Ronan Roussel
A5057869899- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Diabetic Foot Ulcer Assessment and Management
- Birth, Development, and Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ion Transport and Channel Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Diabetes Management and Education
Hôpital Bichat-Claude-Bernard
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2015-2024
Université Paris Cité
2015-2024
Université Claude Bernard Lyon 1
2014-2024
Sorbonne Paris Cité
2013-2024
Institut Necker Enfants Malades
2022-2024
Centre de Recherche des Cordeliers
2014-2023
Sorbonne Université
2012-2023
Centre National de la Recherche Scientifique
2022-2023
To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort develop, evaluate, illustrate revised models. Here, we report the derivation, validation, illustration of charts that have been adapted circumstances 21 global regions.
<h3>Importance</h3> The prevalence of cardiometabolic multimorbidity is increasing. <h3>Objective</h3> To estimate reductions in life expectancy associated with multimorbidity. <h3>Design, Setting, and Participants</h3> Age- sex-adjusted mortality rates hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years baseline surveys: 1960-2007; latest follow-up: April 2013; 128 843 deaths). HRs...
Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as major comorbidity for COVID-19 severity. However, phenotypic characteristics of diabetes in patients are unknown. We conducted nationwide multicentre observational study people with hospitalised 53 French centres period 10–31 March 2020. The primary outcome combined tracheal intubation mechanical ventilation...
Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators
Evidence relating to the impact of COVID-19 in people with diabetes (PWD) is limited but continuing emerge. PWD appear be at increased risk more severe infection, though evidence quantifying highly uncertain. The extent which clinical and demographic factors moderate this relationship unclear, signals are emerging that link higher BMI HbA1c worse outcomes COVID-19. As well as posing direct immediate risks PWD, also contributing due disruptions caused by pandemic, including stress changes...
Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose correlate with various parameters glucose homeostasis susceptibility to type 2 diabetes (T2D). Shotgun lipidomic analysis mice from different genetic backgrounds, which develop a pre-diabetic state at rates when metabolically stressed, led identification group sphingolipids correlated...
OBJECTIVE To compare insulin glargine 300 units/mL (Gla-300) versus degludec 100 (IDeg-100) in this first head-to-head randomized controlled trial. RESEARCH DESIGN AND METHODS BRIGHT (NCT02738151) was a multicenter, open-label, active-controlled, two-arm, parallel-group, 24-week, noninferiority study insulin-naive patients with uncontrolled type 2 diabetes. Participants were 1:1 to evening dosing Gla-300 (N = 466) or IDeg-100 463), titrated fasting self-monitored plasma glucose of 80–100...
Abstract Aims/hypothesis This is an update of the results from previous report CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe outcomes prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The initiative a French nationwide multicentre study COVID-19 28-day follow-up. were screened after hospital admission 10 March April 2020. We mainly focused on discharge death within 28 days. Results included 2796...
OBJECTIVE The RELIEF study assessed rates of hospitalization for acute diabetes complications in France before and after initiation the FreeStyle Libre system. RESEARCH DESIGN AND METHODS A total 74,011 patients with type 1 or 2 who initiated system were identified from French national claims database use ICD-10 codes, hospitalizations as a contributing diagnosis, prescription insulin. Patients subclassified based on self-monitoring blood glucose (SMBG) strip acquisition prior to starting...
The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with die, on average, 6 years earlier than without diabetes. We aimed to provide reliable estimates the associations between at diagnosis and all-cause mortality, cause-specific reductions in life expectancy.
OBJECTIVE Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes. RESEARCH DESIGN AND METHODS Participants were 3,615 middle-aged men women, with normal baseline fasting glycemia (FG), who recruited in 9-year follow-up study. Odds ratios (ORs) 95% CIs the incidence hyperglycemia (FG ≥6.1 mmol/L or treatment diabetes) calculated according to daily water classes based on...
Vasopressin plays a central role in water homeostasis but it has also been recognized to be associated with adverse effects several chronic diseases. Recently, copeptin increasingly used as surrogate for vasopressin, they are co-secreted, and is easier measure. However, the relationship between plasma concentrations of (P(cop)) vasopressin (P(vp)) only studied relatively small numbers selected people.This study sought evaluate P(vp) P(cop) community-based population people kidney disease...
The question of whether exposure to bisphenol A (BPA) contributes the development type 2 diabetes is still unresolved. Most epidemiological evidence on association between BPA and from cross-sectional studies or longitudinal with single urinary measurements. No prospective study has examined analogs such as S (BPS) in relation incident diabetes.We aimed investigate BPS, assessed at up two time points, was associated incidence performed a case-cohort 755 participants without baseline...
Background: The prevalence of abdominal obesity and type 2 diabetes mellitus (T2DM) is a public health challenge. New solutions need to be developed help patients implement lifestyle changes. Objective: objective the study was evaluate fully automated Web-based intervention designed users improve their dietary habits increase physical activity. Methods: Accompagnement Nutritionnel de l'Obésité et du Diabète par E-coaching (ANODE) 16-week, 1:1 parallel-arm, open-label randomized clinical...
To compare steady state pharmacodynamic and pharmacokinetic profiles of insulin glargine 300U/mL (Gla-300) with degludec 100U/mL (Deg-100) in people type 1 diabetes.This single-centre, randomized, double-blind crossover euglycaemic clamp study included two parallel cohorts fixed once-daily morning dose regimens. For both insulins participants received 0.4 (n=24) or 0.6U/kg/day (n=24), before breakfast, for 8 days prior to the clamp. The main endpoint was within-day variability (fluctuation)...