A5035819939- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Fibroblast Growth Factor Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Retinal and Optic Conditions
- Renal cell carcinoma treatment
- Advanced Radiotherapy Techniques
- Plant Disease Resistance and Genetics
- Cerebral Venous Sinus Thrombosis
- Oral and Maxillofacial Pathology
- Sinusitis and nasal conditions
- Cancer Mechanisms and Therapy
- Transportation Systems and Logistics
- Lung Cancer Treatments and Mutations
- Histiocytic Disorders and Treatments
- Colorectal Cancer Treatments and Studies
- Ophthalmology and Visual Health Research
- Drug Transport and Resistance Mechanisms
University of Oklahoma Health Sciences Center
2025
The University of Texas MD Anderson Cancer Center
2016-2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Mayo Clinic in Arizona
2018
Assiut University
2018
Biliary tract cancers (BTCs) typically present at an advanced stage, and systemic chemotherapy is often of limited benefit.Hybrid capture-based comprehensive genomic profiling (CGP) was performed for 412 intrahepatic cholangiocarcinomas (IHCCAs), 57 extrahepatic (EHCCAs), 85 gallbladder carcinomas (GBCAs). The mutational profile correlated with the clinical outcome standard experimental therapies 321 patients. Clinical variables, detected mutations, administered were overall survival (OS) in...
FGFR genetic aberrations (GAs) occur in an estimated 10% to 16% of intrahepatic cholangiocarcinomas (CCAs). The natural history CCA with GAs, the prognostic role coexisting and outcome FGFR-targeted inhibitors are unknown.Patients GAs were identified using next-generation sequencing or fluorescence situ hybridization from four tertiary cancer centers compared wild-type counterparts. Data reviewed included demographic, treatment, overall survival (OS), GA data. Fisher's exact test,...
Biliary tract cancers (BTCs) are uncommon and associated with a dismal prognosis. Combinations of gemcitabine platinum chemotherapy (gemcitabine platinum-based therapy [GP]) form the standard approach for treating advanced BTC. To characterize spectrum mutations to identify potential biomarkers GP response in BTC, this study evaluated genomic landscape assessed whether affecting DNA repair were resistance.Pretreatment, formalin-fixed, paraffin-embedded samples from 183 BTC patients treated...
To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery. Left-sided is associated worse OS right-sided cancer. Although currently seen as not effective RPC, current randomized trials included mostly RPC. International multicenter retrospective study including consecutive after resection for pathology-proven either or surgery 76 centers from 18 countries on 4 continents...
BRCA-associated protein 1, an enzyme encoded by the BAP1 gene, is commonly mutated in uveal melanoma, mesothelioma, and renal cancers. Tumors with mutation follow aggressive course. mutations have also been observed cholangiocarcinoma (CCA). The clinical phenotype of mutant CCA may yield useful prognostic therapeutic information but has not defined.The records patients who underwent next-generation sequencing (NGS) were reviewed, data on clinical, histopathological, genetic, radiological...
PURPOSE Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes this population. However, cholangiocarcinoma (CCA), a paucity data exist on AYA To our knowledge, we present largest study date disease biology, treatment patterns, survival CCA. METHODS A multi-institutional cohort patients CCA diagnosed intrahepatic (ICC) or extrahepatic (ECC) was used analysis. Retrospective chart review conducted who were 50...
Gallbladder cancer (GBC) is an aggressive malignancy. Although surgical resection may be curable, most patients are diagnosed at advanced unresectable disease stage. Cholelithiasis the major risk factor; however pathogenesis of disease, from gallstone cholecystitis to cancer, still not understood. To understand molecular genetic underpinnings this and explore novel therapeutic targets for GBC, we examined key genes pathways involved in GBC using RNA sequencing. We performed gene expression...
4079 Background: BTC are uncommon and associated with a dismal prognosis. Gemcitabine platinum-combinations (GP) form the standard approach for treating advanced modest improvement in survival. To identify potential biomarkers response to GP BTC, we used NGS evaluate genomic landscape whether mutations affecting DNA repair were resistance. Methods: Pretreatment formalin-fixed, paraffin-embedded (FFPE) samples from 183 patients (pts) treated analyzed commercial targeted platform. Genes...
