A5043521544- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Amino Acid Enzymes and Metabolism
- Hormonal Regulation and Hypertension
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Chemokine receptors and signaling
- Cancer, Stress, Anesthesia, and Immune Response
Institute for Research and Innovation in Biomedicine
2019-2021
Inserm
2019-2021
Université de Rouen Normandie
2019-2021
Normandie Université
2021
There is now a consensus that efficient peptide vaccination against cancer requires peptides should (i) be exclusively presented by professional APC and (ii) stimulate both CD4 CD8-specific T cell responses. To this aim, in recent trials, patients were vaccinated with pools of synthetic long (SLP) (15–30 aa long) composed potential class I epitope(s) elongated at ends native antigen sequences to also provide II epitope(s). Using MELOE-1 as model antigen, we present an alternative strategy...
Adoptive immunotherapy based on the transfer of anti-tumor cytotoxic T lymphocytes (CTLs) is a promising strategy to cure cancers. However, rapid expansion numerous highly functional CTLs with long-lived features remains challenge. Here, we constructed NIH/3T3 mouse fibroblast-based artificial antigen presenting cells (AAPCs) and precisely evaluated their ability circumvent this difficulty. These AAPCs stably express essential molecules involved in CTL activation HLA-A*0201 context an...