A5110807984- Underwater Acoustics Research
- Underwater Vehicles and Communication Systems
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- earthquake and tectonic studies
- Maritime Navigation and Safety
- Cardiac, Anesthesia and Surgical Outcomes
- Methane Hydrates and Related Phenomena
- Water Quality Monitoring Technologies
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Geophysical Methods and Applications
- Intensive Care Unit Cognitive Disorders
- Fish Ecology and Management Studies
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Homotopy and Cohomology in Algebraic Topology
- Seismic Waves and Analysis
- GNSS positioning and interference
- Geochemistry and Elemental Analysis
- Veterinary Pharmacology and Anesthesia
- Pharmacogenetics and Drug Metabolism
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Advanced Topics in Algebra
- Respiratory Support and Mechanisms
Kobe University
2025
Texas A&M University at Galveston
2021
The University of Tokyo
2010-2020
Osaka Institute of Technology
2019
Japan Society for the Promotion of Science
2018
Nagoya Institute of Technology
2018
Texas Tech University
2018
Tokyo University of Science
2005-2016
Advanced Institute of Industrial Technology
2000-2016
Inspiration Innovation Synergy University
2016
The moment magnitude (M(w)) = 9.0 2011 Tohoku-Oki mega-thrust earthquake occurred off the coast of northeastern Japan. Combining Global Positioning System (GPS) and acoustic data, we detected very large sea-floor movements associated with this event directly above focal region. An area more than 20 meters horizontal displacement, that is, four times larger those on land, stretches several tens kilometers long along trench; largest amount reaches about 24 toward east-southeast just...
Background — Cigarette smoking is a well-known risk factor for the development of cardiovascular disease, yet mechanism action involved not completely understood. Because cigarette smoke contains superoxide and other reactive oxygen species, it has been hypothesized that some adverse effects may result from oxidative damage to endothelial cells, which results in nitric oxide (NO) shortage. However, little information available regarding acute on plasma concentrations NO antioxidants. We...
Abstract We have been developing a system for detecting seafloor crustal movement by combining kinematic GPS and acoustic ranging techniques. A linear inversion method is adopted to determine the position of stations from coordinates moving survey vessel measured travel times waves in seawater. The positioning accuracy substantially improved estimating temporal variation velocity structure. apply our data acquired at reference point, MYGI, located off Miyagi Prefecture, northeast Japan,...
Although it is widely used, the mechanisms and effects of acupuncture on pain are not completely understood. Recently, increased nitric oxide (NO) synthase activity has been found in meridians acupoints. Because NO a key regulator local circulation, because change circulation can affect development persistence pain, we propose that might regulate levels. We studied levels randomized, double-blind, crossover study with 20 volunteers, each whom underwent one session real noninvasive sham...
Abstract The GPS/acoustic seafloor positioning has detected significant postseismic movements after the 2011 Tohoku‐Oki earthquake ( M 9.0), just above source region off Pacific coast of eastern Japan. In contrast to coastal Global Navigation Satellite Systems sites where trenchward‐upward were reported, offshore main rupture zone in northern part exhibit landward displacements tens centimeters with subsidence from almost 3 years repeated observations. At around edge zone, smaller amount...
We studied the effects of highly purified bone morphogenetic protein 2 and 3 (BMP-2 -3) on growth plate chondrocytes osteoblastic cells in vitro compared to TGF-beta. A mixture BMP-2 (BMPs) strongly stimulated DNA synthesis presence fibroblast factor (FGF). BMPs induced rapid maturation at a growing stage: transformed into rounded marked accumulation cartilage matrix; TGF-beta slightly reduced matrix changed cell morphology spindle-like FGF. Moreover, exposure resulted dramatic increase...
The metabolism of lidocaine by human hepatic microsomes and purified cytochrome P-450s, P-450NF (P450IIIA4), P-450MP (a P450IIC form) P-450PA (P450IA2) was examined their compared with that rat P-450s. Human produced monoethylglycinexylidide (MEGX) 3-hydroxylidocaine (3-OH-LID) from lidocaine. In a reconstituted system dilauroylphosphatidylcholine, efficiently MEGX. not efficient in N-deethylation (formation MEGX) but 3-OH-LID. did produce Lidocaine activity enhanced modified phospholipid...
Indian Ocean hydrothermal vents are believed to represent a novel biogeographic province, and host many genera families of animals, potentially indigenous systems. In particular, since its discovery in 2001, much attention has been paid so-called 'scaly-foot' gastropod because unique iron-sulfide-coated dermal sclerites the chemosynthetic symbioses various tissues. Despite increasing interest faunal assemblages at vents, only two vent fields have investigated Ocean. Here we report newly...
