A5042100504- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Microbial infections and disease research
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Bacterial Genetics and Biotechnology
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Drug-Induced Adverse Reactions
- Infective Endocarditis Diagnosis and Management
- Medical Education and Admissions
- Acute Kidney Injury Research
- Acne and Rosacea Treatments and Effects
- Monoclonal and Polyclonal Antibodies Research
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Sleep and related disorders
Nova Southeastern University
2017-2025
Memorial Hospital
2024
Memorial Healthcare System
2024
Primus Consulting (United States)
2024
Health Net
2024
Kaiser Permanente
2024
Wayne State University
2021-2023
Eugene Applebaum College of Pharmacy and Health Sciences
2021-2023
Sleep is critical for repair as well the rejuvenation processes in body and many of these functions are regulated via underlying cellular metabolic homeostasis. Changes sleep pattern reported to alter such function resulting altered disease susceptibility or behavior. Here, we measured extent which overnight total deprivation (SD) young adult humans can influence systemic (plasma-derived) redox-metabolism including major antioxidant, glutathione DNA methylation levels. Nineteen participants...
Multi-drug resistant gram-negative bacteria present a significant global health threat. Cefiderocol (CFDC), siderophore cephalosporin, has shown potential in combating this threat, but with the currently available data, its role therapy remains poorly defined. This multi-center, retrospective cohort study evaluated real-world application of CFDC across six U.S. medical centers from January 2018 to May 2023. Patients aged ≥18 years and who had received ≥72 hours were included. The primary...
Bacterial biofilms are difficult to eradicate and can complicate many infections by forming on tissues medical devices. Phage+antibiotic combinations (PAC) may be more active than either type of agent alone, but it is predict which PAC regimens will reliably effective. To establish a method for screening against Staphylococcus aureus biofilms, we conducted biofilm time-kill analyses (TKA) using various phage Sb-1 with clinically relevant antibiotics. We determined the activity versus...
Phage therapy has gained attention due to the spread of antibiotic-resistant bacteria and narrow pipeline novel antibiotics. cocktails are hypothesized slow overall development resistance by challenging with more than one phage. Here, we have used a combination plate-, planktonic-, biofilm-based screening assays try identify phage-antibiotic combinations that will eradicate preformed biofilms Staphylococcus aureus strains otherwise difficult kill. We focused on methicillin-resistant S (MRSA)...
Infections due to nontuberculous mycobacteria (NTM) continue increase in prevalence, leading problematic clinical outcomes. Omadacycline (OMC) is an aminomethylcycline antibiotic with FDA orphan drug and fast-track designations for pulmonary NTM infections, including
Here, we investigate the impact of phage-antibiotic combinations (PAC) on bacterial killing, resistance development and outer membrane vesicle (OMV) production in multidrug-resistant (MDR) P. aeruginosa.After screening 10 well-characterized MDR aeruginosa strains against three phages, representative strains, R10266 R9316, were selected for synergy testing based high phage sensitivity substantial antibiotic patterns, while EM was chosen host range. To understand aeruginosa, time-kill...
Multidrug-resistant (MDR) Enterococcus faecium is a challenging nosocomial pathogen known to colonize medical device surfaces and form biofilms. Bacterio (phages) may constitute an emerging anti-infective option for refractory, biofilm-mediated infections. This study evaluates eight MDR E. strains biofilm production phage susceptibility against nine phages. Two isolated from patients with bacteremia identified be producers, R497 (daptomycin (DAP)-resistant) HOU503 (DAP-susceptible...
Abstract Background Complicated skin and soft tissue infections (cSSTIs) caused by resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA) require effective treatment. Vancomycin is the standard-of-care for MRSA-associated cSSTIs, but its efficacy questioned due to poor penetration. Ceftaroline, an anti-MRSA cephalosporin with improved penetration, may offer better outcomes. This real-world study compares effectiveness of ceftaroline vancomycin in treating cSSTIs. Methods...
