatory effects EVs...
High-grade serous carcinoma (HGSC) of the ovary is predominantly diagnosed at late stages and primarily treated with debulking surgery followed by platinum/taxane-based chemotherapy. Although certain patients benefit significantly from currently used chemotherapy, there are who either do not respond or have an inadequate duration response. We previously showed that tumours chemoresistant immunosuppressed pre-existing tumour immune microenvironment decreased expression Type I Interferon...
Endometriosis is a debilitating gynecological disease characterized by the extrauterine presence of, endometrial-like tissues located on peritoneal membrane and organs of pelvic cavity. Notably, dysfunctional immune activation in women with endometriosis could also contribute to development disease. In particular, alternatively activated (M2) macrophages are shown aid lesion promoting remodeling extracellular matrix neovascularization lesions. However, stimuli responsible for polarizing M2...
Molecular subtyping of urothelial cancer (UC) has significantly advanced the understanding bladder tumor heterogeneity and development prognostic predictive biomarkers. Evolving evidence across cancers strongly suggests that immunoediting a profound impact on behaviour cells their adaptation to co-evolving microenvironment response treatment. In alignment with these concepts, recent immune checkpoint blockade (ICB) therapies in UC have demonstrated potential mutations DNA damage repair (DDR)...
With multifactorial etiologies, combined with disease heterogeneity and a lack of suitable diagnostic markers therapy, endometriosis remains major reproductive health challenge. Extracellular vesicles (EVs) have emerged as contributors progression in several conditions, including variety cancers; however, their role pathophysiology has remained elusive. Using next-generation sequencing EVs obtained from patient tissues plasma samples compared controls, we documented that carry unique...
Abstract Background Resistance to platinum-based chemotherapy remains a major impediment in the treatment of serous epithelial ovarian cancer. The objective this study was use gene expression profiling delineate deregulated pathways and biomarkers associated with development intrinsic resistance upon exposure standard first-line therapy for Methods cohort comprised 28 patients divided into two groups based on their varying sensitivity using progression free survival (PFS) as surrogate...
Abstract Endometriosis is a debilitating condition that categorized by the abnormal growth of endometrial tissue outside uterus. Although pathogenesis this disease remains unknown, it well established endometriosis patients exhibit immune dysfunction. Interleukin (IL)-33 danger signal critical regulator chronic inflammation. plasma and peritoneal fluid levels IL-33 have been associated with deep infiltrating endometriosis, its contribution to pathophysiology unknown. We investigated role in...
Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and surrounding microenvironment (TME). Loss of PTEN suppressor gene is observed in 20% to 30% prostate cancers (PCa) when first detected rate increases with PCa progression advanced disease. Recent findings implicate a role for cellular type I interferon response immunosuppression PCa. However, way inactivation alters antitumor immune poorly understood.To investigate...
Endometriosis is a chronic inflammatory, gynecological disease characterized by the presence of endometrial-like tissue lesions outside uterus. Neutrophils are elevated in systemic circulation and peritoneal fluid endometriosis patients; however, whether how neutrophils contribute to pathophysiology remain poorly understood. With emerging roles for sterile inflammatory conditions, we sought provide in-depth characterization neutrophil involvement endometriosis. We demonstrate that reside...
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms such angiogenesis, fibrosis, and pain. The influence on mast cell function has been recognized a potential factor driving pathophysiology number conditions. However, precise information lacking cross talk between endocrine immune factors within...
Osteosarcoma is the most common malignancy of bone, and occurs frequently in children adolescents. Currently, reliable technique for determining a patients' prognosis measurement histopathologic tumor necrosis following pre-operative neo-adjuvant chemotherapy. Unfavourable indicated by less than 90% estimated tumor. Neither genetic testing nor molecular biomarkers diagnosis have been described osteosarcomas. We used novel nanoString mRNA digital expression analysis system to analyse gene 32...
Chemotherapy resistance is a major determinant of poor overall survival rates in high-grade serous ovarian cancer (HGSC). We have previously shown that gene expression alterations affecting the NF-κB pathway characterise chemotherapy HGSC, suggesting regulation an immune response may be associated with this phenotype.Given intrinsic drug pre-exists and governed by both tumour host factors, current study was performed to examine cross-talk between inflammatory microenvironment cells, their...
High-grade serous ovarian carcinoma (HGSC) accounts for 70% of all epithelial cancers but clinical management is challenged by a lack accurate prognostic and predictive biomarkers chemotherapy response. This study evaluated the role Signal Transducer Activator Transcription 1 (STAT1) as an independent biomarker its correlation with intratumoural CD8+ T cells in second validation study. Tumour STAT1 expression cell infiltration were assessed immunohistochemistry multicentre conducted on 734...