A5090902015- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Advanced Breast Cancer Therapies
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- Cancer Risks and Factors
- Brain Metastases and Treatment
- Cancer and Skin Lesions
- Photodynamic Therapy Research Studies
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- Pelvic floor disorders treatments
- Colorectal Cancer Surgical Treatments
- Bladder and Urothelial Cancer Treatments
- Angiogenesis and VEGF in Cancer
- Autoimmune and Inflammatory Disorders
- Autism Spectrum Disorder Research
- Skin Diseases and Diabetes
Institut Claudius Regaud
2016-2025
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2024
Institut universitaire du cancer de Toulouse Oncopole
2017-2024
Hôpital de la Conception
2020
Clinique Pasteur
2018
Institut Bergonié
2018
Institut de Cancérologie de l'Ouest
2018
Centre Hospitalier Universitaire de Grenoble
2018
Centre Jean Perrin
2018
Université Toulouse III - Paul Sabatier
2011
Ovarian cancer is the most deadly gynecological cancer. The high rate of mortality due to large tumor burden with extensive metastatic lesion abdominal cavity. Despite initial chemosensitivity and improved surgical procedures, recurrence remains an issue results in patients' poor prognosis. Transcriptomic genetic studies have revealed significant genome pathologies primary tumors yielded important information regarding carcinogenesis. There are, however, few on alterations their consequences...
There is a scarcity of data exploring early breast cancer (eBC) in very young patients. We assessed shared and intrinsic prognostic factors large cohort patients aged ≤35, compared to control group 36 50.Patients ≤50 were retrospectively identified from multicentric 23,134 eBC who underwent primary surgery between 1990 2014. Multivariate Cox analyses for DFS OS built. To assess the independent impact age, 1 3 case-control analysis was performed by matching ≤35 36-50 years patients.Of 6481...
Three randomized trials have concluded at non inferiority of omission complementary axillary lymph node dissection (cALND) for patients with involved sentinel (SN). However, we can outline strong limitations these to validate this attitude a high scientific level. We designed the SERC trial ( ClinicalTrials.gov , number NCT01717131) compare outcomes in SN involvement treated ALND or no further treatment. The aim study was analyze results first 1000 included. is multicenter non-inferiority...
Abstract Background Nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR) is used increasingly when performing a prophylactic mastectomy. Few prospective studies have reported on complication rates. This complementary trial to the French multicentre MAPAM aimed evaluate nipple–areola complex (NAC) necrosis rate in NSM IBR. Methods Patient characteristics and surgical data were recorded. Morbidity after focus NAC was analysed. Results Among 59 women undergoing NSM, 19 (32...
Ovarian cancer is the most deadly gynecological due to late diagnosis at advanced stage with major peritoneal involvement. To date research has focused on primary tumor. However prognosis directly related residual disease end of treatment. Therefore it mandatory focus and study biology metastatic that frequently localized cavity in ovarian cancer.We used high-density gene expression arrays investigate changes between matched (peritoneal) lesions.Here we show profiles metastasis are...
Objectives: To analyze axillary lymph node involvement (ALNI) rate and survival for mucinous (MC) tubular (TC) breast carcinomas considered being of very good prognosis which an surgical exploration could be questioned. Methods: Our multicentric cohort consisted 21,135 patients with clinically node-negative invasive cancer, without neoadjuvant therapy, between 1999 2013 in 10 French centers. ALNI were analyzed according to patient tumor characteristics. Results: 672 TC 245 MC. Patients older...
Local ablative treatment (LAT) is increasingly combined with systemic therapy in oligometastatic breast cancer (OMBC), without a high-level evidence to support this strategy. We evaluated the addition of LAT terms progression-free survival (PFS) and overall (OS). Secondary endpoints were local control (LC) toxicity. sought identify prognostic factors associated longer OS PFS.
The rate of immediate breast reconstruction (IBR) in elderly women (EW) is lower than younger patients because concerns related to postoperative complications (POC) and their consequences. We assessed POC 30 days after IBR, readmissions within days, the time start adjuvant therapy EW aged ≥ 70 years. conducted an observational, retrospective, single-center study between January 2014 May 2022 at University Cancer Institute Toulouse-Oncopole (IUCT-O), including over years old treated with...
Based on results of clinical trials, completion ALND (cALND) is frequently not performed for patients with breast conservation therapy and one or two involved sentinel nodes (SN) by micro- macro-metastases. However, there were limitations despite a conclusion non-inferiority cALND omission. No trial had included SN macro-metastases total mastectomy >2 The aim the study was too analyze treatment delivered pathologic in SERC trial. multicenter randomized phase-3 comparing no cT0-1-2, cN0 ITC...
Abstract Background Results of IBCSG‐23‐01‐trial which included breast cancer patients with involved sentinel nodes (SN) by isolated‐tumor‐cells or micro‐metastases supported the non‐inferiority completion axillary‐lymph‐node‐dissection (cALND) omission. However, current data are considered insufficient to avoid cALND for all SN‐micro‐metastases. Methods To investigate impact omission on disease‐free‐survival (DFS) and overall survival (OS), we analyzed a cohort 1421 <75 years old...
Many trials confirmed the safety of omitting axillary dissection in selected patients treated for early breast cancer. The external validity these is questionable. Our study aimed to evaluate accuracy French population representativity SERC trial and differences between two populations as well comparing Swedish (the SENOMIC National Breast Cancer Registry (NKBC) cohort) with sentinel node (SN) micro-metastasis. A higher rate smaller tumors grade 1 was observed cohort when compared...
Elderly breast cancer (BC) patients have been underrepresented in clinical trials whereas ~60% of deaths from BC occur women aged 70 years and older. Only limited data are available on the prognostic impact age according to treatment, especially triple-negative (TN) Her2-positive because lower frequency these subtypes elderly patients. We report herein results a multicenter retrospective study analyzing treatment delivered TN or older, including comparison by groups. The medical records...
Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim this study was to compare outcome IA-IB PCFT a matched group ovarian cancer (OC).Between 1990 and 2008, 32 patients with were recorded in database three French Institutions. A control OC constituted.Eleven eligible cases 29 controls fulfilled stringent inclusion criteria. Median follow-up 70.2 months. Five-year overall survival 83.3% (95% confidence interval [CI],...
The optimal management of patients with pathologically node-negative triple-negative breast cancer (pN0 TNBC) remains unclear. We hypothesized that lymph node irradiation (LNI; internal mammary chain/periclavicular irradiation) had an impact on outcomes pN0 TNBC. A cohort 126 consecutive TNBC treated between 2007 and 2010 at a single institute were included. All radiotherapy (breast/chest wall, ±LNI) was delivered adjuvantly, following completion surgery ± chemotherapy. Tumors reviewed...