Abstract A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There mixed infection sources, pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%), and 15/16 (94%) isolates multidrug-resistant. Thirty-day survival occurred in 14/21 (67%) patients. Two experienced adverse effects.
The Centers for Disease Control and Prevention (CDC) categorized carbapenem-resistant Enterobacterales (CRE) infections as an "urgent" health care threat requiring public attention research. Certain patients with CRE may be at higher risk poor clinical outcomes than others. Evidence on or protective factors are warranted in order to determine the most at-risk populations, especially newer beta-lactam/beta-lactamase inhibitor (BL/BLI) antibiotics available treat CRE. We aimed identify...
Limited data suggest that serious infections caused by Enterobacterales with a moderate to high risk of clinically significant AmpC production can be successfully treated cefepime if the minimum inhibitory concentration (MIC) is ≤2 µg/mL. However, isolates cefepime-susceptible dose-dependent (SDD) MIC 4-8 µg/mL should receive carbapenem due target attainment and extended-spectrum β-lactamase (ESBL) concerns.This was retrospective cohort study hospitalized patients E. cloacae, K. aerogenes,...
Abstract Drug‐resistant tuberculosis (TB) is a major public health concern and contributes to high morbidity mortality. New evidence supports the use of shorter duration, all‐oral regimens, which represent an encouraging treatment strategy for drug‐resistant TB. As result, landscape TB pharmacotherapy has drastically evolved regarding principles preferred agents. This narrative review focuses on key updates treatment, including short‐duration while calling attention current gaps in knowledge...
Multidrug-resistant (MDR) Enterococcus faecium is a challenging pathogen known to cause biofilm-mediated infections with limited effective therapeutic options. Lytic bacteriophages target, infect, and lyse specific bacterial cells have anti-biofilm activity, making them possible treatment option. Here, we examine two biofilm-producing clinical E. strains, daptomycin (DAP)-resistant R497 DAP-susceptible dose-dependent (SDD) HOU503, initial susceptibility bacteriophage 113 (ATCC 19950-B1). An...
We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant Acinetobacter baumannii necrotizing pneumonia complicated by empyema in Detroit, Michigan. A precision medicine approach using whole-genome sequencing, susceptibility testing, synergy analysis guided the selection of rational combination antimicrobial therapy.
Biofilm-producing
Abstract Background Vancomycin (VAN)-associated acute kidney injury (AKI) is increased when VAN combined with certain beta-lactams (BLs) such as piperacillin-tazobactam (TZP) but has not been evaluated ceftolozane-tazobactam (C/T). Our aim was to investigate the AKI incidence of in combination C/T (VAN/C/T) compared TZP (VAN-TZP). Methods We conducted a multicenter, observational, comparative study across United States. The primary analysis composite outcome and risk, injury, failure, loss,...
Infections caused by multidrug-resistant (MDR), extensively drug-resistant (XDR), and difficult-to-treat (DTR) Pseudomonas aeruginosa are increasingly challenging to combat. Ceftolozane-tazobactam (C/T) is a novel β-lactam-β-lactamase inhibitor combination now commonly used treat MDR XDR P. aeruginosa. Lower respiratory tract infections (LRTIs) remain the most common source of infection MDR/XDR Comparative effectiveness studies date have been limited type comparator agents (i.e.,...
Enterococcus faecium is a significant multidrug-resistant pathogen. Bacteriophage cocktails are being proposed to complement antibiotic therapy.
Biofilm-associated infections lead to substantial morbidity. Omadacycline (OMC) is a novel aminomethylcycline with potent
ABSTRACT Pseudomonas aeruginosa -associated infective endocarditis represents difficult-to-treat, deep-seated infections. Phage-antibiotic combinations have shown to eradicate multi-drug resistant (MDR) P. , limit the development of phage resistance, and restore antibiotic sensitivity. The objective this study was evaluate activity phage-ciprofloxacin (CIP) in 4-day ex vivo simulated endocardial vegetation (SEV) models against drug-resistant isolates. Two isolates, extensively AR351 MDR...