A5024745220- Veterinary Medicine and Surgery
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pediatric Urology and Nephrology Studies
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Vitamin D Research Studies
- Acute Kidney Injury Research
- Antibiotics Pharmacokinetics and Efficacy
- Genetic Syndromes and Imprinting
- Hemoglobin structure and function
- Cardiovascular Conditions and Treatments
- Liver Disease and Transplantation
- Dialysis and Renal Disease Management
- Pharmaceutical studies and practices
- Renal and Vascular Pathologies
- Anesthesia and Sedative Agents
- Renin-Angiotensin System Studies
- Bone health and osteoporosis research
- Thyroid Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hemodynamic Monitoring and Therapy
- Antimicrobial Resistance in Staphylococcus
- Delphi Technique in Research
University of Bristol
2014-2024
The Langton Grammar School for Boys
2022
Harris Health System
2021-2022
Ben Taub Hospital
2022
Baylor College of Medicine
2021
Renal Association
2018-2019
Royal Veterinary College
2011-2018
University of London
2011-2018
At Bristol
2012-2018
Ghent University
2011
Practical relevance: Chronic kidney disease (CKD) is one of the most commonly diagnosed diseases in older cats. In cats, CKD also a progressive and can be accompanied by wide range clinical clinicopathological changes. These ISFM Consensus Guidelines have been developed an independent panel clinicians academics to provide practical advice on diagnosis management this complex disease. Clinical challenges: Although common problem manifestations vary between individuals. Thus there need for...
Background Identification of risk factors for development chronic kidney disease ( CKD ) in cats may aid its earlier detection. Hypothesis/objectives Evaluation clinical and questionnaire data will identify azotemic cats. Animals One hundred forty‐eight client‐owned geriatric (>9 years) Methods Cats were recruited into the study followed longitudinally a variable time. Owners asked to complete regarding their pet at enrollment. Additional dental obtained when available by categorization...
Background Fibroblast growth factor 23 ( FGF ‐23) is a phosphaturic hormone involved in the pathogenesis of secondary renal hyperparathyroidism SRHP ) humans. There are no published studies examining feline ‐23. Objectives Validation method for ‐23 quantification plasma and assessment associations among ‐23, PTH , creatinine, phosphate concentrations cats with chronic kidney disease CKD ). Animals One hundred nonazotemic azotemic geriatric (>9 years) client‐owned cats. Methods...
The endothelial glycocalyx is a key component of the glomerular filtration barrier. We have shown that matrix metalloproteinase (MMP)-mediated syndecan 4 shedding mechanism damage in vitro, resulting increased albumin permeability. Here we sought to determine whether this important early diabetic kidney disease, by studying streptozotocin-induced type 1 diabetes DBA2/J mice. Diabetic mice were albuminuric, had permeability and damage. Syndecan mRNA expression was found be upregulated...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause pandemic disease in the past 2 years, leading significant worldwide morbidity and mortality. At beginning of pandemic, only nonspecific treatments were available, but recently two oral antivirals have received emergency use authorization from U.S. Food Drug Administration for treatment mild moderate coronavirus (COVID-19). Molnupiravir targets viral polymerase causes lethal mutations within virus during...
Background Fibroblast growth factor ( FGF ‐23) has an important role in phosphate regulation. Its clinical relevance cats with CKD not been explored previously. Hypothesis/Objectives The study objectives were (1) to determine whether ‐23 concentrations are increased nonazotemic cats, which developed azotemia within 12 months of screening compared that remained non‐azotemic, and (2) evaluate the relationships between PTH glomerular filtration rate GFR ). Animals Sixty‐two healthy client‐owned...
Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they regulated and their role in disease.
To determine whether cats in the nonazotemic stages of chronic kidney disease have increased plasma parathyroid hormone (PTH) concentrations as a compensatory physiologic mechanism to maintain phosphate concentration within reference interval.Prospective longitudinal study.118 client-owned geriatric with various degrees renal function.For each cat, blood sample was obtained for biochemical analysis and determination PTH concentration, urine specific gravity at study entry (baseline) after 12...
