A5026483030- Acute Ischemic Stroke Management
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Stroke Rehabilitation and Recovery
- Carcinogens and Genotoxicity Assessment
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Palliative Care and End-of-Life Issues
- Dementia and Cognitive Impairment Research
- Critical Race Theory in Education
- Venous Thromboembolism Diagnosis and Management
- Clinical practice guidelines implementation
- Per- and polyfluoroalkyl substances research
- Literacy, Media, and Education
- Healthcare Systems and Practices
- Enhanced Recovery After Surgery
- Pharmacogenetics and Drug Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Health Sciences Research and Education
- Geriatric Care and Nursing Homes
- Patient-Provider Communication in Healthcare
- Prenatal Substance Exposure Effects
- Neuroscience of respiration and sleep
University of Central Lancashire
2013-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
Research Network (United States)
2024
National Institutes of Health
2024
East Cheshire NHS Trust
2023
Grinnell College
2018-2022
Environment and Climate Change Canada
2009-2021
University of North Carolina at Pembroke
2021
American University
2021
Maastricht University
2021
The sensitivity of avian species to the toxic effects dioxin-like compounds (DLCs) varies up 1000-fold among species, and this variability has been associated with interspecies differences in aryl hydrocarbon receptor 1 ligand-binding domain (AHR1 LBD) sequence. We previously showed that LD50 values, based on ovo exposures DLCs, were significantly correlated vitro EC50 values obtained a luciferase reporter gene (LRG) assay measures AHR1-mediated induction cytochrome P4501A COS-7 cells...
Importance Intravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks’ gestation reduces the risk of death and cerebral palsy in their children. The effects later gestational ages are unclear. Objective To determine whether administration 34 or 2 years. Design, Setting, Participants This randomized clinical trial enrolled expected deliver was conducted 24 Australian New Zealand hospitals between January 2012 April 2018. Intervention (4 g) compared...
There are large differences in sensitivity to the toxic and biochemical effects of dioxins dioxin-like compounds (DLCs) among vertebrates. Previously, we demonstrated that difference between domestic chicken (Gallus gallus domesticus) common tern (Sterna hirundo) aryl hydrocarbon receptor 1 (AHR1)-dependent changes gene expression following exposure 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is based upon identities amino acids at two sites within ligand binding domain AHR1 (chicken--highly...
Introduction Stroke is a leading cause of adult neurologic disability, cognitive decline, and death worldwide, particularly in Africa. research Africa has exposed challenges militating against the translation evidence into practice policy. The evidence-based, context-sensitive multilevel strategies required to surmount these are presented this report on first African Leaders' Summit (ASLS) organized tackle burden stroke Methods Africa–UK Partnership (AUKSP) Project had Steering Committee...
Relative potencies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 2,3,7,8-tetrachlorodibenzofuran (TCDF) were determined in vitro primary hepatocyte cultures chicken (Gallus gallus), ring-necked pheasant (Phasianus colchicus), Japanese quail (Coturnix japonica) embryos. Concentration-dependent effects on ethoxyresorufin O-deethylase (EROD) activity expression cytochrome P4501A4 P4501A5 (CYP1A4 CYP1A5) messenger RNA (mRNA) hepatocytes exposed to...
Background Accurate dispatch of emergency medical services at the onset acute stroke is vital in expediting assessment and treatment. We examined relationship between callers' description potential symptoms to dispatcher subsequent classification prioritisation response. Aim To identify key ‘indicator’ words used by people making calls for suspected stroke, comparing these with category response given dispatcher. Method A retrospective chart review (hospital services) North West England...
Stroke mortality and morbidity is expected to rise. Despite considerable recent advances within acute ischemic stroke treatment, scope remains for development of widely applicable neuroprotective agents. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally licensed the management Type 2 Diabetes Mellitus, have demonstrated pre-clinical efficacy in a range neurodegenerative conditions. This systematic scoping review reports basis GLP-1RAs as agents their translation into clinical...
In vitro screening tools and 'omics methods are increasingly being incorporated into toxicity studies to determine mechanistic effects of chemicals mixtures. To date, the majority these have been conducted with well-characterized laboratory animal models. present study, well-established developed for chicken embryonic hepatocyte (CEH) were extended a wild avian species, double-crested cormorant (DCCO; Phalacrocorax auritus), in order compare several environmental contaminants on...
Stroke is a time-dependent medical emergency in which early presentation to specialist care reduces death and dependency. Up 70% of all stroke patients obtain first contact from the Emergency Medical Services (EMS). Identifying 'true stroke' an EMS call challenging, with over 50% strokes being misclassified. The aim this study was evaluate impact training package on recognition by Dispatchers (EMDs).This took place ambulance service hospital England using interrupted time-series design....
Aims and objectives. To develop local stroke services by involving, in a meaningful way, those affected identifying prioritising service development issues. Background. Consideration should be given to including the views of users evaluation re‐design services. In stroke, involvement patients carers has generally been at consultative level. There is need explore strategies engage more fully with agenda. Design. Action research. Methods. Within Reflection Phase this action research study...