A5040128812- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Receptor Mechanisms and Signaling
- Veterinary Medicine and Surgery
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
- Cardiovascular Conditions and Treatments
- Cardiac tumors and thrombi
- Neuropeptides and Animal Physiology
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Estrogen and related hormone effects
- Neuroblastoma Research and Treatments
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
Inserm
2015-2024
Université de Rouen Normandie
2015-2024
Différenciation et Communication Neuronale et Neuroendocrine
2015-2024
Centre Hospitalier Universitaire de Rouen
2015-2024
Neuroendocrine, Endocrine and Germinal Differentiation Communication
2022-2024
École Nationale Vétérinaire de Toulouse
2011-2023
Normandie Université
2014-2023
Université de Caen Normandie
1989-2023
Université de Toulouse
2012-2023
University of California, Los Angeles
2023
Bilateral macronodular adrenal hyperplasia is a rare cause of primary Cushing's syndrome. In this form hyperplasia, hypersecretion cortisol suppresses the release corticotropin by pituitary corticotrophs, which results in low plasma levels. Thus, disease has been termed corticotropin-independent hyperplasia. We examined abnormal production these hyperplastic glands.We obtained specimens tissue from 30 patients with disease. The precursor proopiomelanocortin and expression were assessed means...
Primary aldosteronism (PA) is the main cause of secondary hypertension, resulting from adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia. Here, we show that constitutive activation WNT/β-catenin signalling most frequent molecular alteration found in 70% APA. We provide evidence decreased expression WNT inhibitor SFRP2 may be contributing to deregulated and APA development patients. This supported by demonstration mice with genetic ablation Sfrp2 have increased aldosterone...
Practical relevance: Chronic kidney disease (CKD) is one of the most commonly diagnosed diseases in older cats. In cats, CKD also a progressive and can be accompanied by wide range clinical clinicopathological changes. These ISFM Consensus Guidelines have been developed an independent panel clinicians academics to provide practical advice on diagnosis management this complex disease. Clinical challenges: Although common problem manifestations vary between individuals. Thus there need for...
Primary aldosteronism is the most common form of secondary hypertension with hypokalemia and suppressed renin-angiotensin system caused by autonomous aldosterone production. Our aim was to compare zona glomerulosa (ZG) structure function between control adrenals peritumoral tissue from patients operated on for aldosterone-producing adenoma. ZG morphology CYP11B1, CYP11B2, disabled 2 expression were studied in 15 25 A transcriptome analysis done using publicly available data sets. In...
Abstract Comprehensive genetic analyses have identified germline SDHB and FH gene mutations as predominant causes of metastatic paraganglioma pheochromocytoma. However, some suspicious cases remain unexplained. In this study, we performed whole-exome sequencing a exhibiting an SDHx-like molecular profile in the absence SDHx or mutation SLC25A11 gene, which encodes mitochondrial 2-oxoglutarate/malate carrier. Germline were six other patients, five whom had disease. These associated with loss...
Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by a strong genetic component, with up to 40% of patients carrying germline mutation in PPGL susceptibility gene. International guidelines recommend that screening be proposed all PPGL. Objective Our objective was evaluate how positive test impacts the management outcome SDHx or VHL-related Design We performed multicentric retrospective study involving 221 propositi an SDHB, SDHD, SDHC, VHL mutation. Patients...
Primary objective: To investigate the experiences of individuals who had sustained a traumatic brain injury, their families and physicians health professionals involved, from critical care episodes subsequent rehabilitation.Research design: Semi-structured interviews were conducted with TBI (n = 8) as well (or service providers) 22) 9) provided them care.Main outcomes results: Results revealed difficulties encountered by different people standpoint readjustment individual family,...
Primary pigmented nodular adrenocortical disease (PPNAD), a rare cause of corticotropin-independent Cushing syndrome, can be part Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac myxomas, and endocrine tumors or isolated (i). Germline PRKAR1A-inactivating mutations have been observed in both CNC iPPNAD, but with no apparent genotype-phenotype correlation.The objectives the study were detailed phenotyping for...
