A5017618036- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- CAR-T cell therapy research
- Oral and Maxillofacial Pathology
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Tumors and Oncological Cases
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
Hôpital Européen Georges-Pompidou
2016-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Institut Gustave Roussy
2013-2025
Hôpital Européen
2015-2024
Centre Henri Becquerel
2024
Université de Rouen Normandie
2024
Paris Cardiovascular Research Center
2014-2023
Sorbonne Université
2008-2022
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In study, we focused on comparison regulatory Foxp3(+) T programmed death-1 (PD-1)(+) microenvironment tumors were negative HPV, two groups matched various biologic parameters. HPV-positive head...
Abstract Purpose: CD4+ T cells play a central role in initiating and maintaining anticancer immune responses. However, regulatory CD4+CD25+ which express Foxp3 have also been shown to inhibit antitumor effector cells. In view of these heterogeneous T-cell populations, this study was designed determine the prognostic value various tumor-infiltrating populations head neck squamous cell carcinoma. Experimental Design: Eighty-four newly diagnosed untreated patients with histologically proven...
Abstract The immune defect that could account for the multisystemic involvement characterizes systemic lupus erythematosus (SLE) remains unknown. We hypothesized iterative disease flares correspond to a recurrent in peripheral suppression exerted by naturally occurring T regulatory cells (Tregs). Surprisingly, Tregs isolated from patients show same phenotypic and functional characteristics as corresponding found healthy controls. A decrease proportion of circulating among other CD4+ is...
Sarcoidosis is characterized by extensive local inflammation (granuloma, cytokine secretion) associated with anergy (poor response to antigens in vitro and vivo). We postulated that this paradoxical situation would correspond a disequilibrium between effector regulatory T lymphocytes (T reg cells). show CD4+CD25brightFoxP3+ cells accumulate at the periphery of sarcoid granulomas, bronchoalveolar lavage fluid, peripheral blood patients active disease. These exhibited powerful...
Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and drug resistance, but its impact on immune surveillance has not been explored. In this study, we investigated the functional consequences of mode epithelial plasticity targeted lysis by cytotoxic T lymphocytes (CTL). Acquisition EMT phenotype in various derivatives MCF-7 human breast cells was associated with dramatic morphologic changes actin cytoskeleton remodeling, CD24(-)/CD44(+)/ALDH(+) stem...
Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), SDHAF2, required for flavination SDHA. A recent report described a patient with an abdominal paraganglioma, immunohistochemically negative SDHA, identified causal germline mutation SDHA.In this study, we evaluated the significance SDHA immunohistochemistry identification new patients mutations.This study was performed Erasmus Medical Center Rotterdam...
Abstract Tissue-resident memory T cells (Trm) represent a new subset of long-lived that remain in tissue and do not recirculate. Although they are considered as early immune effectors infectious diseases, their role cancer immunosurveillance remains unknown. In preclinical model head neck cancer, we show intranasal vaccination with mucosal vector, the B subunit Shiga toxin, induces local Trm inhibits tumour growth. As recirculate, demonstrate crucial efficacy vaccine parabiosis experiments....
Mucosal vaccination induces targeted CD8 + T cell homing to inhibit mucosal tumors.
Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8+ coexpressing inhibitory PD-1 and Tim-3 from patients renal cell carcinoma (RCC). A second validation cohort measured same parameters cytometry. The percentage tumor-infiltrating correlated an aggressive phenotype a larger size at diagnosis....
The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia effect, we studied mitochondrial electron transport, angiogenesis in pheochromocytomas induced by germ-line mutations VHL, RET, NF1 SDH genes. VHL gene have been shown lead activation of hypoxic response, even normoxic conditions, a process now referred as pseudohypoxia. We observed decrease transport protein...
Sunitinib, an antiangiogenic molecule, is one of the first-line standard care in treatment patients with metastatic renal cell carcinoma. However, it only benefits to a subgroup and no predictive markers sunitinib efficacy have been identified. Twenty-eight carcinomas were treated sunitinib-based therapy another 7 primary cancer also by neoadjuvant trial. Measurements CD3+CD4+CD25hi Foxp3+ regulatory T cells, immunosuppressive population, performed before after each cycle blood tumor...
Abstract Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated genomic examination of large collection PCC/PGL. SNP array analysis reveals distinct copy-number patterns associated background. Whole-exome sequencing shows low mutation rate 0.3 mutations per megabase, few recurrent somatic in genes not previously DNA methylation arrays miRNA identify changes expression clusters strongly...
Immunological effects of donor lymphocyte infusion for treatment recurrent malignancy after allogeneic hematopoietic cell transplantation can be enhanced by depleting T regulatory cells in the infused and recipient.
Intraductal carcinoma (IC) is the new World Health Organization designation for tumors previously called "low-grade cribriform cystadenocarcinoma" and salivary duct carcinoma." The relationship of IC to controversial, but they now are considered be distinct entities. a rare low-grade malignant gland neoplasm with features similar mammary atypical ductal hyperplasia or in situ, that shows diffuse S100 protein mammaglobin positivity only partially defined genetically. (Mammary analogue)...
Angiogenesis is a key feature of liver fibrosis. Although sinusoidal remodeling believed to contribute fibrogenesis, the impact angiogenesis on resolution fibrosis remains undefined. Myeloid cells, particularly macrophages, constantly infiltrate fibrotic and can profoundly sinusoids. We observe that development associated with decreased hepatic vascular endothelial growth factor (VEGF) expression as well rarefication scar. In contrast, characterized by rise in VEGF levels revascularization...
Development of precision medicine for malignant pleural mesothelioma (MPM) requires a deep knowledge tumor heterogeneity. Histologic and molecular classifications histo-molecular gradients have been proposed to describe heterogeneity, but deeper understanding gene mutations in the context MPM heterogeneity is required associations between clinical data need be refined. We characterized genetic alterations on one largest series (266 samples), well annotated with histologic, patients. Targeted...