A5005521622- Cancer Cells and Metastasis
- Vector-borne infectious diseases
- Ovarian cancer diagnosis and treatment
- Vector-Borne Animal Diseases
- Oral and Maxillofacial Pathology
- Insect Pest Control Strategies
- Viral Infections and Vectors
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Insect and Pesticide Research
Cornell University
2020
California Department of Public Health
2019
The common human-biting tick, Ixodes pacificus, is the primary vector of Lyme disease spirochete, Borrelia burgdorferi sensu stricto (ss) in western North America and has been found to harbor other closely-related spirochetes lato (sl) complex. Between 2008-2015, 11,066 adult 3,815 nymphal I. pacificus five 144 spinpalpis, a commonly collected wildlife were from 42 California counties. sl was detected 1.2% 3.8% adults nymphs, respectively. Results this study indicate genetic diversity...
Areas of a junction between two types epithelia are known to be cancer-prone in many organ systems. However, mechanisms for preferential malignant transformation at the areas remain insufficiently elucidated. Here we report that inactivation tumor suppressor genes Trp53 and Rb1 gastric squamous-columnar (SCJ) epithelium results formation metastatic poorly differentiated neoplasms, which similar human gastroesophageal carcinoma. Unlike transformation-resistant antral cells, SCJ cells contain...
Abstract Many high-grade serous carcinomas (HGSCs) likely originate in the distal region of Fallopian tube’s epithelium (TE) before metastasizing to ovary. Unfortunately, molecular mechanisms promoting malignancy TE are obfuscated, largely due limited primary human gene expression data. Here we report an depth bioinformatic characterization 34 mRNA-seq samples. These samples were prepared from proximal and regions 12 normal tubes. Samples segregated based on their aldehyde dehydrogenase...
Abstract A substantial fraction of ovarian/extra-uterine high-grade serous carcinomas (HGSCs) likely originate in the distal region Fallopian tube’s epithelium (TE) before implanting/metastasizing to ovary. Unfortunately, molecular and cellular mechanisms rendering preferential cancer susceptibility human TE remain insufficiently elucidated, largely due limited primary gene expression data. Here we report an depth bioinformatic characterization 34 cell mRNA-seq samples. These samples were...