Thomas F. Stoop
A5045757906- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Central Venous Catheters and Hemodialysis
- Bariatric Surgery and Outcomes
- COVID-19 and healthcare impacts
- Surgical Simulation and Training
- Cancer Diagnosis and Treatment
- Vascular anomalies and interventions
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Healthcare cost, quality, practices
- Colorectal and Anal Carcinomas
- Congenital gastrointestinal and neural anomalies
- Chronic Disease Management Strategies
- MRI in cancer diagnosis
University of Amsterdam
2018-2025
Amsterdam University Medical Centers
2019-2025
Cancer Center Amsterdam
2020-2025
University of Colorado Anschutz Medical Campus
2020-2025
Karolinska University Hospital
2020-2025
Karolinska Institutet
2020-2025
University of Colorado Denver
2024-2025
Emma Kinderziekenhuis
2023
Amsterdam UMC Location University of Amsterdam
2018
Vrije Universiteit Amsterdam
2012
PURPOSE Previous studies suggest that besides anatomy (A: resectable, borderline resectable [BR], or locally advanced [LA]) also biologic (B: carbohydrate antigen 19-9 [CA 19-9]) and conditional (C: performance status) factors should be considered when staging patients with localized pancreatic ductal adenocarcinoma (PDAC). The prognostic value of the combined ABC has not been quantitatively validated. METHODS In this retrospective cohort study, we evaluated PDAC treated initial (modified)...
Importance Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) a small subset of patients. However, multicenter studies in-depth data about pCR are lacking. Objective To investigate the incidence, outcome, and risk factors after preoperative chemo(radio)therapy. Design, Setting, Participants This observational, international, cohort study assessed all consecutive pathology-proven...
To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with vein (PMV) involvement. Current comparative studies on PVR as part of include all degrees PMV involvement, including cases where may not be a feasible approach, limiting the clinical applicability. International retrospective study 10 centers from 5 countries, consecutive after ≤180°...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
To investigate complications and survival following surgical resection for pancreatic cancer with arterial encasement. Surgery extensive involvement (encasement) of the major visceral arteries remains a topic debate due to concerns regarding morbidity, mortality, uncertain oncological benefit. Pancreatic patients encasement superior mesenteric artery (SMA), hepatic (HA), and/or celiac (CA) at baseline imaging who underwent after neoadjuvant therapy University Colorado Hospital between...
Objective: The aim of this study was to establish clinically relevant outcome benchmark values using criteria for pancreatoduodenectomy (PD) with portomesenteric venous resection (PVR) from a low-risk cohort managed in high-volume centers. Summary Background Data: PD PVR is regarded as the standard care patients cancer involvement axis. There are, however, no indicators population which hampers comparisons undergoing and without resection. Methods: This multicenter analyzed any type 23...
Objective: The aim of this study was to clarify the role pancreatic surgery during COVID-19 pandemic optimize patients’ and clinicians’ safety safeguard health care capacity. Summary Background Data: heavily impacts systems worldwide. Cancer patients appear have an increased risk for adverse events when infected by COVID-19, but inability receive oncological seems may be even larger threat, particularly in case cancer. Methods: An online survey submitted all members seven international...
Abstract Background Surgery in selected patients with locally advanced pancreatic cancer after induction chemotherapy may have drawbacks related to surgical risks and breaks or delays oncological treatment, particular when curative intent resection is not possible (that non-therapeutic laparotomy). The aim of this study was assess the incidence impact a laparotomy treated (m)FOLFIRINOX chemotherapy. Methods This retrospective international multicentre including diagnosed pathology-proven at...
Histopathologically scoring the response of pancreatic ductal adenocarcinoma (PDAC) to neoadjuvant treatment can guide selection adjuvant therapy and improve prognostic stratification. However, several tumor (TRS) systems exist, consensus is lacking as which system represents best practice. An international meeting on TRS took place in November 2019 Amsterdam, The Netherlands. Here, we provide an overview outcomes statements that originated from this meeting. Consensus (≥80% agreement) was...
Total pancreatectomy (TP) is mentioned as alternative to pancreatoduodenectomy (PD) with high-risk pancreatojejunostomy (PJ) avoid severe pancreatic fistula-related complications, but its benefit controversial and comparative studies are scarce.Cross-sectional single-center study among patients after PD PJ versus single-stage elective TP for any indication (2015-2017), using propensity scores evaluate surgical outcomes long-term quality of life (QoL) in three risk strata. EORTC QLQ-C30...
Objective: The aim of this study was to evaluate whether neoadjuvant therapy (NAT) critically influenced microscopically complete resection (R0) rates and long-term outcomes for patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy (PD) portomesenteric vein (PVR) from a diverse, world-wide group high-volume centers. Summary Background Data: Limited size studies suggest that NAT improves R0 overall survival compared upfront surgery in R/BR-PDAC patients. Methods:...
Aim: To investigate the impact of total pancreatectomy (TP) on oncological outcomes for patients at high-risk local recurrence or secondary progression in remnant gland after partial (PP) IPMN-associated cancer. Summary Background Data: Major risk factors invasive include multifocality, diffuse main duct dilation, and presence In these patients, a TP may be oncologically beneficial. However, current guidelines discourage TP, especially elderly patients. Methods: This international...
Abstract Background Nationwide audits facilitate quality and outcome assessment of pancreatoduodenectomy. Differences may exist between countries but studies comparing nationwide outcomes pancreatoduodenectomy based on are lacking. This study aimed to compare the German Dutch for external data validation. Methods Anonymized from patients undergoing 2014 2016 were extracted Society General Visceral Surgery StuDoQ|Pancreas Pancreatic Cancer Audit, compared using descriptive statistics....
To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery. Left-sided is associated worse OS right-sided cancer. Although currently seen as not effective RPC, current randomized trials included mostly RPC. International multicenter retrospective study including consecutive after resection for pathology-proven either or surgery 76 centers from 18 countries on 4 continents...
To validate the prognostic value of PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX. The PANAMA-score was developed guide prognostication therapy PDAC. As this score focuses on risk residual disease resection, it might also be able select who therapy. This retrospective international multicenter...
Objective: The aim of the study was to investigate prognostic factors in context neoadjuvant therapy (NAT) and develop tools that can allow for accurate personalized patient prognostication. Summary Background Data: NAT might impact ability well-established clinicopathological resected pancreatic ductal adenocarcinoma (PDAC). Methods: Patients after resection PDAC were identified from Dutch Pancreatic Cancer Group Recurrence Database institutional databases at NYU Langone Health Johns...