α2-Adrenoceptors are widely distributed throughout the central nervous system (CNS) and systemic administration of α2-agonists such as dexmedetomidine produces clinically useful, centrally mediated sedation analgesia; however, these same actions also limit utility agents (ie, unwanted sedative actions). Despite a wealth data on cellular synaptic in vitro, it is not known which neuronal circuits modulated vivo to produce analgesic effect. To address this issue, we made recordings membrane...
alpha-Tocopherol is a potent antioxidant that effectively protects biological membranes against oxidative injury through coordination with ascorbic acid. Because propofol has phenolic structure similar to of alpha-tocopherol, this intravenous anesthetic may also have activity. To test hypothesis, the effect on human erythrocytes was examined. Propofol inhibited hemolysis and cis-parinaric acid oxidation in erythrocyte (ED(50) = 6 microM). Although alone no appreciable effect, protective...
The involvement of reactive oxygen species early in the development surgical stress and injury is highly suspected but has not been confirmed. Medical approaches to manage this type oxidative are unknown.We measured levels blood hydroperoxides as an index cellular components, well plasma ferric-reducing ability total antioxidant potential, during sigmoidectomy under four conditions: open with sevoflurane anesthesia, laparoscopic propofol anesthesia.Ferric-reducing decreased significantly...
To determine the cytochrome P450 (CYP) isoforms involved in oxidation of propofol by human liver microsomes.The rate constant calculated from disappearance an incubation mixture with microsomes and recombinant CYP was used as a measure metabolism propofol. The correlation these constants rates isoform-selective substrates microsomes, effect chemical inhibitors monoclonal antibodies on its were examined.The mean obtained six individuals 4.2 (95% confidence intervals 2.7, 5.7) nmol min(-1)...
Propofol and midazolam are commonly used as sedatives for critically ill patients. These patients usually suffer from the pathologic effects of oxidative stress, predominantly caused by an imbalance between generation reactive oxygen species antioxidant defense system. Therefore, activities propofol may be clinical importance. We investigated these two against hydrophilic or lipophilic peroxyl radicals in a homogeneous solution presence erythrocyte membranes. A chemical analysis revealed...
Background: The pleth variability index (PVI) is a new algorithm used for automatic estimation of respiratory variations in pulse oximeter waveform amplitude, which might predict fluid responsiveness. Because anesthesia‐induced hypotension may be partly related to patient volume status, we speculated that pre‐anesthesia PVI would able identify high‐risk patients significant blood pressure decrease during anesthesia induction. Methods: We measured the PVI, heart rate (HR), systolic (SBP),...
Changes in polyamine metabolism during growth-stimulation of mouse salivary glands by isoproterenol were investigated. In parotid gland, the activity ornithine decarboxylase [EC 4.1.1.17] increased very rapidly after administration drug and reached a maximum 8 hr. The maximal enzyme was about 40-fold higher than that unstimulated gland. Thereafter decreased abruptly returned to normal 20 putrescine-dependent S-adenosyl-L-methionine 4.1.1.50] also this treatment 12 hr, peak being 7-fold...
Abstract Seafloor crustal movements off Miyagi and Fukushima Prefectures, northeastern Japan, observed for about 9 years before the 2011 Tohoku‐oki earthquake ( M 9.0) with GPS/acoustic geodetic technique, revealed spatiotemporal variation of interplate coupling in this region. Off Prefecture, temporal variations are characterized as a strain accumulation‐release process relation to 2005 Miyagi‐oki 7.2). The intraplate velocity since December 2006, when accumulation seemed have restarted, is...
Background Ropivacaine is a local anesthetic with long duration of action. Although it less toxic than bupivacaine, toxicity possible when the plasma concentration increased. Because ropivacaine an amide-type anesthetic, metabolized by cytochrome P450 (P450) in liver, and its elimination can be dependent on level P450. The purpose this investigation was to elucidate metabolism human hepatic Methods compared using recombinant purified rat isozymes. An inhibition study antibodies against...
Background: Apoptosis (programmed cell death) occurs in various physiological and pathological conditions, exhibits a characteristic mechanism of intracellular sequential reaction may be involved determining clinical outcome. The antioxidant activity propofol (2,6‐diisopropylphenol) together with the stimulating effect protein kinase C suggests that might have potential to modulate apoptosis. Thus, it is both interest biomedical importance investigate clarify upon reactions underlying...