A5077964736- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Pancreatic and Hepatic Oncology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Folate and B Vitamins Research
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Iron Metabolism and Disorders
- Occupational exposure and asthma
- Occupational and environmental lung diseases
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Dermatological and Skeletal Disorders
- Transgenic Plants and Applications
- S100 Proteins and Annexins
- Clusterin in disease pathology
- Skin and Cellular Biology Research
- Cerebrovascular and genetic disorders
- Chronic Kidney Disease and Diabetes
- Dermatological and COVID-19 studies
- Genital Health and Disease
- Erythropoietin and Anemia Treatment
Université d'Angers
2019-2024
Inserm
2015-2024
Nantes Université
2019-2024
Centre National de la Recherche Scientifique
2022-2024
Centre Hospitalier Universitaire d'Angers
2019-2024
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2022-2024
Délégation Paris 5
2015-2021
Hôpital Européen Georges-Pompidou
2015-2021
Université Paris Cité
2015-2021
Hôpital Européen
2016-2021
Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8+ coexpressing inhibitory PD-1 and Tim-3 from patients renal cell carcinoma (RCC). A second validation cohort measured same parameters cytometry. The percentage tumor-infiltrating correlated an aggressive phenotype a larger size at diagnosis....
Rationale: Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins promotes their removal. Objectives: We investigated whether CLU could protect against properties of histones. Methods: assessed histone expression patients with sepsis evaluated protective role histones vitro assays...
Antineutrophil-cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage disease (ESKD) despite aggressive immunosuppressive treatment. Several risk scores have been used assess renal prognosis. We aimed determine whether function and markers of AAV-GN activity after 6 months could improve the prediction ESKD.This retrospective observational study included adult patients recruited from six French nephrology centers (including...
Several scores have been developed to predict mortality at anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) diagnosis. Their prognostic value in Caucasian patients with kidney involvement (AAV-GN) remains uncertain as none has this specific population. We aimed propose a novel and more accurate score for them.
Background: Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective clinical study analyze the impact crystalline (CS) on T cell phenotype and regulatory cells (Tregs) frequency, as well auto-antibodies development non-silicotic workers exposed CS. Methods: Workers...
Cyclin B1 (CCNB1) is considered as a potential target for cancer vaccine, it overexpressed in many malignant cells, while being transiently expressed normal cells. To evaluate the CD4 T cell response to CCNB1, we derived lines by multiple weekly rounds of stimulation with recombinant CCNB1 cells collected healthy donors (long-term assays). were specific 15 immunodominant peptides and preferentially from naive From 74 overlapping peptides, 20 selected their broad specificity binding HLA class...
Immune cells are important components of the tumor microenvironment and influence growth evolution at all stages carcinogenesis. Notably, it is now well established that immune infiltrate in human tumors can correlate with prognosis response to therapy. The analysis has become a major challenge for classification patients treatment. co-expression inhibitory receptors such as Program Cell Death Protein 1 (PD1; also known CD279), Cytotoxic T Lymphocyte Associated 4 (CTLA-4), T-Cell...
ABSTRACT Background Anti-neutrophil cytoplasmic antibody (ANCA) kinetic in ANCA-associated vasculitis with glomerulonephritis (AAV-GN) has been suggested to be associated AAV relapse. Few studies have focused on its association renal prognosis. Thus we aimed investigate the relationship between ANCA specificity and evolutive profile outcomes. Methods This multicentric retrospective study included patients diagnosed ANCA-GN since 1 January 2000. Patients without at diagnosis fewer than three...
Abstract Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system resulting from reactivation John Cunningham virus (JCV). PML occurs almost exclusively during profound immune suppression but it can also be observed in immunocompromised subjects as part an inflammatory reconstitution syndrome (IRIS) patients receiving antiviral therapy. We report case 61‐year‐old patient with acute myeloid leukemia who had developed after discontinuation...
Electrophoresis-derived techniques for anti-SSA/Ro60 KDa (anti-SSA) antibodies detection have been progressively replaced by methods using non-native antigens. We aimed to compare the patients’ phenotypes and occurrence of extraglandular manifestations in primary Sjögren’s syndrome according method used detect anti-SSA antibodies. Sera from patients with a diagnosis pSS ACR/EULAR 2016 criteria between 2008 2017 were tested antigens (magnetic bead multiplex assay; line immunoassays) one...
Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by ectopic calcification of tissues rich in elastic fibres (OMIM 264800). To date, PXE considered metabolic disease linked to an imbalance between pro- and anti-calcifying factors. The occurrence sporadic erythematous flareups skin lesions complaint that we heard about on several occasions at the French reference centre. However, this rare clinical aspect had never been extensively studied. We have opportunity investigate...
We retrospectively analyzed the medical records of patients presenting with vitamin B 12 deficiency and IFA / or PCA followed between January 2015 December 2018 in Department Internal Medicine Angers University Hospital.Patients supplementation doses other than 1000 µg daily oral cyanocobalamin were excluded.Vitamin was defined as plasma levels 200 ng/l lower, 201 350 an elevation homocysteine (≥13 µmol/l women, ≥15 men, absence folate renal failure creatinine clearance <30 ml/min/1.73m 2 )....
<div>Abstract<p>Inhibitory receptors expressed by T cells mediate tolerance to tumor antigens, with coexpression of these exacerbating this dysfunctional state. Using the VectraR automated multiparametric immunofluorescence technique, we quantified intratumoral CD8<sup>+</sup> coexpressing inhibitory PD-1 and Tim-3 from patients renal cell carcinoma (RCC). A second validation cohort measured same parameters cytometry. The percentage tumor-infiltrating correlated an...
<p>Figure S1 : Heterogeneous distribution of various subpopulations intratumor CD8+T cells defined by the differential expression PD1 and Tim-3 using an in situ multiparametric immunofluorescence technique. Figure S2: PD-1 co-expression on (in IF analyzis) correlates with clinical parameters RCC aggressiveness S3 Relationships between total number T Progression Free Survival S4: tumor-infiltrating analyzed cytometry S5: Patients who co-expressed more often exhibited clear cell...
<p>Figure S1 : Heterogeneous distribution of various subpopulations intratumor CD8+T cells defined by the differential expression PD1 and Tim-3 using an in situ multiparametric immunofluorescence technique. Figure S2: PD-1 co-expression on (in IF analyzis) correlates with clinical parameters RCC aggressiveness S3 Relationships between total number T Progression Free Survival S4: tumor-infiltrating analyzed cytometry S5: Patients who co-expressed more often exhibited clear cell...