A5081271801- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cannabis and Cannabinoid Research
- Uterine Myomas and Treatments
- Religion, Spirituality, and Psychology
- Dietary Effects on Health
- IL-33, ST2, and ILC Pathways
- Menstrual Health and Disorders
- Extracellular vesicles in disease
- Dermatology and Skin Diseases
- Endometrial and Cervical Cancer Treatments
- Diet, Metabolism, and Disease
- Eosinophilic Esophagitis
- COVID-19 Impact on Reproduction
- Mast cells and histamine
- Urticaria and Related Conditions
Queen's University
2019-2025
McGill University
2024
The King's University
2021
With multifactorial etiologies, combined with disease heterogeneity and a lack of suitable diagnostic markers therapy, endometriosis remains major reproductive health challenge. Extracellular vesicles (EVs) have emerged as contributors progression in several conditions, including variety cancers; however, their role pathophysiology has remained elusive. Using next-generation sequencing EVs obtained from patient tissues plasma samples compared controls, we documented that carry unique...
Endometriosis is an estrogen dominant, chronic inflammatory disease characterized by the growth of endometrial-like tissue outside uterus. The most common symptoms experienced patients include manifestations pelvic pain- such as pain with urination, menstruation, or defecation, and infertility. Alterations to Leukemia Inhibitory Factor (LIF), a cytokine produced luminal glandular epithelium endometrium that imperative for successful pregnancy, have been postulated contribute Conditions...
Endometriosis is a chronic inflammatory, gynecological disease characterized by the presence of endometrial-like tissue lesions outside uterus. Neutrophils are elevated in systemic circulation and peritoneal fluid endometriosis patients; however, whether how neutrophils contribute to pathophysiology remain poorly understood. With emerging roles for sterile inflammatory conditions, we sought provide in-depth characterization neutrophil involvement endometriosis. We demonstrate that reside...
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms such angiogenesis, fibrosis, and pain. The influence on mast cell function has been recognized a potential factor driving pathophysiology number conditions. However, precise information lacking cross talk between endocrine immune factors within...
Chronic inflammation and localized alterations in immune cell function are suspected to contribute the progression of endometriosis its associated symptoms. In particular, alarmin IL-33 is elevated plasma, peritoneal fluid, endometriotic lesions from patients with endometriosis; however, exact role pathophysiology not well understood. this study, we demonstrate, both humans a murine model, that contributes expansion group 2 innate lymphoid cells (ILC2s), IL-33-induced ILC2 modulates lesion...
Abstract Endometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting pelvic pain and infertility. IL-23 key contributor the development differentiation of TH17 cells, driving cells toward pathogenic profile. In variety autoimmune disorders, secrete proinflammatory cytokines, including IL-17, contributing to pathophysiology. Our studies others have implicated IL-17 cell dysregulation endometriosis, associated with severity. this article, we...
Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to exhibit aberrant immune responses within lesion microenvironment and circulation contribute development of endometriosis. Thymic stromal lymphopoietin (TSLP) an alarmin involved cell proliferation induction T helper 2 (Th2) inflammation various diseases, such as asthma, atopic dermatitis, pancreatic breast cancer. Recent studies detected TSLP...
Endometriosis is an inflammatory gynaecologic disease characterized by ectopic growth of endometrial-like tissue, resulting in pelvic pain and infertility. T-helper 9 (Th9) cells play a known role various chronic diseases. Despite parallels between endometriosis Th9-driven diseases, their has not been explored. We investigated Th9 cell involvement pathophysiology using human tissue samples, vitro experiments with human-derived cells, vivo to shed insight on the impact adoptively transferred...
Endometriosis (EM) is characterized by the growth of endometrium-like tissue outside uterus, leading to chronic inflammation and pelvic pain. Lesion proliferation, vascularization, associated are hallmark features EM lesions. The legalization recreational cannabinoids has garnered interest in patient community contributing a greater incidence self medication; however, it remains unknown if possess marked disease-modifying properties. In this study, we assess effects synthetic cannabinoid,...
To identify immune cells, cytokines, and cell transcriptome in the menstrual effluent (ME) of women with endometriosis compared that healthy donors.Live cells were isolated from human ME samples analyzed by flow cytometry to various populations. Selected cytokines same patients evaluated using multiplex cytokine analyses. The population was subsequently profiled NanoString nCounter's PanCancer Immune panel.Academic institution.Surgically confirmed (n = 14) fertile donors 19).None.In-depth...
Objective To determine the involvement of endocannabinoid (EC) family member in pathophysiology endometriosis (EMS). Design Mass spectrometry analysis plasma and tissue samples from patients with EMS, controls, a mouse model EMS messenger RNA immunohistochemistry controls. Setting Academic teaching hospital university. Patient(s) Patients healthy fertile control subjects. Intervention(s) None. Main Outcome Measure(s) Endocannabinoid patient plasma, lesions, endometrial samples. Result(s)...
Endometriosis (EM), characterized by the presence of endometrial-like tissue outside uterus, is leading cause chronic pelvic pain and infertility in females reproductive age. Despite its high prevalence, molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) known to influence several cardinal features this complex disease including pain, vascularization, overall lesion survival, but exact are not known. Utilizing CNR1 knockout (k/o), CNR2...
Endometriosis (EM), characterized by the presence of endometrial-like tissue outside uterus, is leading cause chronic pelvic pain and infertility in females reproductive age. Despite its high prevalence, molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) known to influence several cardinal features this complex disease including pain, vascularization, overall lesion survival, but exact are not known. Utilizing CNR1 knockout (k/o), CNR2...
Endometriosis (EMS) is an inflammatory, gynaecologic disease characterized by the growth of endometrial tissues outside uterus. With no satisfactory therapies or non-invasive diagnostics available, a shift in perspectives on EMS pathophysiology overdue. The implication immune dysregulation pathogenesis and progression has been evolving area research, with numerous inflammatory pathways identified. Traditional theories regarding establishment endometriotic lesions have lacked mechanistic...
Endometriosis (EM), characterized by the presence of endometrial-like tissue outside uterus, is leading cause chronic pelvic pain and infertility in females reproductive age. Despite its high prevalence, molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) known to influence several cardinal features this complex disease including pain, vascularization, overall lesion survival, but exact are not known. Utilizing CNR1 knockout (k/o), CNR2...
Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to exhibit aberrant immune responses within lesion microenvironment and circulation contribute development of endometriosis. Thymic stromal lymphopoietin (TSLP) an alarmin involved cell proliferation induction Th2 inflammation various diseases, such as asthma, atopic dermatitis, pancreatic breast cancer. Recent studies detected TSLP endometriotic...
<title>Abstract</title> Endometriosis (EM), characterized by the presence of endometrial-like tissue outside uterus, is leading cause chronic pelvic pain and infertility in females reproductive age. Despite its high prevalence, molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) known to influence several cardinal features this complex disease including pain, vascularization, overall lesion survival, but exact are not known. Utilizing...
Endometriosis (EM), characterized by the presence of endometrial-like tissue outside uterus, is leading cause chronic pelvic pain and infertility in females reproductive age. Despite its high prevalence, molecular mechanisms underlying EM pathogenesis remain poorly understood. The endocannabinoid system (ECS) known to influence several cardinal features this complex disease including pain, vascularization, overall lesion survival, but exact are not known. Utilizing CNR1 knockout (k/o), CNR2...