4076 Background: Gallbladder carcinoma (GBC) is commonly diagnosed at an advanced, unresectable disease stage and has a poor prognosis. Comprehensive genomic profiling (CGP) developing role in guiding systemic, precision anti-cancer therapy. Methods: We performed hybrid capture-based CGP on FFPE samples for 491 consecutive advanced GBCs. Mean coverage depth was >550X up to 315 cancer-related genes plus 37 introns from 28 frequently rearranged cancer. All 4 classes of alterations (GA) were...
4086 Background: Mutations in DNA repair pathway were identified 13% of Biliary Tract Cancers (BTC) [ Cancer2016;122:3838–3847]. High TMB tumors including melanoma, lung cancer and those with microsatellite instability (MSI-H) are associated susceptibility to immune blockade using checkpoint inhibitors. data BTC is limited its association actionable somatic mutation (mut) profiles unknown. Methods: Comprehensive genomic profiling (CGP) 309 FFPE tissue blocks pts a hybrid capture all coding...
109 Background: FGFR pathway genetic aberrations (GAs) occur in an estimated 10% of intrahepatic cholangiocarcinomas (IHCCA). The most common are FGFR2 mutations (mut). advent targeted inhibitors may alter the outcome this disease subtype. natural history mutant CCA and prognostic role co-existing mut is unknown. Methods: We reviewed records patients (pts) with GAs identified on next generation sequencing (NGS). Data included demographics, treatments, progression-free survival (PFS)...
428 Background: Acute cholangitis due to malignant biliary obstruction is frequent in patients with pancreatic and hepatobiliary cancers. Recurrent (RC) results repeated hospitalization delayed cancer care. The risk factors associated RC are not yet defined. Methods: A pilot review was done on 146 admitted a diagnosis of from 2005 2014. We included demographics, stage, details first admission (FA) interventions. Univariate multivariate Fine-Gray models were used for statistical analysis....
244 Background: Biliary tract cancers (BTC) exhibit a diverse and high frequency of actionable mutations detectable using next generation sequencing (NGS). The Breast Cancer Linkage Consortium reported that BRCA2 mutation carriers are at increased risk for BTC with estimated relative 4.97, (95% CI = 1. 50-16.52). purpose this study was to evaluate the clinical characteristics germline/somatic BRCA1/2mutations in CCA patients. Methods: Multi-center retrospective analysis patients BRCA1/2-...
287 Background: aBTC is uncommon and has a dismal prognosis with limited therapeutic options. First-line therapy for untreated GC, no approved therapies in the refractory setting. To assess tumor-specific genetic variants that affect outcomes patients (pts) who received GC aBTC, we performed NGS pts treated as first-line therapy. Methods: Archival formalin-fixed, paraffin-embedded samples from mBTC Ohio State University MD Anderson Cancer Center underwent part of routine care. 315...
240 Background: As seen in lung cancer, young patients with cancer can have different risk factors, presentation, and tumor genotype than older the same disease. The clinical molecular features of CCA yet to be well characterized. Methods: Retrospective chart review was performed on intrahepatic (ICC) or extrahepatic cholangiocarcinoma (ECC) across 5 institutions. Data demographics, treatments, pathology, overall survival (OS) were collected. Tumor genotyping results from MGH SNaPShot...
Purpose -To study the clinical profile of patients panophthalmitis presenting to tertiary health care centre. Methods-This was a prospective observational that involved25 with complaining blurring vision, redness, pain, purulent discharge, photophobia and eyelid swelling. Results-There were 18 males 7 females age group taken 30 75 years.14 belonged 45 years, out which 10 4 females. 46 60 5 2 61 3 1 female. Most common presentation in is loss vision 88% followed by redness 76% patients, pain...
Purpose:To study fundus findings in patients of mild,moderate, and severe degree anaemia presenting to the tertiary health care centre. Methods:This was a prospective observational that involved25 anemiacomplaining blurring vision, conjunctival pallor, pain, subconjunctival hemorrhage eyelid swelling. Results:There were 20females 5 males age group taken 20 50 years.Out 25 nutritional anemia, 12 belonged 30 years, out which 10 females 2 weremales. 8 40 6 males. 4 1 male.In our study, it found...