A5066589957- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Reproductive Physiology in Livestock
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Ovarian cancer diagnosis and treatment
- COVID-19 Impact on Reproduction
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Ruminant Nutrition and Digestive Physiology
- Extracellular vesicles in disease
- Immune cells in cancer
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Renal and related cancers
- Animal Nutrition and Physiology
- Preterm Birth and Chorioamnionitis
- Livestock Management and Performance Improvement
- Tryptophan and brain disorders
- Nuts composition and effects
- Cytokine Signaling Pathways and Interactions
- Genetic and phenotypic traits in livestock
Food and Drug Administration
2024
National Center for Toxicological Research
2024
United States Food and Drug Administration
2024
Cornell University
2019-2023
Queen's University
2013-2022
Louisiana State University
2021
Nova Scotia Department of Agriculture
2010
National Dairy Research Institute
2007
Abstract Exosomes and microvesicles are extracellular vesicles released from cells can contain lipids, miRNAs proteins that affect at distant sites. Recently, containing miRNA have been implicated in uterine microenvironment of pigs, a species with unique epitheliochorial (non-invasive) placentation. Here we report novel role conceptus-derived exosomes/microvesicles (hereafter referred to as vesicles; EVs) embryo-endometrial cross-talk. We also demonstrate the stimulatory effects EVs...
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms such angiogenesis, fibrosis, and pain. The influence on mast cell function has been recognized a potential factor driving pathophysiology number conditions. However, precise information lacking cross talk between endocrine immune factors within...
Placental growth factor (PGF) is expressed in the developing mouse brain and contributes to vascularization vessel patterning.PGF dynamically fetal brain, particularly forebrain, essential for normal cerebrovascular development.PGF rises maternal plasma over human pregnancy but low many women with acute onset hypertensive syndrome, pre-eclampsia (PE). Little known about expression of PGF fetus during PE. Pgf (-/-) mice appear recently cerebral vascular defects were documented adult...
Chemotherapy resistance is a major determinant of poor overall survival rates in high-grade serous ovarian cancer (HGSC). We have previously shown that gene expression alterations affecting the NF-κB pathway characterise chemotherapy HGSC, suggesting regulation an immune response may be associated with this phenotype.Given intrinsic drug pre-exists and governed by both tumour host factors, current study was performed to examine cross-talk between inflammatory microenvironment cells, their...
MicroRNAs (miRNAs) post-transcriptionally regulate a vast network of genes by inhibiting mRNA translation. Aberrant miRNA expression profiles have been implicated in pathologies and physiological processes including pregnancy angiogenesis. Using our established model implantation failure spontaneous fetal loss pigs (Sus scrofa), 236 miRNAs were profiled compared between 1) non-pregnant pregnant endometrium, 2) maternal tissues, 3) viable growth-arrested conceptus attachment sites microarray...
ABSTRACT Humans and mice have cyclical regeneration of the endometrial epithelium. It is expected that such ensured by tissue stem cells, but their location hierarchy remain debatable. A number recent studies suggested presence cells in mouse At same time, it has been reported this can be regenerated stromal/mesenchymal or bone marrow cell origin. Here, we describe a single-cell transcriptomic atlas main types uterus epithelial subset transcriptome evaluate contribution expressing...
Endometriosis, a major reproductive pathology affecting 8-10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved in including: tumor necrosis factor alpha (TNF-α), granulocyte macrophage colony stimulating (GM-CSF), interleukin 6 (IL-6) among others, stabilize destabilize them, respectively. The aim this study was examine protein (RNABP) HuR/TTP axis...
Abstract Many high-grade serous carcinomas (HGSCs) likely originate in the distal region of Fallopian tube’s epithelium (TE) before metastasizing to ovary. Unfortunately, molecular mechanisms promoting malignancy TE are obfuscated, largely due limited primary human gene expression data. Here we report an depth bioinformatic characterization 34 mRNA-seq samples. These samples were prepared from proximal and regions 12 normal tubes. Samples segregated based on their aldehyde dehydrogenase...
To evaluate the expression of tristetraprolin family and their selected targets during porcine pregnancy. Using qPCR Western blot, mRNA protein levels were compared between endometrium chorioallantoic membrane (CAM) associated with healthy impaired conceptuses at gestation day (gd) 20 gd50, respectively. Immunohistochemistry was performed to determine localization TIS11 members gd20 50. Multiple significant differences (P < 0.05) in transcripts observed aforementioned comparisons. GM-CSF...
Abstract Fatty acids and phytoestrogens have been linked to short- long-term alterations of reproductive performance in sheep. Red clover (RC) contains phytoestrogens, which reduced However, rams fed RC increased omega-3 polyunsaturated fatty (n-3 PUFAs) conjugated linoleic acid (CLA). These beneficial may improve rams. Fish oils (FO) contain significant amounts n-3 PUFA these performance. This study aimed determine the effects pasture supplementation on ram lamb seminiferous tubule...