A5025879953- Immune cells in cancer
- Immune Response and Inflammation
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Breast Implant and Reconstruction
- Inflammatory mediators and NSAID effects
- Reconstructive Surgery and Microvascular Techniques
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Multiple and Secondary Primary Cancers
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Male Breast Health Studies
- Cancer Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Advanced Proteomics Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Reconstructive Facial Surgery Techniques
- Cancer and Skin Lesions
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
Institut de Cancérologie de l'Ouest
2012-2022
Roche (France)
2020
Inserm
2019
Clinique Pasteur
2018
Institut Bergonié
2012-2018
Centre Hospitalier Universitaire de Grenoble
2018
Centre Jean Perrin
2012-2018
Centre Léon Bérard
2012
Centre Oscar Lambret
2012
Institut Curie
2012
Abstract In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, angiogenesis. However, the factors conferring inflammatory protumor properties on human remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed impact of monocyte differentiation. report that prolonged lactic acidosis induces differentiation monocytes into with a phenotype including...
Abstract Human olfactomedin‐4 (OLFM4) is a secreted protein involved in variety of cellular functions including proliferation, differentiation, apoptosis, and cell adhesion. OLFM4 expression has been studied several tumor types gastric, colorectal, lung, endometrioid cancers where it suggested to be an independent favorable or unfavorable prognostic marker. For breast cancer, the clinical significance still unclear. In present study, SWATH‐MS used as tool for robust identification...
Three randomized trials have concluded at non inferiority of omission complementary axillary lymph node dissection (cALND) for patients with involved sentinel (SN). However, we can outline strong limitations these to validate this attitude a high scientific level. We designed the SERC trial ( ClinicalTrials.gov , number NCT01717131) compare outcomes in SN involvement treated ALND or no further treatment. The aim study was analyze results first 1000 included. is multicenter non-inferiority...
Based on results of clinical trials, completion ALND (cALND) is frequently not performed for patients with breast conservation therapy and one or two involved sentinel nodes (SN) by micro- macro-metastases. However, there were limitations despite a conclusion non-inferiority cALND omission. No trial had included SN macro-metastases total mastectomy >2 The aim the study was too analyze treatment delivered pathologic in SERC trial. multicenter randomized phase-3 comparing no cT0-1-2, cN0 ITC...
Many trials confirmed the safety of omitting axillary dissection in selected patients treated for early breast cancer. The external validity these is questionable. Our study aimed to evaluate accuracy French population representativity SERC trial and differences between two populations as well comparing Swedish (the SENOMIC National Breast Cancer Registry (NKBC) cohort) with sentinel node (SN) micro-metastasis. A higher rate smaller tumors grade 1 was observed cohort when compared...
Abstract Background: Half of the patient treated with neoadjuvant chemotherapy (NAC) for a large operable breast cancer have no axillary lymph node involvement at time surgery. Sentinel detection (SLND), performed after NAC, would select who might be spared an lymphadenectomy (AL). In previous study, we assessed feasibility SLND NAC in case patients without involvement1. Previous published series shown that, before treatment, bring low rate and high false negative (FNR), making this...
La mastectomie avec conservation de l'étui cutané reconstruction mammaire immédiate (RMI) par grand dorsal, après chimiothérapie (CT) puis radiothérapie externe (RTE) préopératoire, dans les cancers mammaires invasifs.
<div>Abstract<p>In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, angiogenesis. However, the factors conferring inflammatory protumor properties on human remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed impact of monocyte differentiation. report that prolonged lactic acidosis induces differentiation monocytes into with a...
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