Context ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare and heterogeneous condition characterized by abnormal steroid production. Cortisol secretion can be regulated aberrant hormone receptors. Objective A large series of patients with AIMAH were evaluated to provide information on the prevalence profile regulations, in relation functional status. Design Thirty-two consecutive prospectively studied: 10 had Cushing's syndrome (CS), 22 subclinical CS (SCS). Methods baseline...
Aldosterone producing adenoma (APA) is the most common form of surgically curable hypertension. To further understand mechanisms involved in APA formation, we investigated expression molecules linked to adrenal stem/precursor cells [β-catenin, Sonic hedgehog (Shh), CD56], and nuclear receptors that play key roles adrenocortical development function steroidogenic factor 1, dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on X chromosome, gene 1) six control glands 14...
Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a heterogeneous disease characterized by macronodules and variable levels of cortisol excess, with not clearly established clinical diagnostic criteria. It can be caused ARMC5 germline pathogenic variants. In this study, we aimed to identify predictive criteria for variants.We included 352 consecutive index patients from 12 European centers, sequenced alteration. Clinical, biological imaging data were collected retrospectively.52...
Systemic hypertension was diagnosed in 58 of 188 untreated cats referred for evaluation suspected hypertension‐associated ocular, neurologic, cardiorespiratory, and urinary disease, or diseases frequently associated with (hyperthyroidism chronic renal failure). Hypertensive were significantly older than normotensive subjects (13.0 ± 3.5 years versus 9.6 5.0 years; P < .01), had a greater prevalence retinal lesions (48 3%; .001), gallop rhythm (16 0%; polyuria‐polydipsia (53 29%; .01)....
Abstract Objective —To determine left ventricular free wall (LVFW) radial and longitudinal myocardial contraction velocities in healthy dogs via quantitative 2-dimensional color tissue Doppler imaging (TDI). Animals —100 dogs. Procedure —TDI was used by a single trained observer to measure movement the LVFW. Radial were recorded segments endocardial epicardial layers of LVFW, at 3 levels (basal, middle, apical) Results —LVFW higher than layers. Left basal middle apical segments. velocity...
In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing’s syndrome, cortisol production can be controlled by illegitimate membrane receptors. The aim of the present study was to evaluate in vivo and vitro sensitivity AIMAH various regulatory factors detect expression receptors tissues. Four consecutive patients with hypercortisolism (H1–H4) preoperatively underwent a series pharmacological and/or physiological tests. After adrenalectomy, studies were conducted...
It has previously been shown that arginine vasopressin (AVP) exerts a direct stimulatory action on rat adrenocortical cells. In the present study, we have investigated possible effect of AVP cortisol secretion by normal human tissue. The occurrence endogenous in adrenal gland studied means indirect immunofluorescence technique. presence AVP-containing cells was observed both cortex and medulla. corticosteroidogenesis vitro using perifusion system technique coupled to specific RIA for...
ACTH-independent macronodular adrenocortical hyperplasia (AIMAH) is rare and generally presents as a sporadic disease. We describe familial case of AIMAH with in vivo vitro demonstration aberrant 5-HT4 vasopressin adrenal receptors. Two sisters presented clinical biological features mild Cushing’s syndrome bilateral enlargement on computerized tomography (CT)-scan evaluation. In pharmacological tests showed significant increase plasma cortisol after terlipressin metoclopramide...
Many kinds of stress stimulate the neuroendocrine systems controlling catecholamine and glucocorticoid secretion. Stress-induced stimulation CRF-containing neurons appears to be mediated by serotonergic, noradrenergic, possibly other neuronal pathways. Stress can alter various neurobiological endocrine functions, two essential components responses being release adrenalin from chromaffin cells adrenal medulla secretion glucocorticoids adrenocortical cells. Activation steroid is mainly a...