Katia Lécolle
A5087973907- COVID-19 and healthcare impacts
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Alzheimer's disease research and treatments
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Virus-based gene therapy research
- Respiratory Support and Mechanisms
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Nerve injury and regeneration
- Frailty in Older Adults
- Ultrasound in Clinical Applications
- Radiation Dose and Imaging
- Healthcare cost, quality, practices
- Lung Cancer Research Studies
- RNA regulation and disease
Hôpital Claude Huriez
2018-2024
Centre Hospitalier Universitaire de Besançon
2024
Assistance Publique – Hôpitaux de Paris
2024
Sorbonne Paris Cité
2024
Université Paris Cité
2020-2024
Institut national de recherche en informatique et en automatique
2024
Hôpital Cochin
2024
Centre Hospitalier Universitaire de Lille
2021-2024
Université de Lille
2009-2024
All India Institute of Medical Sciences Rishikesh
2022
In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. human brain, hierarchical pathways this neurodegeneration have been well established in Alzheimer’s disease (AD) and other tauopathies such as argyrophilic grain disorder progressive supranuclear palsy but molecular cellular mechanisms supporting progression are yet not known. These appear to be associated with intercellular transmission pathology, recently...
Objective: To compare 2 techniques of remnant liver hypertrophy in candidates for extended hepatectomy: radiological simultaneous portal vein embolization and hepatic (HVE); namely LVD, ALPPS. Background: Recent advances chemotherapy surgical have widened indications hepatectomy, before which augmentation is mandatory. ALPPS LVD typically show higher rates than embolization, but their respective places patient management remain unclear. Methods: All consecutive procedures performed 8 French...
Abstract Background The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study. Methods This retrospective study included all patients undergoing LLR 27 centres between 2000 and 2017. Cirrhosis defined as F4 fibrosis pathological examination. Short-term with without were compared propensity score matching by centre volume, demographic tumour characteristics, extent resection. Results Among 3150...
The relevance of laparoscopic resection intrahepatic cholangiocarcinoma (ICC) remains debated. aim this study was to compare (LLR) and open (OLR) liver for ICC, with specific focus on textbook outcome lymph node dissection (LND).Patients undergoing LLR or OLR ICC were included from two French, nationwide hepatopancreatobiliary surveys undertaken between 2000 2017. Patients negative margins, without transfusion, severe complications, prolonged hospital stay, readmission death considered have...
To evaluate the prevalence of sarcopenia in patients undergoing pancreatic surgery and to examine its impact on surgical outcomes survival patients. Skeletal muscle index (SMI) was measured preoperative CT. A patient considered sarcopenic if SMI <38.5 cm2/m2 for a female or <52.4 male. Postoperative fistula (POPF) severe morbidity (Clavien≥3) were analyzed. Survival with cancer calculated using Kaplan–Meier method. In total, 107 consecutive included. Among them, 50 (47%) 65 (60%)...
Most models for tauopathy use a mutated form of the Tau gene, MAPT, that is found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and leads rapid neurofibrillary degeneration (NFD). Use wild-type (WT) human protein model aggregation associated neurodegenerative processes mouse brain has thus far been unsuccessful. In present study, we generated an original "sporadic tauopathy-like" rat hippocampus, encoding six isoforms as humans, using lentiviral vectors (LVs)...
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant (FRL). Nevertheless, high morbidity mortality rates have been reported. In this setting, including hepatobiliary scintigraphy in the clinical surgical management of offered ALPPS advocated both assess eligibility stagel suitable time stage2. Recently, it was stated that partial...
Abstract Tumor cells can escape the immune system by overexpressing molecules of B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses anti-tumor T-cell responses through binding to PD-1 receptor, and similarly for B7.1 (CD80), CTLA-4. Moreover, direct interactions between are also likely participate in immunoevasion mechanism. In this study, we used a mouse model tumor dormancy, DA1-3b leukemia cells. We previously showed that minor population persists equilibrium with long periods time,...
Tauopathies represent a heterogeneous group of neurodegenerative diseases characterized by the intracellular accumulation aggregated tau proteins in neurons, glia, or both. Currently, animal models tauopathies mainly include transgenic overexpressing with FTDP-17 mutations. Neurofibrillary degeneration is slow process starting people under 30 years old. One can ask if mutated really reflects this since mutations enhance aggregation rate proteins. These are found less than 1 % raising...
Tauopathies represent a heterogeneous group of neurodegenerative diseases characterized by the intracellular accumulation Tau, which results in neurofibrillary degeneration (NFD). In sporadic forms tauopathies, such as Alzheimer's disease, argyrophilic grain disease and progressive supranuclear palsy, wild-type (WT) Tau progressively aggregates affects brain regions following spatio-temporal pathway. mice, it is difficult to reflect this spreading, since variants bearing FTDP-17 mutation are...