A5083466293- Acute Myeloid Leukemia Research
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Endometrial and Cervical Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Acute Lymphoblastic Leukemia research
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Gallbladder and Bile Duct Disorders
- Chronic Myeloid Leukemia Treatments
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Management of metastatic bone disease
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gene expression and cancer classification
- Breast Lesions and Carcinomas
- Colorectal Cancer Screening and Detection
- CAR-T cell therapy research
- Gastrointestinal Tumor Research and Treatment
- Advanced Breast Cancer Therapies
Institut Paoli-Calmettes
2015-2024
Institut de Recherche pour le Développement
2017-2023
Economic & Social Sciences, Health Systems & Medical Informatics
2017-2023
Aix-Marseille Université
2017-2023
Inserm
2006-2023
UniCancer Group
2021
Institut de Cancérologie Strasbourg
2021
Centre Jean Perrin
2021
Centre Oscar Lambret
2021
Centre Eugène Marquis
2021
Abstract Background Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic prognostic information lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 20q13 are recurrently amplified breast cancers. Methods To assess the frequencies clinical impact of amplifications, we analyzed 547 invasive tumors organized a tissue microarray (TMA) by fluorescence situ hybridization (FISH) calculated correlations with...
Objective Colony‐stimulating factor 1 receptor (CSF‐1R) essentially modulates monocyte proliferation, migration, and activation, which are considered important for the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine CSF‐1R expression in human RA as well efficacy a specific anti–CSF‐1R monoclonal antibody (AFS98) 2 different animal models RA. Methods was examined blood, synovium, bone samples from patients, osteoarthritis (OA) healthy subjects. The AFS98 by...
Over the last two decades, EUS-guided hepaticogastrostomy (EUS-HGS) has emerged as a therapeutic alternative for patients with biliary obstruction and failed ERCP. Percutaneous transhepatic drainage (PTBD) gold standard is associated relevant morbidity need re-intervention. The aim of our work was to evaluate in phase II study safety efficacy profile EUS-HGS. A PTBD arm considered control group.We conducted prospective, randomized, noncomparative three French tertiary centers involving...
DNA microarray studies identified gene expression signatures predictive of metastatic relapse in early breast cancer. Standard feature selection procedures applied to reduce the set genes did not take into account correlation between genes. In this paper, we studied performances three high-dimensional regression methods - CoxBoost, LASSO (Least Absolute Shrinkage and Selection Operator), Elastic net identify prognostic patients with cancer.We analyzed public retrospective datasets, including...
Background and aim More than 50% of the liver should be drained in case unresectable hilar stenosis; however, it remains unclear if use several types drainage (endoscopic retrograde cholangiography pancreatography, percutaneous‐biliary drainage, endoscopic ultrasound biliary (EUS‐BD)), allowing better has an impact on survival. The our study was to evaluate percentage its correlation survival whatever technique used. Patients methods This a retrospective analysis prospective registry...
Acute myeloid leukemia (AML) originates from hematopoietic stem and progenitor cells that acquire somatic mutations, leading to disease clonogenic evolution. AML is characterized by accumulation of immature in the bone marrow phenotypic cellular heterogeneity reflective normal differentiation. Here, we show JAM-C expression defines a subset leukemic endowed with leukemia-initiating cell activity (LIC). Stratification de novo patients at diagnosis based on JAM-C-expressing frequencies blood...
Targeted next-generation sequencing (tNGS) and ex vivo drug sensitivity/resistance profiling (DSRP) have laid foundations defining the functional genomic landscape of acute myeloid leukemia (AML) premises personalized medicine to guide treatment options for patients with aggressive and/or chemorefractory hematological malignancies. Here, we assessed feasibility a tailored strategy (TTS) guided by systematic parallel DSRP tNGS relapsed/refractory AML (number NCT02619071). A TTS issued an...
Background Patients undergoing neoadjuvant chemotherapy before surgery for advanced ovarian cancer may have impaired functional capacity, nutritional status, and emotional well-being. Primary objective(s) TRAINING-01 aims to determine if a connected pre-habilitation program during patients treated an will improve physical capacity major abdomino-pelvic surgery. Study hypothesis A bring fitter patient decrease treatment morbidity oncological outcomes. Trial design This study is prospective,...
Postoperative fluid collection due to pancreatic leak is the most frequent complication after surgery. EUS-guided drainage of post-pancreatic surgery gold standard procedure; however, data on outcomes this procedure are limited. The primary endpoint our study was relapse over longterm followup, and secondary efficiency safety collection.This retrospective conducted at a single center from December 2008 April 2016. Global morbidity defined as occurrence an event involving additional...
Concomitant biliary and duodenal malignant obstruction are a severe condition mainly managed by stenting, which can be performed simultaneously (SAMETIME) or in two distinct procedures (TWO-TIMES). We conducted single-center retrospective study to evaluate the feasibility of SAMETIME procedure impact endoscopic ultrasound (EUS)-hepaticogastrostomy double obstructions.From January 1, 2011, 2018, patients with concomitant bilioduodenal treated endoscopically were included. The primary endpoint...
Background Dysthyroidism (DT) is a common toxicity of immune checkpoint inhibitors (ICIs) and prior work suggests that dysthyroidism might be associated with ICI efficacy. Patients methods ConSoRe, new generation data mining solution, was used in this retrospective study, to extract from electronic patient records adult cancer patients treated at Institut Paoli-Calmettes (Marseille, France). Every DT verified only ICI-induced retained. Survival analyses were performed by Kaplan-Meier method...
Purpose Eribulin is approved for advanced breast cancers refractory to anthracyclines and taxanes. Efficacy according sensitivity previous therapies has been poorly explored. Materials Methods Safety data were collected prospectively we retrospectively efficacy from the five French centres that participated in E7389-G000-398 expanded access program. Our main objectives exploration of safety analysis eribulin (progression-free survival [PFS] overall [OS]) last microtubule-inhibiting agent...
Inflammatory breast cancer (IBC) is a very aggressive form of cancer, as compared to locally advanced (LABC). Neoadjuvant chemotherapy followed by surgery the standard treatment in both cases. Whether IBC less chemosensitive than LABC remains unclear. We retrospectively rate pathological complete response (pCR) neoadjuvant and LABC.Patients with or treated anthracycline-based were selected from our institutional database. The primary endpoint was pCR rate, defined absence invasive tumor...