A5037848161- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Airway Management and Intubation Techniques
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Steroid Chemistry and Biochemistry
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Image and Object Detection Techniques
- Autonomous Vehicle Technology and Safety
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Robotics and Sensor-Based Localization
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Video Surveillance and Tracking Methods
- Respiratory Support and Mechanisms
- Colorectal and Anal Carcinomas
- Vehicle License Plate Recognition
- Tracheal and airway disorders
University of Colorado Anschutz Medical Campus
2025
Kitamurayama Hospital
2025
Kurihama Medical and Addiction Center
2025
University of Colorado Denver
2024-2025
Institute of Science Tokyo
2024-2025
Shanghai Institute for Science of Science
2025
Toppan (United Kingdom)
2024
Keio University
1997-2023
Saitama Cancer Center
2021-2023
Tokyo Medical and Dental University
2022-2023
ABSTRACT The development and validation of a one-step, real-time, quantitative dengue virus serotype-specific reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay targeting the 3′ noncoding region for rapid detection differentiation serotypes are reported. RT-LAMP is very simple rapid, wherein can be obtained in 30 min under conditions at 63°C by employing set four primer mixtures through real-time monitoring an inexpensive turbidimeter. evaluation use clinical...
Background and Purpose —To investigate relationships among plaque formation, increasing intima-media thickness, age, we examined ultrasonographically carotid arteries of subjects who had no major atherosclerotic risk factors ranged in age from young adults to centenarians. Methods —We studied 319 healthy (154 men, 165 women; range, 21 105 years) with history hypertension, diabetes mellitus, or disease. Mean wall thickness (IMT) common at plaque-free sites prevalence plaques were evaluated by...
mRNA synthesized by transcription in vitro of the cloned cDNA encoding rat brain sodium channel III directs formation a functional Xenopus oocytes. The tissue distribution mRNAs channels I, II and has been studied blot hybridization analysis with specific probes.
To investigate complications and survival following surgical resection for pancreatic cancer with arterial encasement. Surgery extensive involvement (encasement) of the major visceral arteries remains a topic debate due to concerns regarding morbidity, mortality, uncertain oncological benefit. Pancreatic patients encasement superior mesenteric artery (SMA), hepatic (HA), and/or celiac (CA) at baseline imaging who underwent after neoadjuvant therapy University Colorado Hospital between...
Abstract The aim of this study was to investigate the mechanism inhibition Eg5 (kinesin spindle protein), a mitotic kinesin that plays an essential role in establishing bipolarity, by novel small molecule inhibitor K858. K858 selected phenotype-based forward chemical genetics screen as antimitotic agent, and subsequently characterized Eg5. blocked centrosome separation, activated checkpoint, induced arrest cells accompanied formation monopolar spindles. Long-term continuous treatment cancer...
Background: The orbital blowout fracture is a common facial injury, but full consensus has not been reached regarding its optimal management. authors retrospectively explored consecutive cases of fractures and proposed new recommendations for treatment. Methods: Two hundred eight newly registered patients were selected from the database Nagasaki University Hospital over past 5 years. One nine in authors' department then reviewed computed tomographic classification types, preoperative...
In the course of our search for new antitumor agents in breast cancer, novel amino-substituted flavone derivatives were synthesized and examined activities. Among them, 5,4'-diaminoflavone some its congeners showed remarkable antiproliferative activity against estrogen receptor (ER)-positive estrogen-responsive human cancer cell line MCF-7. The was observed irrespective presence or absence estrogen. 5-aminoflavone (5-AFs) are not classical anti-estrogens because they did compete with...
Estrogen receptor (ER) plays an important role in various physiological functions. We examined whether ERα and ERβ are expressed squamous cell carcinoma (SCC), ER is a potential target for antitumor therapy. High‐level expression of ERβ, but not ERα, was observed tumor cells human primary SCC tissues cultured lines. Treatment with antagonist (tamoxifen), agonist (estradiol), caused apoptotic death concentration‐ time‐dependent manner. Adhesion inhibited by the treatment tamoxifen, estradiol....
Abstract Background Mental health problems during pregnancy are multifaceted major issues. Aim To develop and validate a short screening questionnaire that covers important domains including antenatal depression, tokophobia, fetal bonding disorder, suicidality, emesis. Methods A total of 321 pregnant women who were less than 36 weeks gestation responded to cross‐sectional web survey filled in the 33‐item Dimensional Assessment Mother Baby Organization Questionnaire (DAMBO Q33, available as...
Recently, we reported that 5,4'-diaminoflavone (1) exhibits potent and specific growth-inhibitory activity against the estrogen receptor (ER)-positive human breast cancer cell line MCF-7. However, when compound 1 was incubated with S-9 mix, its metabolites were observed. Moreover, addition of mix to medium caused drastic decrease in 1. Since 6-, 8-, 3'-positions considered be metabolized oxidatively vivo from MO calculations, a series derivatives substituted at such putative metabolic...
To investigate the incidence and risk factors of portomesenteric venous thrombosis (PVT) after pancreatic cancer surgery with resection (PVR).
Recently, we reported that 5,4'-diamino-6,8,3'-trifluoroflavone (1b) exhibits potent antitumor activity against certain types of human cancer cell lines both in vitro and vivo. Since the antiproliferative 5,4'-diaminoflavone (1a), lead compound 1b, was modulated by addition apigenin, hypothesized 7-position is important for interaction with a putative target molecule. On basis this hypothesis, structure−activity relationships substituents at 1b were explored. As result, 7-methyl (7a),...