A5039178481- Pituitary Gland Disorders and Treatments
- Diabetes Management and Research
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Diabetes Management and Education
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Healthcare Systems and Practices
- Hormonal and reproductive studies
- Health, Medicine and Society
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Biology and Fertility
- Glioma Diagnosis and Treatment
- Estrogen and related hormone effects
- Gestational Diabetes Research and Management
- Thyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
Centre Hospitalier Régional Universitaire de Brest
2016-2025
Université de Bretagne Occidentale
2013-2025
Hôpital Maison Blanche
2012-2024
Inserm
2003-2024
Service de la Santé Publique
2003-2020
Centre Hospitalier Universitaire de Caen
2019
Université de Caen Normandie
2019
Assistance Publique – Hôpitaux de Paris
2018
HRA Pharma (France)
2018
Université de Bourgogne
2015
The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects (or at risk for) type 2 diabetes mellitus are unknown.In this double-blind study a 2-by-2 factorial design, we randomly assigned 12,536 who were high for and had impaired fasting glucose, glucose tolerance, to receive 1-g capsule containing least 900 mg (90% more) ethyl esters placebo daily either insulin glargine standard care. primary outcome was death...
Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as major comorbidity for COVID-19 severity. However, phenotypic characteristics of diabetes in patients are unknown. We conducted nationwide multicentre observational study people with hospitalised 53 French centres period 10–31 March 2020. The primary outcome combined tracheal intubation mechanical ventilation...
What are the prevalence and outcomes of spontaneous pregnancies (SP) in a large cohort French women with Turner syndrome (TS)?Amongst 480 TS, 27 (5.6%) had total 52 SP, 30 full-term deliveries for 18 women.Primary ovarian insufficiency is classic feature TS. So far, few studies have evaluated rate SP these patients.The Ministry Health set up National Reference Centre Rare Growth Disorders (CRMERC), including We studied adult TS patients from seven endocrine units (Saint-Antoine,...
Three genes encoding for mitochondrial complex II proteins are linked to hereditary paraganglioma. We have recently shown that an inactivation of the SDHD gene is associated with a complete loss activity and stimulation angiogenic pathway (Gimenez-Roqueplo, A. P., J. Favier, P. Rustin, Mourad, F. Plouin, Corvol, Rötig, X. Jeunemaitre, 2001, Am J Hum Genet 69:1186–1197). Here, we relate case malignant sporadic pheochromocytoma induced by germline missense mutation SDHB gene. Within tumor,...
Context Germline mutations in the aryl hydrocarbon receptor interacting protein gene ( AIP ) have been identified young patients (age ≤30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning prevalence of multiple endocrine neoplasia type 1 MEN1 such a population. Objective We assessed both and genetic abnormalities (mutations large deletions) diagnosed isolated macroadenoma, without hypercalcemia and/or MEN1-associated lesions. Design The entire coding...
Outcomes of congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency (21OHD) have been widely studied in children and women, but less so men.The objective was analyze data from a network metropolitan French teaching hospitals on the clinical outcome 21OHD large sample hyperplasia/21OHD-genotyped adult men, particularly impact gonadotrope axis, testicular function, fertility.From April 2011 June 2014, tertiary endocrinology departments provided for 219 men with (ages, 18-70 y;...
Activated protein C (APC) resistance not related to the factor V Leiden mutation is a risk for venous thrombosis. Oral estrogen replacement therapy (ERT) has been reported induce APC resistance. Little known about effect of transdermal estrogen.We enrolled 196 postmenopausal women who were randomly allocated receive either 1 mg 17beta-estradiol orally (n=63) or 50 microg transdermally per day (n=68), both associated with 100 progesterone daily placebo (n=65) 6 months. An activated partial...
Multiple endocrine neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, a rare autosomal-dominant disease that predisposes carriers tumors. Although genotype-phenotype studies have so far failed identify any statistical correlations, some families harbor recurrent tumor patterns. The function MENIN unclear, but has been described through discovery its interacting partners. Mutations in domains functional partners shown directly alter regulation abilities. We...
Familial isolated pituitary adenoma (FIPA) occurs in families and is unrelated to multiple endocrine neoplasia type 1 Carney complex. Mutations AIP account only for 15–25% of FIPA families. CDKN1B mutations cause MEN4 which affected patients can suffer from adenomas. With this study, we wanted assess whether occur among a large cohort mutation-negative kindreds. Eighty-eight were studied 124 subjects underwent sequencing . Functional analysis putative was performed using silico vitro...
Adrenocortical cancer (ACC) is an aggressive tumor with a heterogeneous outcome. Prognostic stratification difficult even based on stage and Ki67. Recently integrated genomics studies have demonstrated that CpG islands hypermethylation correlated poor survival. The goal of this study was to confirm the prognostic value methylation independent cohort. Methylation measured by methylation-specific multiplex ligation–dependent probe amplification (MS-MLPA). MS-MLPA performed in training cohort...
Objective Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of somapacitan vs once-daily Norditropin ® . Local tolerability and treatment satisfaction were also assessed. Design 26-week randomized, controlled phase 3 trial in six countries (Nbib2382939). Methods Male or female patients aged 18–79 years with adult GH deficiency (AGHD), treated ≥6 months, randomized ( n = 61) 31)...
Turner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome absent from some cells. It affects approximately every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40-50%) and the 45,X/46,XX mosaic karyotype (15-25%). Karyotypes with an isochromosome (45,X/46,isoXq 45,X/46,isoXp), Y chromosome, ring deletions less frequent. objective French National Diagnosis Care Protocol (PNDS; Protocole de Diagnostic et Soins) to provide health...
Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS). Although KTZ has been associated with severe hepatotoxicity, little information about hepatic safety in CS. The aim this study was to document changes liver function patients CS treated KTZ.An observational prospective French cohort (Compassionate Use Programme (CUP)).Enrolled were stratified into a KTZ-naive and already by another formulation ketoconazole (KTZ-switch cohort). Liver markers (alanine...
<h3>Background</h3> Germline mutations in the <i>SDHD</i> tumour suppressor gene (11q23.1) predispose to phaeochromocytomas and paragangliomas (PPGL) mainly on a paternal transmission. However, PPGL have been recently reported three carriers of maternally inherited mutation. <h3>Objective</h3> To assess risk occurrence maternal transmission <h3>Methods</h3> Pedigrees 80 <i>SDHD</i>-related families reviewed. 35 asymptomatic subjects carrying transmitted mutation were identified. 20 them...
Summary C-reactive protein (CRP) is one of the main independent predictors cardiovascular events. Oral post-menopausal estro-gen replacement therapy (ERT) increases CRP levels, but effect transdermal ERT not well documented. CRP, interleukine-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were evaluated in a randomised study 196 healthy postmenopausal women, who allocated to receive continuous oral estradiol-17β, (n=63) or (n=68) both combined with micronised progesterone, placebo...