A5091129321- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Nutrition, Genetics, and Disease
- DNA and Nucleic Acid Chemistry
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Advanced Proteomics Techniques and Applications
- Gut microbiota and health
- Molecular spectroscopy and chirality
- Advanced Chemical Sensor Technologies
- Metabolism and Genetic Disorders
- Phytoestrogen effects and research
- Drug Transport and Resistance Mechanisms
- Toxic Organic Pollutants Impact
- Cancer, Lipids, and Metabolism
- Pharmacological Effects and Toxicity Studies
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Studies
- Mass Spectrometry Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Acute Kidney Injury Research
National Center for Toxicological Research
2016-2025
United States Food and Drug Administration
2016-2025
Center for Systems Biology
2024
Food and Drug Administration
2021
Center for Drug Evaluation and Research
2020
Triangle
2019
Indianapolis Zoo
2019
Kentucky Science Center
2019
John Wiley & Sons (United States)
2019
Washington Center
2019
Metabolomics is the comprehensive study of metabolome, repertoire biochemicals (or small molecules) present in cells, tissues, and body fluids. The metabolism at global or "-omics" level a rapidly growing field that has potential to have profound impact upon medical practice. At center metabolomics, concept person's metabolic state provides close representation individual's overall health status. This reflects what been encoded by genome, modified diet, environmental factors, gut microbiome....
Atherosclerosis is associated with oxidative stress and inflammation, upregulation of LOX-1, an endothelial receptor for oxidized LDL (oxLDL). Here, we describe generation LOX-1 knockout (KO) mice in which binding oxLDL to aortic endothelium was reduced endothelium-dependent vasorelaxation preserved after treatment ( P <0.01 versus wild-type mice). To address whether functional preservation might lead reduction atherogenesis, crossed KO LDLR fed these 4% cholesterol/10% cocoa butter diet...
Background:Humans are exposed to thousands of man-made chemicals in the environment. Some mimic natural endocrine hormones and, thus, have potential be disruptors. Most these never been tested for their ability interact with estrogen receptor (ER). Risk assessors need tools prioritize evaluation costly vivo tests, instance, within U.S. EPA Endocrine Disruptor Screening Program.Objectives:We describe a large-scale modeling project called CERAPP (Collaborative Estrogen Receptor Activity...
Developing biomarkers for detecting acetaminophen (APAP) toxicity has been widely investigated. Recent studies of adults with APAP-induced liver injury have reported human serum microRNA-122 (miR-122) as a novel biomarker injury. The goal this study was to examine extracellular microRNAs (miRNAs) potential APAP in children. Global levels and urine miRNAs were examined three pediatric subgroups: 1) healthy children (n=10), 2) hospitalized receiving therapeutic doses (n=10) 3) overdose (n=8)....