A5013753442- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Effects and risks of endocrine disrupting chemicals
- Advanced Chemical Sensor Technologies
- Toxic Organic Pollutants Impact
- Pesticide Residue Analysis and Safety
- Mass Spectrometry Techniques and Applications
- Meat and Animal Product Quality
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Carcinogens and Genotoxicity Assessment
- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Pesticide Exposure and Toxicity
- Phytochemistry and Biological Activities
- Health, Environment, Cognitive Aging
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Pharmaceutical and Antibiotic Environmental Impacts
- Antioxidant Activity and Oxidative Stress
- Diet and metabolism studies
- Free Radicals and Antioxidants
- Spectroscopy and Chemometric Analyses
- Analytical chemistry methods development
Toxalim Research Centre in Food Toxicology
2016-2025
Université de Toulouse
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2002-2025
Université Toulouse III - Paul Sabatier
2016-2025
École Nationale Vétérinaire de Toulouse
2016-2025
Laboratoire d'Informatique Fondamentale de Lille
1997-2023
MetaboHUB
2017-2021
Centre National de la Recherche Scientifique
2002-2020
Institut National des Sciences Appliquées de Toulouse
2020
Roquette Frères (France)
2020
Large-scale suspect and non-targeted screening approaches based on high-resolution mass spectrometry (HRMS) are today available for chemical profiling holistic characterisation of biological samples. These advanced techniques allow the simultaneous detection a large number features, including markers human exposure. Such interest biomonitoring, environmental health studies support to risk assessment. Furthermore, these have promising capability detect chemicals emerging concern (CECs),...
We investigated the metabolic fate of a low dose (25 micro g/kg) bisphenol A [2,2-bis(4-hydroxy-phenyl)propane] (BPA) injected subcutaneously in CD1 pregnant mice using tritium-labeled molecule. Analytic methods were developed to allow radio-chromatographic profiling BPA residues excreta and tissues, as well mothers' reproductive tracts fetuses, that contained more than 4% administered radioactivity. was extensively metabolized by mice. Identified metabolite structures included glucuronic...
Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated effects pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. Objectives: We aimed to evaluate, mice, consequences chronic dietary mixture nontoxic doses, relevant consumers' assessment. Methods: A six commonly used France, i.e., boscalid,...
The question of whether exposure to bisphenol A (BPA) contributes the development type 2 diabetes is still unresolved. Most epidemiological evidence on association between BPA and from cross-sectional studies or longitudinal with single urinary measurements. No prospective study has examined analogs such as S (BPS) in relation incident diabetes.We aimed investigate BPS, assessed at up two time points, was associated incidence performed a case-cohort 755 participants without baseline...
Abstract Background High resolution mass spectrometry (HRMS) is being used increasingly in the context of suspect and non-targeted screening for identification bioorganic molecules. There correspondingly increasing awareness that higher confidence will require a systematic, group effort to increase fraction compounds with tandem spectra available central, publicly resources. While typical efforts only result tentative annotations moderate level confidence, library spectral matches yield or...
Although the exposure assessment of chemicals emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and development highly sophisticated analytical instruments, lack standardisation harmonisation workflows method performance for suspect non-target screening hampers interpretation results, their comparability thus, its transmission to policymakers. To date, unlike other research fields such as forensics or food analysis, there is...
Infections by multidrug-resistant Enterobacteriaceae (MRE) are life-threatening to patients. The intestinal microbiome protects against MRE colonization, but antibiotics cause collateral damage commensals and open the way colonization subsequent infection. Despite significance of this problem, specific mechanisms that restrict remain largely unknown. Here, performing a multi-omic prospective study hospitalized patients combined with mice experiments, we find Lactobacillus is key, though not...
Abstract Biotransformation of imidacloprid and the appearance olefin 5‐hydroxyimidacloprid metabolites in honeybee were studied by HPLC‐MS/MS analysis. Honeybees treated orally with at 20 50 µg kg −1 bee. Imidacloprid was metabolised relatively quickly thoroughly. Twenty minutes after beginning ingestion, sum residues from three compounds amounted to only 70% actual given dose. Imidacloprid, represented, respectively, 50%, 9% 8% ingested Six 24 h, ingestion bee, could no longer be detected...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMercapturic Acid Conjugates as Urinary End Metabolites of the Lipid Peroxidation Product 4-Hydroxy-2-nonenal in RatJacques Alary, Fabienne Bravais, Jean-Pierre Cravedi, Laurent Debrauwer, Dinesh Rao, and George BoriesCite this: Chem. Res. Toxicol. 1995, 8, 1, 34–39Publication Date (Print):January 1995Publication History Published online1 May 2002Published inissue 1 January...
The flame retardant tetrabromobisphenol A (TBBPA) is a high production that interferes with thyroid hormone (TH) signaling. Despite its rapid metabolism in mammals, TBBPA found significant amounts different tissues. Such findings highlight first need to better understand the effects of and metabolites second develop models address these questions experimentally. We used Xenopus laevis tadpoles follow radiolabeled 14C-TBBPA uptake metabolism. Extensive radioactivity was observed, metabolizing...
Chemicals of Emerging Concern (CECs) include a very wide group chemicals that are suspected to be responsible for adverse effects on health, but which limited information is available. Chromatographic techniques coupled with high-resolution mass spectrometry (HRMS) can used non-targeted screening and detection CECs, by using comprehensive annotation databases. Establishing database focused the CECs in human samples will provide new insight into distribution extent exposures range humans.This...
Within the Human Biomonitoring for Europe initiative (HBM4EU), a study to determine new biomarkers of exposure pesticides and assess patterns was conducted. urine samples (N = 2,088) were collected from five European regions in two different seasons. The objective identify their metabolites with harmonized suspect screening approach based on liquid chromatography coupled high resolution mass spectrometry (LC-HRMS) applied laboratories. A combined data processing workflow included...
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, prevent adverse impacts environmental health associated with hazardous chemicals. Surveillance of chemicals known, emerging, or potential future concern, entering environment-food-human continuum needed document reality risks posed by ecosystem from a one perspective, feed into early warning systems support public policies for exposure...
Twelve naturally occurring glucosinolates displaying alkenyl, hydroxylated, methylsulphinyl, aromatic and indole side chains were investigated by both negative positive ion electrospray ionisation-tandem mass spectrometry (ESI-MS/MS). In order to resolve the MS/MS spectra obtained from anion cation molecular ions of glucosinolates, different fragments MSn experiments using an trap spectrometer. The MS3 permitted possible fragmentation schemes be proposed. These supported accurate...