Jacques Ewald
A5101774800- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Central Venous Catheters and Hemodialysis
- Foreign Body Medical Cases
- Organ Donation and Transplantation
Institut Paoli-Calmettes
2016-2025
Aix-Marseille Université
2014-2023
Institut Pprime
2014-2022
Pitié-Salpêtrière Hospital
2021
Hôpitaux Universitaires Henri-Mondor
2021
Assistance Publique – Hôpitaux de Paris
2021
Simplification des soins chez les patients complexes
2020-2021
Université de Picardie Jules Verne
2021
Sorbonne Université
2007-2021
Inserm
2007-2021
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These uncovered specific alterations DNA...
In Brief Introduction: pancreatic adenocarcinoma (PA), a margin negative resection (R0) is critical for long-term survival. Background: Although pancreaticoduodenectomy (PD) with en-bloc portal vein/superior mesenteric vein (PV/SMV) used in patients venous involvement by tumor, its utility no unknown. This study examines survival who had PD PV/SMV resection. Methods: From 2000 to 2010, 34 resectable PA on preoperative staging. Fifteen (44%) histological and 19 (56%) (–PV/SMV group). We...
Abstract Background The aim was to analyse the impact of cirrhosis on short-term outcomes after laparoscopic liver resection (LLR) in a multicentre national cohort study. Methods This retrospective study included all patients undergoing LLR 27 centres between 2000 and 2017. Cirrhosis defined as F4 fibrosis pathological examination. Short-term with without were compared propensity score matching by centre volume, demographic tumour characteristics, extent resection. Results Among 3150...
The relevance of laparoscopic resection intrahepatic cholangiocarcinoma (ICC) remains debated. aim this study was to compare (LLR) and open (OLR) liver for ICC, with specific focus on textbook outcome lymph node dissection (LND).Patients undergoing LLR or OLR ICC were included from two French, nationwide hepatopancreatobiliary surveys undertaken between 2000 2017. Patients negative margins, without transfusion, severe complications, prolonged hospital stay, readmission death considered have...
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) represents an option to treat obstructive jaundice when endoscopic retrograde cholangiopancreatography (ERCP) fails. The success rate of this procedure has been shown be very high. Up now, plastic and self-expandable metallic stents (SEMSs) have employed, each them presenting some limitations. aims study were evaluate the technical functional rates EUS-HGS using a dedicated biliary SEMS with half-covered part (Giobor® stent).We...
Introduction: The optimal treatment for small, asymptomatic, nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNEN) is still controversial. European Neuroendocrine Tumor Society (ENETS) guidelines recommend a watchful strategy asymptomatic NF-PanNEN <2 cm of diameter. Several retrospective series demonstrated that non-operative management safe and feasible, but no prospective studies are available. Aim the ASPEN study to evaluate ≤2 comparing active surveillance surgery....
Objective: To establish a novel method for evaluating carbohydrate antigen 19-9 (CA19-9) during neoadjuvant therapy (NAT) and assess its role in predicting overall (OS) disease-free (DFS) survival borderline resectable pancreatic adenocarcinoma (BR-PC). Summary Background Data: Static CA19-9 values or percentage changes often fail to capture therapeutic responses patients with BR-PC undergoing NAT. Improved evaluation methods are essential guiding the treatment. Methods: This was...
// Odile Gayet 1 , Celine Loncle Pauline Duconseil Marine Gilabert Maria Belen Lopez Vincent Moutardier 1, 2 Olivier Turrini 3 Ezequiel Calvo 4 Jacques Ewald Marc Giovannini Mohamed Gasmi 5 Erwan Bories Barthet Mehdi Ouaissi 6 Anthony Goncalves Flora Poizat Jean Luc Raoul Veronique Secq Stephane Garcia Patrice Viens Nelson Dusetti Juan Iovanna Centre de Recherche en Cancérologie Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut...
To determine predictive factors of postoperative pancreatic fistula (POPF) in patients undergoing enucleation (EN). From 2005 to 2017, 47 underwent EN and had magnetic resonance imaging available for precise analysis tumor location. Three zones were delimited by the right side portal vein main head duct (zone #3 comprising lower parenchyma uncinate process). The mortality morbidity rates 0% 62%, respectively. POPF occurred 23 (49%) was graded as B or C (severe) 15 (32%). Four (8.5%)...