A5019405977- Adrenal and Paraganglionic Tumors
- Organ Transplantation Techniques and Outcomes
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Endometriosis Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Uterine Myomas and Treatments
- Glioma Diagnosis and Treatment
- Hernia repair and management
- Liver Disease Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Transplantation Outcomes and Treatments
- Appendicitis Diagnosis and Management
- Pancreatitis Pathology and Treatment
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris Cité
2015-2024
Hôpital Cochin
2015-2024
Délégation Paris 5
2012-2023
Centre National de la Recherche Scientifique
2011-2023
Bispebjerg Hospital
2023
Sorbonne Paris Cité
2011-2022
Inserm
2010-2022
Institut Cochin
2009-2022
University of Göttingen
2022
Background —In congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has been suggested that spironolactone may decrease fibrosis. We investigated the interactions between serum markers fibrosis and effect on outcome in patients with CHF. Methods Results —A sample 261 from Randomized Aldactone Evaluation Study (RALES) were randomized to placebo or (12.5 50 mg daily). Serum procollagen type I carboxy-terminal peptide, amino-terminal III...
BACKGROUND: Deeply infiltrating endometriosis (DIE) is recognized as a specific entity responsible for pain. The distribution of locations and their contribution to surgical management has not been previously studied. METHODS: Medical, operative pathological reports 241 consecutive patients with histologically proven DIE were analysed. lesions classified as: (i) bladder, defined infiltration the muscularis propria; (ii) uterosacral ligaments (USL), USL alone; (iii) vagina, anterior...
Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography.P Legmann, O Vignaux, B Dousset, A J Baraza, L Palazzo, I Dumontier, Coste, Louvel, G Roseau, D Couturier BonninAudio Available | Share
BACKGROUND: To investigate whether knowledge of the anatomical distribution histologically proven deeply infiltrating endometriosis (DIE) lesions contributes to understanding pathogenesis. METHODS: Observational study between June 1992 and December 2004 (retrospective 2000; prospective 2001 2004). Continuous series 426 patients suffering from pelvic pain who underwent complete surgical exeresis DIE. DIE were classified according four different possibilities: (i) Firstly, as located in...
Adrenocortical carcinomas (ACC) are rare tumors with a poor prognosis. Few reports concerning large and homogeneous series available.We aimed to determine the clinical characteristics outcome of ACC identify prognostic factors.This study is descriptive multivariate analysis cohort from single endocrinology center.A total 202 consecutive patients were studied.The sex ratio (female male) was 2.7. Mean age at diagnosis 44 +/- 16 yr (range, 11-88 yr). We found that 154 (76%) had hypersecreting...
Background: Heat waves have a drastic impact on urban populations, which could increase with climate change.Objectives: We evaluated new indicators of elderly people’s exposure to heat in Paris, from public health prevention perspective, using satellite thermal images.Methods: used time series 61 images the satellites National Oceanic and Atmospheric Administration’s (NOAA) Advanced Very High Resolution Radiometer (AVHRR) taken 1 13 August 2003 produce minimum, maximum, mean surface...
Purpose Adrenocortical tumors, especially cancers, remain challenging both for their diagnosis and prognosis assessment. The aim of this article is to identify molecular predictors malignancy survival. Patients Methods One hundred fifty-three unilateral adrenocortical tumors were studied by microarray (n = 92) or reverse transcription quantitative polymerase chain reaction 148). A two-gene predictor was built using the disease-free survival as end point in a training cohort 47), then...
<h3>Objective</h3> Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are most commonly used treatments. However, prospective data comparing their long-term efficacy lacking. <h3>Design</h3> 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM (n=105). Before randomisation, symptoms assessed using Eckardt score, functional test performed quality life was assessed. The...
To assess with a single-blinded, multicenter, randomized trial, the postoperative results in patients undergoing sphincter-saving rectal resection for cancer without preoperative mechanical bowel preparation (MBP).The collective evidence from literature strongly suggests that MBP, before elective colonic surgery, is of no benefit terms morbidity. Very few data and study are available surgery preliminary conclude toward safety MBP.From October 2007 to January 2009, scheduled were receive MBP...
Treatment of locally advanced rectal cancer involves chemoradiation, followed by total mesorectum excision. Complete response after chemoradiation is an accurate surrogate for long-term local control. Predicting complete from pre-treatment features could represent a major step towards conservative treatment. Patients with T2-4 N0-1 adenocarcinoma treated between June 2010 and October 2016 neo-adjuvant three academic institutions were included. All clinical treatment data was integrated in...
Abstract Background Radical surgery provides the best chance of cure for adrenocortical carcinoma (ACC), but perioperative surgical care these patients is yet to be standardized. Methods A working group appointed jointly by ENSAT and ESES used Delphi methodology produce evidence-based recommendations with ACC. Papers were retrieved from electronic databases. Evidence classified according Grading Recommendations, Assessment, Development Evaluation (GRADE) system, discussed until consensus was...
CT, Endoscopic Sonography, and a Combined Protocol for Preoperative Evaluation of Pancreatic InsulinomasHervé Gouya1, Olivier Vignaux1, Joelle Augui1, Bertrand Dousset2, Laurent Palazzo3, André Louvel4, Stanislas Chaussade3 Paul Legmann1Audio Available | Share
Transvaginal ultrasonography (TVUS) has important advantages compared with transrectal (TRUS): it is less invasive, cost-effective, a familiar and well-accepted approach, anesthesia not required. We the accuracy of TVUS TRUS for diagnosing rectal wall involvement in patients presenting histologically proved deeply infiltrating endometriosis (DIE).Prospective study 134 DIE underwent preoperative investigations using both TRUS. The radiologist sonographer (TRUS) were unaware clinical findings...
Adrenalectomy is a radical treatment for hypercortisolism in Cushing's disease. However, it may lead to Nelson's syndrome, originally defined by the association of pituitary macroadenoma and high plasma ACTH concentrations, much feared complication.The objective study was reconsider syndrome investigating corticotroph tumor progression based on magnetic resonance imaging scan search predictive factors.This retrospective cohort study.The complete medical records disease patients at Cochin...
Abstract Summer warming trends in Western Europe are increasing the incidence, intensity and duration of heat waves. They especially deadly large cities owing to population density, physical surface properties, anthropogenic pollutants. In August 2003, for 9 consecutive days, Paris metropolitan area experienced an extreme wave that caused 4867 estimated heat‐related deaths. A set 61 NOAA‐AVHRR (advanced very high‐resolution radiometer) images one SPOT‐high resolution visible (HRV) image were...
The aim of this study was to review our experience in orthotopic liver transplantation (OLT) for biliary atresia (BA) children and analyze the survival prognostic factors, long-term outcome. We reviewed 332 OLTs performed 280 between years 1986 2000. Univariate multivariate analysis were on patient graft survivals according recipients' donors' characteristics as well intraoperative data. outcome among 80 living at 10 after OLT studied growth, immunosuppressive therapy, renal functions. Liver...
We conducted a prospective study to assess the long-term results of complete surgery for low rectal endometriosis (LRE), paying particular attention surgical complications, functional results, and disease recurrence after follow-up at least 5 years.Deep infiltrating (DIE) may infiltrate midlow rectum lead severe pelvic pain. Complete resection LRE is reluctantly considered by young women childbearing age.From 1995 2003, 100 with pain previous incomplete (n=82) underwent open thorough...