A5059122753- Immune cells in cancer
- Immune Response and Inflammation
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pesticide Residue Analysis and Safety
- Sarcoidosis and Beryllium Toxicity Research
- Cancer, Lipids, and Metabolism
- Asymmetric Synthesis and Catalysis
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Cyclopropane Reaction Mechanisms
- S100 Proteins and Annexins
- Melanoma and MAPK Pathways
Université Paris Cité
2020-2024
Inserm
2017-2024
Paris Cardiovascular Research Center
2020-2024
Nantes Université
2017-2023
Université d'Angers
2017-2023
Centre National de la Recherche Scientifique
2022-2023
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022
La Ligue Contre le Cancer
2021
Janssen (Belgium)
2019
Université Nantes Angers Le Mans
2018
Background Resident memory T lymphocytes (T RM ) are located in tissues and play an important role immunosurveillance against tumors. The presence of prior to treatment or their induction is associated the response anti-Programmed cell death protein 1 (PD-1)/Programmed death-ligand (PD-L1) immunotherapy efficacy cancer vaccines. Previous work by our group others has shown that intranasal route vaccination allows more efficient these cells head neck lung mucosa, resulting better tumor...
Abstract In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, angiogenesis. However, the factors conferring inflammatory protumor properties on human remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed impact of monocyte differentiation. report that prolonged lactic acidosis induces differentiation monocytes into with a phenotype including...
There is now a consensus that efficient peptide vaccination against cancer requires peptides should (i) be exclusively presented by professional APC and (ii) stimulate both CD4 CD8-specific T cell responses. To this aim, in recent trials, patients were vaccinated with pools of synthetic long (SLP) (15–30 aa long) composed potential class I epitope(s) elongated at ends native antigen sequences to also provide II epitope(s). Using MELOE-1 as model antigen, we present an alternative strategy...
Abstract Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are able differentiate from monocytes under such acidotic conditions, remain active in order resolve underlying injury. Here we show that, lactic human differentiating into macrophages characterized depolarized mitochondria, transient reduction mitochondrial mass due mitophagy, significant decrease nutrient...
Rationale: Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins promotes their removal. Objectives: We investigated whether CLU could protect against properties of histones. Methods: assessed histone expression patients with sepsis evaluated protective role histones vitro assays...
<h3>Background</h3> Immune checkpoint inhibitors (ICI) target T cell inhibitory pathways that are responsible for cancer tolerance by down-modulating immune functions. ICI have revolutionized patients care with lung cancer. Nevertheless, restoring endogenous antitumor T-cell responses can induce related adverse events, such as sarcoidosis. <h3>Case presentation</h3> We report here the first case of a thoracic and cutaneous sarcoid-like reaction in patient relapsing unresectable non-small...
A high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed using a chiral column based on amylose tris(3-chloro-5-methylphenylcarbamate) for analysis of fipronil (a popular insecticidal nerve agent) and the related transformation products. The optimized reached goal simultaneous complete separation multiple fiproles in single run, including enantiomers, metabolites, photoproducts. efficacy such demonstrated by its application analyzing series samples exposed to...
Background A high density of resident memory T cells (T RM ) in tumors correlates with improved clinical outcomes immunotherapy-treated patients. In most studies, are defined by the CD103 marker. However, it is clearly established that not all express CD103, but can be other markers (CD49a, CD69, etc). The frequency these subpopulations expressing or varies according to location cancer. Little known about their functionality and predictive impact on response immunotherapy. preclinical...
Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity inflammation. However, the role of pro-atherogenic environment its associated low-grade inflammation in tumor progression remains underexplored. Here we show that feeding C57BL/6J mice with a non-obesogenic high fat cholesterol diet (HFHCD) for two weeks to induce mild increases pool circulating Ly6Chi monocytes available initial melanoma development, an IL-1β-dependent manner. Descendants myeloid...
Abstract A high density of resident memory T cells (T RM ) in tumors correlates with improved clinical outcomes immunotherapy-treated patients. However, preclinical models, only some subpopulations are associated cancer vaccine efficacy. We identified two main tumor-infiltrating lymphocytes derived from non-small cell lung (NSCLC) patients: one co-expressing CD103 and CD49a (DP), the other expressing (MP); both exhibiting additional surface markers like CD69. DP exhibited greater...
Herein we report the preparation of 2'-deoxy-2'-spirocyclopropylcytidine via an alternative cyclopropanation reaction starting from γ-silyl tertiary alcohols. Activation hydroxyl function with thionyl chloride in presence 4-DMAP allows ring-closing step under mild conditions. Participation uracil moiety cyclization is proposed.
<div>Abstract<p>In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, angiogenesis. However, the factors conferring inflammatory protumor properties on human remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed impact of monocyte differentiation. report that prolonged lactic acidosis induces differentiation monocytes into with a...
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