A5087474187- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pediatric Urology and Nephrology Studies
- Antimicrobial Resistance in Staphylococcus
- Bladder and Urothelial Cancer Treatments
- Gastrointestinal disorders and treatments
- Infection Control in Healthcare
- Mobile Health and mHealth Applications
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Infective Endocarditis Diagnosis and Management
- Intestinal and Peritoneal Adhesions
- Healthcare Policy and Management
- Pharmaceutical Practices and Patient Outcomes
- Data-Driven Disease Surveillance
- Nosocomial Infections in ICU
- Tuberculosis Research and Epidemiology
- Pharmacological Effects and Toxicity Studies
- Telemedicine and Telehealth Implementation
- Biliary and Gastrointestinal Fistulas
- Traditional Chinese Medicine Studies
Medical University of South Carolina
2017-2025
Hôpital Saint Eloi
2025
bioMérieux (United States)
2023-2024
Northeastern University
2015-2022
University Medical Center
2022
University of Bahrain
2014
Increasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 urine that were collected from emergency department/hospitalized patients. Fosfomycin nitrofurantoin most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, ampicillin ≤40%; empirical use these likely provides inadequate coverage in areas with...
Bacterial resistance among uropathogens is on the rise and has led to a decreased effectiveness of oral therapies. Fosfomycin tromethamine (fosfomycin) indicated for uncomplicated urinary tract infections (UTIs) displays in vitro activity against multidrug-resistant (MDR) isolates; however, clinical data assessing fosfomycin treatment complicated or MDR UTIs are limited.We conducted retrospective evaluation patients who received ≥1 dose between January 2009 September 2015 UTI. Patients were...
Abstract Background The escalating prevalence of multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to patient care due its limited treatment options. However, imipenem-cilastatin-relebactam (IMI/REL) is promising beta-lactam/beta-lactamase inhibitor combination with expanded activity against MDR P. aeruginosa. This study aimed explore the characteristics, efficacy and safety IMI/REL for infections aeruginosa.Table 1.Patient infection characteristics. Methods was...
Abstract Background Multidrug-resistant (MDR) Gram-negative infections are a substantial threat to patients and public health. Imipenem/cilastatin/relebactam (IMI/REL) is beta-lactam/beta-lactamase inhibitor with expanded activity against MDR Pseudomonas aeruginosa carbapenem-resistant Enterobacterales. This study aims describe the patient characteristics, prescribing patterns, clinical outcomes associated IMI/REL. Methods was retrospective, multicenter, observational of ≥18 years old who...
Abstract A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There mixed infection sources, pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%), and 15/16 (94%) isolates multidrug-resistant. Thirty-day survival occurred in 14/21 (67%) patients. Two experienced adverse effects.
Abstract The antimicrobial resistance (AMR) surveillance landscape in the United States consists of a data flow that starts clinical setting and is maintained by network national state public health laboratories. These organizations are well established, with robust methodologies to test confirm susceptibility. Still, bridge guides often one directional caught constant rush hour can only be refined improvements infrastructure automation flow. Moreover, there an absence information literature...
The use of tablet computers and other touch screen technology within the healthcare system has rapidly expanded. It been reported that these devices can harbor pathogens in hospitals; however, much less is known about what they when used outside hospital environment compared to practice.Thirty iPads belonging faculty with a variety practice settings were sampled determine presence quantity clinically-relevant organisms. Flocked nylon swabs neutralizer solution sample surface each iPad....
Abstract Objective: To evaluate the effects early de-escalation of antipseudomonal β-lactam (APBL) on 90-day CDI risk in Enterobacterales bloodstream infections (BSIs). Design: Retrospective cohort analysis. Setting: An academic medical center South Carolina. Patients: We included patients aged >18 years with monomicrobial BSIs who received APBL between July 1, 2015, and June 30, 2020. Methods: Rates were compared an for >72 hours <72 hours, followed by comparison formulary APBLs...
Abstract Background: With increases in antimicrobial resistance, it is crucial that patients receive appropriate therapy a timely manner. Advancements rapid diagnostics offer the ability to identify resistant organisms quickly. However, this technology not always accessible and relies on correct specimen collection. While awaiting new microbiology methods, may be beneficial risk factors associated with common types of resistance. Specifically, extended-spectrum β-lactamase-producing...
Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate and may lead to adverse events. This 2-center, retrospective cohort study including emergency department or inpatient adults identified pyuria (odds ratio, 2.43; 95% confidence interval, 1.17-5.01; P = .02) as the only independent risk factor for antibiotic ASB.
Acute infectious diarrhea is a leading cause of hospitalizations, outpatient visits, and lost quality life in the United States. Rapid diagnostic technology may provide an opportunity to quickly optimize ABX therapy for acute diarrhea. The GIP multiplex PCR test that detects 13 bacteria, 5 viruses, 4 parasites approximately 1 hour run time. Our objective was determine frequency alterations empiric within 48 hours reporting results. Patients had performed on diarrheagenic stool while our...
Abstract Background A multidisciplinary approach using pre-authorization and/or prospective audit and feedback combined with institutional guidelines, personnel education, intervention monitoring is essential for successful antimicrobial stewardship programs (ASP). Assessing the impact of ASPs can be process-based outcome-based. Electronic medical record-based clinical decision support (CDS) tools used to prioritize interventions. Methods The Medical University South Carolina (MUSC)...
and/or infrequently employed drug.
Empiric antibiotic treatment of serious and healthcare-associated pneumonia (PNA) often includes coverage methicillin-resistant Staphylococcus aureus (MRSA) Pseudomonas aeruginosa (PSA). Recent publications suggest that patients treated with the combination vancomycin (V) piperacillin–tazobactam (PT) have a greater risk acute kidney injury (AKI) than those V alone, or in another β-lactam, such as cefepime (C). There is paucity data regarding AKI other regimens provide MRSA PSA coverage,...
Abstract Background EC sequence type ST131 is the leading cause of extraintestinal infections, and accounts for most fluoroquinolone (FQ)-resistant extended-spectrum β-lactamase (ESBL)-producing clinical isolates. The ST131-H30 subclone (H30) responsible antimicrobial resistance within ST131; however, H30’s impact on outcomes poorly defined. We compared empiric treatment patterns patients with bacteriuria caused by vs. non-ST131 EC, H30 non-H30 strains. Methods Phylogroups, ST131, H30,...
Abstract Background Antibiotic treatment of asymptomatic bacteriuria (ASB) is considered inappropriate, does not improve patient outcomes, and may lead to adverse events such as antibiotic resistance Clostridioides difficile infection. Previous stewardship interventions have focused on reducing unnecessary urine culture collection in individuals without urinary symptoms; however, further reduce inappropriate prescribing ASB are warranted. This study sought identify characteristics associated...
In this retrospective cohort study, we evaluated the predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swabs for development MRSA infections in patients with left ventricular assist devices. 106 patients, swab had a negative 92.9% demonstrating potential role antibiotic de-escalation.
Introduction: The Surviving Sepsis Campaign guidelines recommend prompt intravenous antibiotic administration within one hour for patients with septic shock or a high likelihood of sepsis. To improve timeliness administration, piperacillin-tazobactam and cefepime were stocked in the automated dispensing cabinets (ADCs) five intensive care units (ICU).The aim this study was to evaluate time from order entry ICU before after addition ADC. Methods: This retrospective adult, presumed who...