Régis Souche
A5086161880- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Bariatric Surgery and Outcomes
- Inflammatory Bowel Disease
- Hernia repair and management
- Glioma Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Diverticular Disease and Complications
- Body Contouring and Surgery
- Liver Disease Diagnosis and Treatment
- Viral-associated cancers and disorders
- Colorectal Cancer Surgical Treatments
Centre Hospitalier Universitaire de Montpellier
2013-2025
Hôpital Saint Eloi
2015-2025
Université de Montpellier
2014-2025
Amsterdam University Medical Centers
2024
Cancer Center Amsterdam
2024
Institut de Recherche en Cancérologie de Montpellier
2015-2024
Inserm
2015-2024
University of Amsterdam
2024
Institut de Génétique Moléculaire de Montpellier
2021-2023
Institut Regional du Cancer de Montpellier
2021
Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open (ODP) in patients pancreatic ductal adenocarcinoma (PDAC). Background: Cohort studies have suggested superior short-term MIDP vs. ODP. Recent international surveys, however, revealed that surgeons concerns about the for PDAC. Methods: This is a pan-European propensity score matched including who underwent (laparoscopic or robot-assisted) ODP PDAC between...
Objectives The aim of this study was to compare endoscopic ultrasound‐guided choledochoduodenostomy (EUS‐CDS) vs. EUS‐gallbladder drainage (EUS‐GBD) in cases failed retrograde cholangiopancreatography (ERCP) for jaundice resulting from malignant distal biliary obstruction (MDBO). Methods This multicenter retrospective included patients with obstructive secondary MDBO who underwent EUS‐GBD or EUS‐CDS lumen‐apposing metal stents after ERCP. primary end‐point clinical success rate. Secondary...
We previously showed that embolization of portal inflow and hepatic vein (HV) outflow (liver venous deprivation, LVD) promotes future liver remnant (FLR) volume (FLR-V) function (FLR-F) gain. Here, we compared FLR-V FLR-F changes after (PVE) LVD.This study included all patients referred for preparation before major hepatectomy over 26 months. Exclusion criteria were: unavailable baseline/follow-up imaging, cirrhosis, Klatskin tumor, two-stage hepatectomy. 99mTc-mebrofenin SPECT-CT was...
Abstract Background The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study. Methods This retrospective study included all patients undergoing LLR 27 centres between 2000 and 2017. Cirrhosis defined as F4 fibrosis pathological examination. Short-term with without were compared propensity score matching by centre volume, demographic tumour characteristics, extent resection. Results Among 3150...
The relevance of laparoscopic resection intrahepatic cholangiocarcinoma (ICC) remains debated. aim this study was to compare (LLR) and open (OLR) liver for ICC, with specific focus on textbook outcome lymph node dissection (LND).Patients undergoing LLR or OLR ICC were included from two French, nationwide hepatopancreatobiliary surveys undertaken between 2000 2017. Patients negative margins, without transfusion, severe complications, prolonged hospital stay, readmission death considered have...
Stereotactic MR-guided adaptive radiotherapy (SMART) is an attractive modality of for pancreatic tumors. The objectives this prospective registry study were to report the dosimetric benefits daily adaptation SMART and first clinical results in tumors.All patients treated our center with a tumor included. Patients planned five daily-adapted fractions on consecutive days. Endpoints acute toxicities, late impact treatment target volume coverage organs at risk (OAR) sparing, local control (LC)...
The aim of this study was to assess recurrence risk factors following ileocolonic resection (ICR) for Crohn disease (CD) in a nationwide cohort SUMMARY BACKGROUND DATA:: Recurrence rate after ICR CD can be up 60%, but its predictive have never been evaluated large prospective studies.From 2013 2015, 346 consecutive patients undergoing and postoperative ileocoloscopy within 6 12 months surgery at 19 academic French centers were included prospectively.Twelve-month endoscopic (Rutgeerts score...
Introduction: Stereotactic MR-guided Adaptive RadioTherapy (SMART) is a novel process to treat pancreatic tumors. We present an update of the data from our prospective registry SMART for Materials and methods: After establishment indication in multidisciplinary board, we included all patients treated Primary endpoints were acute late toxicities. Secondary survival outcomes (local control, overall survival, distant metastasis free survival) dosimetric advantages adaptive on targets volumes...
Objective: Defining robust and standardized outcome references for distal pancreatectomy (DP) by using Benchmark analysis. Background: Outcomes after DP are recorded in medium or small-sized studies without Therefore, the best results remain uncertain. Methods: This multicenter study included all patients undergoing resectable benign malignant tumors 21 French expert centers pancreas surgery from 2014 to 2018. A low-risk cohort defined no significant comorbidities was analyzed establish 18...
Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions challenging and role endoscopic papillectomy has not been elucidated. We retrospectively analyzed outcomes in matched cohorts sporadic (SALs).This retrospective multicenter study included 1422 procedures. Propensity score matching including age, sex, comorbidity, histologic subtype, size was performed. Main were complete resection (R0),...
International guidelines recommend monitoring the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on distal pancreatectomy (MIDP) are lacking. This study examined robot-assisted (RDP) laparoscopic (LDP) in E-MIPS registry.
Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This multicentric retrospective cohort study of patients treated endoscopy or surgery for CoGNET. A literature review CoGNET was also performed. Fifteen were included, mostly female (n = 10) median age 50 years. Patients asymptomatic seven cases. Four pancreatoduodenectomy, four transduodenal...
Abstract Background and aims Postoperative recurrence requiring medical treatment intensification or redo surgery is common after ileocolic resection (ICR) for Crohn’s disease (CD). This study aimed to identify a subgroup of CD patients whom ICR could achieve durable remission. Methods retrospective follow-up analyzed 592 who underwent (2013-2015) in nationwide prospective cohort. Patients with >36 months were included. Primary outcome was remission, defined as the absence endoscopic...
To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery. Left-sided is associated worse OS right-sided cancer. Although currently seen as not effective RPC, current randomized trials included mostly RPC. International multicenter retrospective study including consecutive after resection for pathology-proven either or surgery 76 centers from 18 countries on 4 continents...
To identify risk factors for conversion, develop a predictive Conversion Risk Score (CRS), and assess the association between conversion severe postoperative complications. occurs in 15-30% of minimally invasive left pancreatectomies (MILP). potential negative impacts on outcomes are poorly described. Retrospective, nationwide, multicenter study including all MILP (laparoscopy robot) performed 2010 2021. were identified by multivariate mixed model, CRS was developed "training-set" validated...