To develop a formula for correcting slope-intercept plasma iohexol clearance in cats and to compare of total (TIox), endo-iohexol (EnIox), exo-iohexol (ExIox).20 client-owned, healthy adult geriatric cats.Plasma TIox was determined via multisample methods. A method used determine EnIox ExIox. second-order polynomial correction factor derived by performing regression analysis the data with forcing line though origin. Clearance corrected use compared Brochner-Mortensen human Heiene canine...
Abstract Background Vancomycin (VAN)-associated acute kidney injury (AKI) is increased when VAN combined with certain beta-lactams (BLs) such as piperacillin-tazobactam (TZP) but has not been evaluated ceftolozane-tazobactam (C/T). Our aim was to investigate the AKI incidence of in combination C/T (VAN/C/T) compared TZP (VAN-TZP). Methods We conducted a multicenter, observational, comparative study across United States. The primary analysis composite outcome and risk, injury, failure, loss,...
This case series describes two young sibling cats and an additional unrelated cat, from separate households, that developed hypercalcaemia associated with hypervitaminosis D. Excessive vitamin D concentrations were identified in a natural complementary tinned kitten food was fed to all three as part of their diet. In one the cases, there clinical evidence soft tissue mineralisation. The mineralisation resolved following withdrawal affected medical management hypercalcaemia.This demonstrates...
To describe the effect of low-dose (111MBq) radioiodine therapy on thyroid and renal function in hyperthyroid cats over a 12-month follow-up period.Client-owned underwent were followed-up for 12 months. Immediately before treatment, at 1, 6 months afterwards, total thyroxine, stimulating hormone, serum creatinine glomerular filtration rate measured.Fifteen 24 (63%) achieved euthyroidism following treatment. The incidence overt hypothyroidism was six (25%) cats. Of developing hypothyroidism,...
Fifty client‐owned senior cats (32 normotensive and 18 hypertensive) with renal function ranging from normal to moderately reduced were recruited into a prospective cross‐sectional study exploring the association of urinary cadmium excretion hypertension in cats. Heparinised plasma samples collected analysed for routine biochemical parameters. Urine via cystocentesis concentrations using inductively coupled mass spectrometry (ICP‐MS). Blood pressure was measured Doppler method. Urinary...
Outpatient parenteral antibiotic therapy (OPAT) is an attractive option for patients who require antimicrobials as outpatients. Few OPAT studies have assessed the impact of IV via elastomeric continuous pumps, with most having been conducted outside United States and few in county hospitals. The program Harris Health system, hospital system Houston, Texas, States, has implemented a disposable infusion pump (eCIP) self-administered intravenous antibiotics (s-OPAT) since December 2018. Our...
Background Validated methods of estimating glomerular filtration rate ( GFR ) in cats requiring only a limited number samples are desirable. Hypothesis/Objectives To test single sample method determining cats. Animals The validation population (group 1) consisted 89 client‐owned (73 nonazotemic and 16 azotemic). A separate 18 healthy 2) was used to the methods. Methods Glomerular determined group 1 using corrected slope‐intercept iohexol clearance. Single clearance Jacobsson modified...
Objectives The aim of this study was to describe the variability in renal function markers non-azotaemic and azotaemic cats, also rate change markers. Methods Plasma creatinine concentration its reciprocal, glomerular filtration (GFR) urine specific gravity (USG) were studied as client-owned cats. GFR determined using a corrected slope-intercept iohexol clearance method. Renal testing performed at baseline second time point. within-population (coefficient variation; CV%) Within-individual...
Background Estimated glomerular filtration rate (eGFR) formulas are routinely used in human patients to provide a more accurate evaluation of GFR compared serum creatinine concentration alone. Similar do not exist for cats. Objectives To validate prediction formula eGFR cats based on adjusting concentration. Animals Client‐owned with various levels renal function. Methods The study was cross‐sectional. Glomerular determined by iohexol clearance. Variables including signalment, biochemical...